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Companion Diagnostics in Personalized Medicine and Cancer Therapy
Date:8/6/2014

ucture 45
3.6 The Case for Theranostics 46
3.7 Companion Diagnostics Market Analysis 47

4. Biomarker Tests Co-developed with Cancer Therapeutics as Companion Diagnostics 49
4.1 Sector Overview 49
4.1.1 Impact of New Technology Platforms 49
4.1.2 Impact on Drug Discovery 49
4.1.3 Biomarkers as Endpoints in Drug Discovery 50
4.1.4 Targeted Therapy 51
4.2 Companion Diagnostics on the Market 51
4.3 Epidermal Growth Factor Receptor Companions 53
4.3.1 Bevacizamab (Avastin) 54
4.3.2 EGFR for CRC and Camptosar (Irinotecan) 55
4.3.2.1 Companion Diagnostic Test Developed for UGT1A1 for Irinotecan 55
4.3.2.2 Companion Diagnostic Test Developed for Bristol-Myers' SPRYCEL 55
4.3.3 EGFR Express and Erbitux (Cetuximab) 55
4.3.4 HER2 and Herceptin (Trastuzumab) 56
4.3.4.1 Bayer's Advia Centaur HER2/neu Assay 58
4.3.4.2 Companies Marketing HER2/neu Assays 58
4.3.5 Iressa and Tarceva Companion Test 58
4.3.6 Tykerb (GlaxoSmithKline (GSK)) and Vectibix (Amgen) Companion Tests 58
4.3.7 EGFRx Assay 59
4.3.8 Monogram eTag 59
4.3.9 Veripath OncoDiagnostics EGFR PharmDX 60
4.3.10 NSCLC Patients with EGFR Mutation 60
4.3.11 A Personalized Medicine Program for CML 60
4.4 Companions Based on Myriad's IVDMIA Technology 61
4.4.1 Myriad's TheraGuide 5-FU 61
4.4.2 Myriad's BRACAnalysis: Hereditary Cancer Testing for Hereditary Breast and Ovarian Cancer 61

4.5 Companions for Tyrosine Kinase Inhibitors: Erlotinib and Gefitinib 62
4.5.1 TheraScreen: EGFR29 62
4.5.2 The K-RAS Mutation Detection Kit 62
4.6 Irinotecan and UGT1A1 62
4.7 Gleevec (Imatinib) Companions 63
4.7.1 DakoCytomation's c-Kit (9.7) pharmDx 63
4.8 Companion Diagnostics Involving Metabolizing Enzymes 64
4.8.1 Companions for TMPT, CYP2C9 and UGT1A1 Enzymes 64
4.8.2 Companions for Aromatase Inhibitors 64
4.8.3 Companions for Actos and Avandia 65
4.9 Drivers and Barriers to Com
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