Navigation Links
Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus
Date:10/29/2007

-- CPG 52364, Coley's First Orally-Available, Small Molecule Drug

Candidate, Enters Phase I Clinical Development --

WELLESLEY, Mass., Oct. 29 /PRNewswire-FirstCall/ -- Coley Pharmaceutical Group, Inc. (Nasdaq: COLY), today announced that it has dosed its first subject in a Phase I safety study of its novel, orally-available TLR Therapeutic(TM) drug candidate for the treatment of Systemic Lupus Erythematosus, or SLE. The candidate, CPG 52364, is a small molecule Toll- Like Receptor (TLR) antagonist designed to specifically inhibit TLRs 7, 8 and 9 and inhibit disease development in SLE and other autoimmune disorders. CPG 52364 has been designed to interfere at an early stage of the immune cascade by blocking the inappropriate immune activation of all three of these TLRs, and to treat the underlying cause of the disease without causing general suppression of immune function.

The Phase I study is a double-blind, placebo-controlled, randomized clinical trial designed to examine the safety, tolerability and pharmacokinetics of ascending doses of CPG 52364. The compound will be administered as a single oral dose in approximately 40 healthy volunteers.

"Coley is committed to innovation in TLR Therapeutic drug development, and we are pleased to have furthered our objective of pipeline diversification by advancing this first-in-class TLR antagonist compound into the clinic," commented Robert L. Bratzler, Ph.D., President and Chief Executive Officer of Coley Pharmaceutical Group. "We believe there is solid preclinical evidence and strong scientific rationale that validate CPG 52364 for the treatment of SLE, and potentially other autoimmune diseases, such as rheumatoid arthritis (RA) and psorias
'/>"/>

SOURCE Coley Pharmaceutical Group, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
2. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
3. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
5. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
6. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
7. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
8. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
9. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
10. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
11. Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple Myeloma and Waldenstroms Macroglobulinemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014  Halozyme Therapeutics, Inc. (NASDAQ: ... enrollment and dosing of patients in its ongoing Phase ... pancreatic cancer under the revised clinical protocol agreed to ... PEGylated form of Halozyme,s proprietary recombinant human hyaluronidase under ... hyaluronan. "Our diligent effort to rapidly ...
(Date:7/22/2014)... -- ConvaTec, a privately-held medical products and technologies company, today ... chief financial officer of the company, effective July 22, ... president and chief financial officer of Elan Corporation, a ... was part of a senior team that helped build ... to Perrigo, a pharmaceutical manufacturer, in December 2013. ...
(Date:7/22/2014)... 22, 2014  UL (Underwriters Laboratories), a global ... Food and Drug Administration (FDA) has recognized two ... medical devices incorporating lithium or nickel-based batteries. The ... Household and Commercial Batteries, and UL 1642 - ... Consensus standards are standards recognized by the FDA ...
Breaking Medicine Technology:Halozyme Resumes Patient Enrollment And Dosing In PEGPH20 Clinical Program In Pancreatic Cancer 2Halozyme Resumes Patient Enrollment And Dosing In PEGPH20 Clinical Program In Pancreatic Cancer 3ConvaTec Names Nigel Clerkin Chief Financial Officer 2Two UL Battery Safety Standards Are now FDA Recognized Consensus Standards for Medical Devices 2
... Women ages 65-69 who break a hip are five times more ... age who don,t break a hip, according to a Kaiser Permanente ... Health and published online today in the Archives of Internal ... by age group. In addition to the finding for women ages ...
... 26, 2011 UHC, an alliance of the nation,s ... a mobile analytics application for Spend LINK®, UHC,s ... subset of Spend LINK® reports that can be ... developed by Novation, UHC,s supply contracting company, allows users ...
Cached Medicine Technology:Elderly Women Who Break a Hip at Increased Risk of Dying Within a Year 2Elderly Women Who Break a Hip at Increased Risk of Dying Within a Year 3Elderly Women Who Break a Hip at Increased Risk of Dying Within a Year 4UHC Launches Analytics Mobile App to Help Members Improve Supply Chain Return on Investment 2UHC Launches Analytics Mobile App to Help Members Improve Supply Chain Return on Investment 3
(Date:7/22/2014)... Print Audit® has released another ... web portal. Facilities Manager 3.1.0R includes fixes for ... as well as numerous new reporting and alerting ... Manager is a powerful, easy to use managed ... reads, automate supplies fulfillment and report service information ...
(Date:7/22/2014)... (PRWEB) July 23, 2014 Recently, iFitDress.com, a ... women, has announced its new selection of white party ... announced that custom made outfits are now available on its ... order before the end of July can get a discounted ... company’s products are popular among international customers, so its marketing ...
(Date:7/22/2014)... Provectus has started leading ... on, in addition to working with the long known ... Glass as well as the creation of services for ... lifestyle requires special gadgets for work, leisure and business. ... in healthcare, logistics, travelling, sports, education, science and other ...
(Date:7/22/2014)... 2014 DocbookMD , a HIPAA-secure ... one of the largest physician-centric mobile communication solutions in ... in Houston. , Created by Austin-based physicians, Tracey Haas, ... will be embedded into MHMD’s Accountable Care Network to ... best technology to put this capability at the fingertips ...
(Date:7/22/2014)... Mona Khan Company today announced the ... 16th, 2014, at the Blanks Studio in Sherman Oaks, ... Bollywood workout was launched in the San Francisco Bay ... culture, Bombay Jam® is a dance-based total body workout ... with authentic Bollywood flavor. Instructor trainings have been available ...
Breaking Medicine News(10 mins):Health News:Print Audit® Releases Facilities Manager 3.1.0R 2Health News:Elegant White Party Dresses Now Provided by Distinguished Company iFitDress.com 2Health News:Provectus Announces Development for Google Glass and Wearables 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 4Health News:Mona Khan Company Announces Bombay Jam® Instructor Certification in Los Angeles in August 2014 2Health News:Mona Khan Company Announces Bombay Jam® Instructor Certification in Los Angeles in August 2014 3
... Hospital (MGH) supports previous reports that adolescents with bipolar ... abuse. The article appearing in the June Drug ... to date and the first to include a control ... of the risk conferred by other disorders affecting study ...
... June 2, 2008--A recent study published in Pediatrics and ... Public Health found that sugar-sweetened beverages (SSBs) are an ... Teens who consume SSBs, which include sodas, fruit drinks ... 356 calories per day, a significant increase from 10 ...
... ST. PETERSBURG, Fla., June 2 The Advanced,Wound Management ... announced,today that its negative pressure wound therapy (NPWT) products ... areas included in the,first phase of the competitive bidding ... (CMS) in the U.S. The program, which is,scheduled to ...
... Developers Kit that allows for easy ... integration to other applications, PITTSBURGH, ... maintenance management software (CMMS) provider,for the healthcare industry announces TMS ... TMS automatically., The TMS Connect application serves as the ...
... ... National Safety Month, CHICAGO, June 2 Protecting children during ... block.,However, during the summer months, mowing the lawn can be as ... if proper safety,precautions are not taken. In fact, nearly 210,000 people ...
... 2008, the Netherlands Organisation for Scientific Research (NWO) announced ... 2008. The prize is the highest Dutch award in ... spent on research of their choice. The researchers receive ... scientific work. , The winners of the NWO/Spinoza Prize ...
Cached Medicine News:Health News:Report confirms increased risk of smoking, substance abuse in bipolar adolescents 2Health News:Children's consumption of sugar-sweetened beverages 2Health News:Children's consumption of sugar-sweetened beverages 3Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 2Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 3Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 4Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 5Health News:Four Rivers Software Announces Enhanced Product Offering: TMS Connect(TM) 2Health News:More Than Sun Block Required to Protect Kids While Mowing Lawns 2Health News:More Than Sun Block Required to Protect Kids While Mowing Lawns 3Health News:More Than Sun Block Required to Protect Kids While Mowing Lawns 4Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 2Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 3Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 4Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 5Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 6Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 7Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 8Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 9Health News:NWO/Spinoza Prize for literature, microbiology, physics and medicine 10
... Arctic Circler uses the same cryoconsole ... AF originating in the pulmonary veins. Arctic ... challenge the traditional palliative-only treatments that rely ... the Arctic Circler catheter has the ability ...
... The Guglielmi Detachable Coil is intended for: ... because of,their morphology, their location, or the ... by the treating,neurosurgical team to be a) ... operative techniques, or b) inoperable.,The GDC is ...
Care must be taken to operate the power unit slowly to help eliminate the possibility of breaking the wires by over-tightening....
Large solid mallet with patented Ortho-Grip® silicone rubber handle....
Medicine Products: