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Commonly Prescribed Osteoporosis Drug Associated with Very Low Risk of Serious Jaw Disease
Date:2/14/2011

e drugs," added Pihlstrom.

The authors caution that their confidence in the association between oral bisphosphonates and osteonecrosis of the jaw is limited because they found so few cases. The small number of cases also limited their ability to control for other risk factors.  Also, since osteonecrosis of the jaw did not have a diagnosis code before 2007, the authors used a computer program to search medical records for any diagnosis, procedure, or physician chart note that could indicate a possible case. Manual chart review was used to confirm osteonecrosis of the jaw among patients identified by the computer. Some additional cases were found through conversations with general dentists and oral surgeons serving patients from each health care organization. While the search was extensive, there is a chance that some cases were missed.

The study was supported by grants DE-16746 and DE-16747 from the National Institutes of Health. Authors of the paper include Jeffrey L. Fellows, PhD, and Christine M. Gullion, PhD, from the Kaiser Permanente Center for Health Research in Portland, Ore.;  Daniel J. Pihlstrom, DDS, with Permanente Dental Associates in Portland; D. Brad Rindal, DDS, and William Rush, PhD, with HealthPartners Research Foundation in Minneapolis; Andrei Barasch, DMD, MDSc., with the Department of General Dental Sciences, University of Alabama at Birmingham; and Joshua Richman, MD, PhD, with the Division of Preventive Medicine, University of Alabama at Birmingham.

About the Kaiser Permanente Center for Health Research

http://www.kpchr.org

Kaiser Permanente's Center for Health Research, founded in 1964, is a nonprofit research institution dedicated to advancing knowledge to improve health. It has research sites in Portland, Ore., Honolulu and Atlanta.

About Kaiser Permanente

Kaiser Permanente is committed to helping sha
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