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Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus
Date:10/29/2007

-- CPG 52364, Coley's First Orally-Available, Small Molecule Drug

Candidate, Enters Phase I Clinical Development --

WELLESLEY, Mass., Oct. 29 /PRNewswire-FirstCall/ -- Coley Pharmaceutical Group, Inc. (Nasdaq: COLY), today announced that it has dosed its first subject in a Phase I safety study of its novel, orally-available TLR Therapeutic(TM) drug candidate for the treatment of Systemic Lupus Erythematosus, or SLE. The candidate, CPG 52364, is a small molecule Toll- Like Receptor (TLR) antagonist designed to specifically inhibit TLRs 7, 8 and 9 and inhibit disease development in SLE and other autoimmune disorders. CPG 52364 has been designed to interfere at an early stage of the immune cascade by blocking the inappropriate immune activation of all three of these TLRs, and to treat the underlying cause of the disease without causing general suppression of immune function.

The Phase I study is a double-blind, placebo-controlled, randomized clinical trial designed to examine the safety, tolerability and pharmacokinetics of ascending doses of CPG 52364. The compound will be administered as a single oral dose in approximately 40 healthy volunteers.

"Coley is committed to innovation in TLR Therapeutic drug development, and we are pleased to have furthered our objective of pipeline diversification by advancing this first-in-class TLR antagonist compound into the clinic," commented Robert L. Bratzler, Ph.D., President and Chief Executive Officer of Coley Pharmaceutical Group. "We believe there is solid preclinical evidence and strong scientific rationale that validate CPG 52364 for the treatment of SLE, and potentially other autoimmune diseases, such as rheumatoid arthritis (RA) and psorias
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SOURCE Coley Pharmaceutical Group, Inc.
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