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Commencement of a Phase II Clinical Trial of SG2000 in Ovarian Cancer
Date:9/15/2010

apeutic alternative for oncologists, not only in treating ovarian cancer patients but also in the other indications in which we are currently initiating clinical trials."

Celtic Therapeutics provided funding in support of the Phase II clinical trial, and has an option to acquire and develop SG2000.  Celtic Therapeutics and Spirogen are also initiating a clinical trial for SG2000 in leukemia, which they anticipate will commence by year end.    

About Resistant Ovarian Cancer

Ovarian cancer is the sixth most commonly diagnosed cancer in women and the eighth leading cause of cancer death among women worldwide, according to the American Cancer Society. Annually, an estimated 230,000 women are diagnosed with ovarian cancer around the world and around 140,000 die from the disease. Although treatable when detected early, most diagnoses occur at advanced stages, and at that stage 5-year survival rates are 69% for patients with regionally advanced disease and 30% for patients with distant metastases.

ABOUT SG2000

SG2000 (SJG-136/BN2629/NSC 694501) is a small molecule which spans six base pairs of DNA in the minor groove, inducing DNA cross links, and is currently undergoing clinical development in refractory solid tumors and hematological malignancies under a CRADA (Cooperative Research And Development Agreement) with the Division of Cancer Treatment and Diagnosis as supported by NIH U01 CA099177 and M01 RR00095 grants. The agent belongs to an entirely new class of DNA minor groove binding agents designed to minimize detection of the induced DNA lesions by the DNA repair machinery and encouraging clinical results have been reported in refractory solid tumors cancer at recent ASCO meetings.

ABOUT SPIROGEN LIMITED

Spirogen is a privately owned UK company, founded in 2001 by Professor David Thurston and Dr. Phillip Howard (now at the School of Pharmacy, University of London), Professor John H
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SOURCE Celtic Therapeutics
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