Navigation Links
Collaborative Preclinical Efficacy Studies Suggest a New Target for Drug Addiction Treatment
Date:3/14/2012

MENLO PARK, Calif., March 14, 2012 /PRNewswire/ -- In preclinical studies, researchers at SRI International and Astraea Therapeutics have recently evaluated the role of a new drug receptor target that shows promise for the treatment of drug addiction.

This potential new drug target belongs to a class of receptors called the nicotinic acetylcholine receptors (nAChRs). One subtype of nAChRs, called alpha4beta2, is a well-known target for nicotine's addictive effects and the therapeutic effect of the smoking cessation drug varenicline.  SRI researchers are now studying another, lesser-known subtype, called alpha3beta4 nAChR, which has recently shown to play a role in the addictive properties of cocaine, morphine, and nicotine.

Using AT-1001, a highly selective alpha3beta4 compound developed by Astraea Therapeutics, SRI researchers found that addiction processes could be disrupted. In preliminary studies, AT-1001 also reduced nicotine withdrawal symptoms such as anxiety. 

Because addictive drugs act on the brain's "reward circuit," many people compulsively take them despite their harmful consequences.  Feelings of pleasure are caused by the release of brain chemicals, or neurotransmitters, and their increased activity in the brain reward circuit.  The key neurotransmitter in the reward circuit is dopamine, which produces changes in addictive behavior.  Researchers speculate that disruption of the alpha3beta4 nAChR system using highly selective drugs such as AT-1001 may interrupt this reward circuitry.

"Currently, there are no therapeutics approved to treat addiction to stimulants such as cocaine, so it is intriguing to find a promising drug receptor target and to see that AT-1001 can indeed affect phenomena that are thought to be deeply tied to the addictive nature of cocaine and other drugs of abuse," said Taline Khroyan, Ph.D., Senior Behavioral Pharmacologist in SRI's Center for Health Sciences.


'/>"/>

SOURCE SRI International
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. CellCyte Genetics Corp. Enters Collaborative Research Agreement With Cleveland Clinic Foundation to Qualify Stem Cell Delivery in Damaged Heart Tissue
2. UM Maryland Industrial Partnerships Program Approves 18 Collaborative Research Projects, Worth $4.4 Million, Between University Faculty, State Technology Companies
3. Rib-X Pharmaceuticals Renews Collaborative Agreement with the Medical Research Council
4. The Leukemia & Lymphoma Society and Anjin Group Announce Multi-Year Collaborative Research Agreement
5. ACORN Presents Findings of Collaborative Metastatic Colorectal Cancer Research
6. BASF Officially Launches the Collaborative Advanced Research Initiative at Harvard University
7. CellCyte Genetics Signs Collaborative Agreement With Northwestern Universitys Feinberg School of Medicine to Perform Disease Model Outcome Study of CellCytes CCG-TH30 Product Candidate
8. Two Hutchinson Center Scientists Receive a Total of $16.7 Million for Collaborative Stem Cell Research
9. iThemba Pharmaceuticals (Pty) Ltd and Pyxis Discovery B.V. Announce Collaborative Agreement to Offer a Combined Service Offering
10. Rib-X Pharmaceuticals Enters into Collaborative Agreement on Delafloxacin with Massachusetts General Hospital
11. Medco, State of Illinois and Community Retail Pharmacies Launch Wired Collaborative Solution to Close Critical Medication-Related Gaps in Healthcare, Improving Outcomes and Lowering Costs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... -- "Australia Capsule Endoscopy Systems Market Outlook to 2020″, ... Systems market. The report provides value, in millions of ... US dollars) within market segments: Photo - ... , Capsule Endoscopy Data Recorders , Capsule ... company shares and distribution shares data for each of ...
(Date:7/25/2014)... NEW YORK , July 25, 2014  Smile ... selected to showcase their Virtual Surgery Simulator among ... 2014, which will take place in Washington, ... for the Performing Arts. "Smile Train ... BioDigital alongside the talented community of innovators in health ...
(Date:7/25/2014)... /PRNewswire-iReach/ -- Full Service CRO WCCT Global ... President of Business Development. Peter has been in the ... of different business development positions with some of the ... related to business development/sales management and marketing.  The experience ... him a key and strategic asset to WCCT Global ...
Breaking Medicine Technology:Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 2Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 3Contract Research Organization WCCT Global Welcomes Peter Nieto as Vice President of Business Development 2
... 5, 2011 Spring Bank Pharmaceuticals today announced ... National Institute of Health, National Institute of Allergy and Infectious ... orally bioavailable agent for the treatment of Hepatitis B virus ... Spring Bank Pharmaceuticals will receive $3.9 million over five years ...
... As interventional cardiologists increasingly perform ... (wrist) access versus femoral (groin or upper leg) ... and competency guidelines, according to the first report ... (SCAI) Transradial Working Group released today at the ...
Cached Medicine Technology:Spring Bank Pharmaceuticals Awarded $3.9 Million RO1 NIH Grant to Advance Innovative Hepatitis Program 2SCAI Releases First Report on Transradial Access for Angioplasty and Stenting 2SCAI Releases First Report on Transradial Access for Angioplasty and Stenting 3
(Date:7/25/2014)... Midland, TX (PRWEB) July 25, 2014 ... for accidents or unexpected collisions can pay higher premiums ... has enhanced its local insurer network to provide SR22 ... http://quotespros.com/auto-insurance.html . , The different coverage network of ... policies has expanded the search platform now publicly available ...
(Date:7/25/2014)... 25, 2014 Ticket Down ... board for the Guinness International Champions Cup match between ... at Soldier Field on Sunday, July 27th. ... appreciation promo/coupon/offer code SOCCER-2014 for added savings. , 2014 ... diehard soccer fans in North America. Countless international soccer ...
(Date:7/25/2014)... City, UT (PRWEB) July 25, 2014 ... court surfaces for the recent Nike National Invitational ... the current United States Junior National Tournament (USJN) ... July 25. , The flooring for these prestigious national ... more than 300,000 square feet of playing surface at ...
(Date:7/25/2014)... and MOSI officially announced a transformational partnership that will unite ... a difference in the Tampa Bay community. Florida Hospital presented ... support needed to keep the science center moving forward. ... Theatre from film to a state-of-the-art digital 3D projection system. ... state of Florida, and it is one of the first ...
(Date:7/25/2014)... 25, 2014 AttorneyOne.com, a recognized authority on ... from the FDA on Ibuprofen and Oxcarbazepine Tablets . ... lot of Ibuprofen and one lot of Oxcarbazepine Tablets, by ... mislabeled packaging. Oxcarbazepine is used for the treatment of certain ... The reason for the recall is that Lot #142588, Expiration ...
Breaking Medicine News(10 mins):Health News:SR22 Insurance for High Risk Motorists Added to Local Quotes System at Insurer Website Online 2Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Sport Court Provides All Sports Flooring for Basketball Events in Chicago and Washington D.C. 2Health News:Florida Hospital Donates a Two Million Dollar Transformational Gift to the Museum of Science and Industry (MOSI) 2Health News:Florida Hospital Donates a Two Million Dollar Transformational Gift to the Museum of Science and Industry (MOSI) 3Health News:Florida Hospital Donates a Two Million Dollar Transformational Gift to the Museum of Science and Industry (MOSI) 4Health News:Ibuprofen and Oxcarbazepine Tablets Recalled: AttorneyOne Monitors and Keep Consumers Informed 2
... leader in customized recruitment leadership, training and outsourcing continues to ... Acosta, Takeda, Praxair, Kronos, Roxanne, ABB, Siemens Candida and others. ... outsourcing (RPO) provider on HRO Today’s annual Baker’s Dozen list. ... ...
... its medical malpractice legal portal to provide legal assistance to the ... derived from medical malpractice. Medical malpractice can affect nearly anyone undergoing ... ... (PRWEB) October 14, 2008 -- LegalView.com, the number one legal resource ...
... All Cash Transaction Expected to Improve Speed-to-Market for Next Generation ... ... BIRMINGHAM, Ala., Oct. 13 Health,Systems Solutions, Inc. (OTC Bulletin Board: ... of a definitive agreement for,HSS to acquire 100% of the stock ...
... Inc. (IPM) today announced it is one of ... by The Wall Street Journal and Winning Workplaces. ... ( www.wsj.com/smallbusiness ). IPM provides project management and ... including the life sciences, food and beverage, healthcare, ...
... Medicaid recipients age 50 and older appear to receive ... according to a report in the October 13 issue ... the JAMA/Archives journals. , These three types ... eliminating disparities in screenings is part of the government,s ...
... with referrals to cardiac rehabilitation, appear to be associated ... according to a report in the Oct. 13, 2008, ... of the JAMA/Archives journals. , Emory University researchers studied ... hospitalization for heart attack. Six months later, 297 of ...
Cached Medicine News:Health News:The RightThing Continues Drive: Completes Strong Q3 2Health News:LegalView Reintroduces its Medical Malpractice Information Portal with Updated Links to Finding Immediate Legal Assistance 2Health News:LegalView Reintroduces its Medical Malpractice Information Portal with Updated Links to Finding Immediate Legal Assistance 3Health News:Health Systems Solutions Enters into Agreement to Acquire Emageon to Create Healthcare Technology Leader 2Health News:Health Systems Solutions Enters into Agreement to Acquire Emageon to Create Healthcare Technology Leader 3Health News:Health Systems Solutions Enters into Agreement to Acquire Emageon to Create Healthcare Technology Leader 4Health News:Health Systems Solutions Enters into Agreement to Acquire Emageon to Create Healthcare Technology Leader 5Health News:Health Systems Solutions Enters into Agreement to Acquire Emageon to Create Healthcare Technology Leader 6Health News: Integrated Project Management Named a "Top Small Workplace" by The Wall Street Journal and Winning Workplaces 2Health News: Integrated Project Management Named a "Top Small Workplace" by The Wall Street Journal and Winning Workplaces 3Health News:Cancer screening rates among older Medicaid patients fall short of national objectives 2
Single round silicone drain with 10 in. hole pattern, 49 in. long...
Silicone Flat Hubless Drains...
Hubbed drains are made of translucent silicone and include a full-length X-ray opaque stripe....
Hubbed drains are made of translucent silicone and include a full-length X-ray opaque stripe....
Medicine Products: