Navigation Links
Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus
Date:10/29/2007

is, where TLRs 7, 8 and 9 are inappropriately activated. As with our other clinical efforts, we are hopeful that we can make a contribution to medicine with a new potential therapy for a disease that today remains a large unmet medical need."

CPG 52364's Mechanism of Action in SLE

The defining characteristic of SLE is the production of autoantibodies, abnormal antibodies produced against the body's own tissues or organs. In SLE, these autoantibodies bind to DNA and/or RNA, and their associated cellular proteins, forming "immune complexes". Immune complexes containing anti-DNA antibodies activate TLR9, while immune complexes that contain RNA activate TLR7 and TLR8.

Recent studies show that the development and progression of SLE are driven by the inappropriate activation of TLR7, TLR8 and TLR9. TLRs7 and 9 are present within B cells, which secrete high levels of interferon-alpha and contribute to disease severity. TLR8 is expressed in monocytes and other dendritic cells, which are thought to produce proinflammatory cytokines, which further contribute to disease process. Other studies have indicated that autoimmunity in rheumatoid arthritis (RA) and psoriasis also is mediated through one or more of these TLRs.

Coley evaluated and selected TLR7, 8 and 9 as important targets by elucidating the therapeutic mechanism of action for a commonly used treatment for SLE and RA. For many years, SLE and RA patients have been treated with certain antimalarial drugs as a treatment for SLE, such as hydroxychloroquine (HCQ), which was serendipitously discovered to be a moderately effective therapy for the disease. The therapeutic mechanism for HCQ in these autoimmune diseases had been unknown, until research from Coley and other scientists revealed that the compound is an antagonist of TLR9, and to a lesser extent TLRs7 and 8.

Based on the new recognition by Coley that the efficacy of HCQ appears to result from blocking TLRs 7, 8 and 9, Coley designed and
'/>"/>

SOURCE Coley Pharmaceutical Group, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
2. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
3. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
5. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
6. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
7. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
8. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
9. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
10. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
11. Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple Myeloma and Waldenstroms Macroglobulinemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... , June 19, 2013   BioCision ... sample standardization and handling in many areas of ... of new patents by the U.S. Patent Office ... products developed to standardize sample handling to ensure ... results in common laboratory procedures. ...
(Date:6/19/2013)... , June 19, 2013 /PRNewswire/ ... has recently added DrugPatentWatch to its ... http://www.bharatbook.com/drugpatentwatch-tour.pdf )      (Logo: ... comprehensive information on pharmaceutical, drug patents ... supports the critical business functions of ...
(Date:6/19/2013)... , June 19, 2013 Amerivet Solutions, ... servicing all branches of government from Federal to ... expanded their facilities to include complex metal design ... fabricated some very complex aluminum parts for the ... expand our capabilities to service government contracts," states ...
Breaking Medicine Technology:BioCision Announces Two New U.S. Patents for Thermo-Conductive Products that Standardize Sample Handling in Laboratory Research 2Drug Patent Watch 2Drug Patent Watch 3Amerivet Solutions Expands to Manufacture Complex Metal Designs 2
(Date:6/19/2013)... 19, 2013 Strict rules for ... 2013, Orriant is launching a new tool to ... compliance with regulations. New HHS regulations will ... incentives if their employer offers outcome-based, health-contingent, compliant ... compliant with these standards for nearly a decade. ...
(Date:6/19/2013)... As Januvia lawsuit ... in courts throughout the U.S., Bernstein Liebhard LLP notes ... held a meeting to discuss the safety of Januvia ... According to a June 12th report from Bloomberg.com, the ... Januvia and similar drugs, following a recent study that ...
(Date:6/19/2013)... (June 19, 2013) In what is believed to ... most common form of hereditary dystonia a movement ... in deep brain stimulation report good success rates and ... the Movement Disorders Program at Cedars-Sinai Medical Center,s Department ... the Division of Neurosurgery at Beth Israel Deaconess Medical ...
(Date:6/19/2013)... reveals significant disparities between minority and white clients ... programs. Moreover, these disparities vary widely from state ... for most states there,s something amiss," says Stephan ... "There are strong racial and ethnic disparities for ... treatment programs successfully, and those disparities are something ...
(Date:6/19/2013)... 19, 2013 The Movement ... neurosurgeons, psychiatrists and urologists with specialists in physical ... works with patients and their family members to ... of life. Patients also have the opportunity to ... research. , “Movement disorders can be relentlessly progressive ...
Breaking Medicine News(10 mins):Health News:New Tool to Increase Participation Rates for Corporate Wellness Programs in July 2013 Will Help Maintain Compliance with Federal Regulations 2Health News:New Tool to Increase Participation Rates for Corporate Wellness Programs in July 2013 Will Help Maintain Compliance with Federal Regulations 3Health News:Januvia Lawsuit News: Bernstein Liebhard LLP Comments on Recent FDA Meeting to Discuss Safety of Januvia and Other Incretin Mimetics 2Health News:Januvia Lawsuit News: Bernstein Liebhard LLP Comments on Recent FDA Meeting to Discuss Safety of Januvia and Other Incretin Mimetics 3Health News:Long-term study reports deep brain stimulation effective for most common hereditary dystonia 2Health News:States vary widely on success rates for minorities in drug treatment programs 2Health News:States vary widely on success rates for minorities in drug treatment programs 3Health News:Abington Memorial Hospital’s Neurosciences Institute Opens Movement Disorders Center 2
... Industries, a,leading manufacturer of specialty vehicles in the United ... production facility in Bluffton,Ohio. Company officials plan to move ... Hutchinson, Kansas by November 9, 2007. "The closure ... was,certainly a difficult decision. Since the purchase of this ...
... Center Suite operates with Gryphon compliance services ... resulting in increased productivity for call centers, ... provider of,intelligent customer interaction solutions, today announced that ... the worldwide leader in,On-Demand Contact Governance solutions. This ...
... of pen-and-paper questionnaires/ , Here is a great ... soon be obsolete! Well, at least for people with ... by doctors. Thanks to the RT3 accelerometer, MS patients ... keeping a journal or completing activity questionnaires. The RT3 ...
... took a weekly dose of risedronate, sold as Actonel, ... take the drug, according to a two-year study from ... week at the 29th annual meeting of the American ... through Wednesday at the Hawaii Convention Center. , Susan ...
... More Than 30 years of Healthcare Management Expertise, ... leader in,Provider Network Management solutions, today announced the ... PacifiCare of California, to its board,of directors. ... of the country,s,largest HMOs is a tremendous asset ...
... In the face of an emerging liver cancer crisis in ... developed a test that could help millions. Due to widespread ... population is at high risk for hepatocellular carcinoma (HCC), a ... treated early. Researchers report on a new blood screening ...
Cached Medicine News:Health News:Company Announces Closure of Bluffton, Ohio Plant 2Health News:Amcat Partners With Gryphon to Provide Comprehensive and Guaranteed Do Not Call (DNC) Compliance Solution for Outbound Contact Activities 2Health News:Amcat Partners With Gryphon to Provide Comprehensive and Guaranteed Do Not Call (DNC) Compliance Solution for Outbound Contact Activities 3Health News:Story tips for journalists 2Health News:Story tips for journalists 3Health News:Weekly dose of osteoporosis drug prevents bone loss after breast cancer treatment 2Health News:Jon R. Wampler Joins Portico Systems' Board of Directors 2Health News:Liver cancer marker could yield blood test for early detection 2Health News:Liver cancer marker could yield blood test for early detection 3Health News:Liver cancer marker could yield blood test for early detection 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: