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Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica
Date:4/3/2008

uamous cell carcinoma of the lung with specificity of 90 percent and sensitivity of 96 percent. This is the first test utilizing microRNAs' unique sensitivity and specificity as biomarkers that may offer a standardized and objective method for cancer classification.

The genetic classification can be especially important for selecting proper treatment as therapies have been shown to act differently depending on cancer type, such as the case between squamous (scalelike) and non-squamous non-small cell lung cancer (NSCLC). Approximately 185,000 people are diagnosed with either squamous or non-squamous NSCLC each year in the United States.

"The importance of accurately differentiating squamous cell from non-squamous NSCLC has recently been an issue of great interest and is gaining importance as new targeted therapies for NSCLC enter the market or proceed to late stages of development," said Dr. Dalia Cohen, chief scientific officer of Rosetta Genomics. "This is a great advancement in terms of physicians' ability to better treat patients with targeted therapies, which are currently highly effective in some patients while being less effective and sometimes harmful for others."

"We are excited to have performed the validation of the first diagnostic test based on microRNAs, and believe this endeavor is an important next step in bringing better diagnostics to patients and physicians," noted Dr. Mahesh Mansukhani, director of the Molecular Pathology Laboratory at Columbia University Medical Center, who has led the validation process and submission of the test to the New York State Department of Health for approval. "Using a single microRNA biomarker, the test demonstrates high sensitivity and specificity, for squamous differentiation. Once approved, we will be pleased to offer this test through our pathology laboratory nationwide to doctors and patients as an objective aid in the classification of NSCLC. "

Data presented in peer reviewed publicati
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SOURCE Rosetta Genomics Ltd
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