Navigation Links
Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia
Date:11/11/2008

(HDL) or "good" cholesterol (p<0.01). These study arm findings also produced statistically significant placebo-corrected reductions from baseline in total cholesterol (7 percent; p<0.01), apolipoprotein B (8 percent; p<0.01) and non-HDL cholesterol (11 percent; p less than or equal to 0.0001) as well as an increase in apolipoprotein A-I (7 percent; p<0.01). There was a non-significant, placebo-adjusted, 5.1 percent median increase in triglyceride levels. Compliance rates for patients receiving colesevelam HCl 3.75 g/day in the study at the completion of the double-blind period was 87 percent.

"Treatment with colesevelam HCl in pediatric patients with inherited high cholesterol significantly reduced their LDL or 'bad' cholesterol and increased the HDL or 'good' cholesterol. This was seen in children who received colesevelam HCl alone or combined with a statin, demonstrating the additive effect on LDL-cholesterol reduction that is offered by colesevelam HCl therapy," said Evan A Stein MD PhD, Director, Metabolic & Atherosclerosis Research Center, Cincinnati, OH. "Current guidelines support the need for and benefits of lowering LDL cholesterol in children with heterozygous familial hypercholesterolemia."

According to the American Academy of Pediatrics (AAP), high cholesterol is a growing problem among children in the United States. In the AAP's Child and Adolescent Trial for Cardiovascular Health, 13.3 percent of children in the fourth grade had total cholesterol concentrations of greater than 200 mg/dL.(4) The current NCEP guidelines for total cholesterol in children ages 2 to 18 years of age is less than 170 mg/dL, with high cholesterol identified as greater than 200 mg/dL.(5) The AAP also recently published a statement recommending that cholesterol lowering medications should be considered for children who are more than eight years old and have high LDL concentrations.(6)

Colesevelam HCl, marketed as Welchol(R), is the first and only medication
'/>"/>

SOURCE Daiichi Sankyo, Inc. (DSI)
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Photo: Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes
2. Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated
3. Leading Cardiologist Joins Ontario Research Firm to Conduct New Clinical Trial on the Effect of Pantethine on Cholesterol Levels
4. VAP Cholesterol Test Helps Reveal Association Between Adiponectin Levels and Atherosclerosis
5. Fish Oil and Red Yeast Rice Studied for Lowering Blood Cholesterol
6. Blueberry-Supplemented Diet Shows Promise in Lowering Cholesterol in Animal Trials
7. People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels
8. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
9. New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol
10. Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary
11. Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...tlinker.comannouncesthatanewmarketresearchreportis...ent-AGlobalMarketPerspective ,, http://www.r...-Global-Market-Perspective.html ,, Risingincid...ngnationsisaprincipalfactorinfluencinggrowthinthem...breastcancerhasallowedwomentocomeforwardfortheirye...
(Date:11/25/2009)...ire/--SwissrayInternational,Inc.aleadingmanufactur...edtodaythatitsoperationshavebeenacquiredbyaprivate...ay,smedicalimagingbrand.Theacquisitionincludedalla...nventory.After25yearsofsuccessandgrowthSwissrayisn...mentswithstableandsteadygrowth. ,, "Swissrayhas...
(Date:11/25/2009)...all/--NuVasive,Inc.(Nasdaq: NUVA ),amedicaldevicec...ptivesurgicaltreatmentsforthespine,announcedtodayt...09,at5:30p.m.ET/2:30p.m.PT.Theconferencecallwillfo...pany,sproductsandwillincludecommentsfrommanagement...nnumbersare1-877-407-4018fordomesticcallersand1-20...
Breaking Medicine Technology:Reportlinker Adds Mammography Equipment - A Global Market Perspective 2Reportlinker Adds Mammography Equipment - A Global Market Perspective 3Reportlinker Adds Mammography Equipment - A Global Market Perspective 4Reportlinker Adds Mammography Equipment - A Global Market Perspective 5Reportlinker Adds Mammography Equipment - A Global Market Perspective 6Reportlinker Adds Mammography Equipment - A Global Market Perspective 7Swissray International Announces New Ownership 2NuVasive Announces Conference Call and Webcast Regarding Reimbursement 2NuVasive Announces Conference Call and Webcast Regarding Reimbursement 3Urgent Message 3A UniCare Exiting Illinois Commercial Health Insurance Market 61769 1Urgent Message 3A UniCare Exiting Illinois Commercial Health Insurance Market 61769 2National Medical Association Response to U S Preventive Services Task Force Recommendations 61766 1American BioSciences Rebuts Misleading Statements Made by Hungarian Competitor 14925 1American BioSciences Rebuts Misleading Statements Made by Hungarian Competitor 14925 2
...Immune, a,clinical stage nanomedicine company focu...ltifunctional, tumor-targeted therapies has,been s...merican,Society of Clinical Oncology Annual Meetin...n will take place from 8:00 am to 12,noon on June ...esent the poster abstract entitled "Preliminary Re...
...ence Shows ONCONASE Uptake in,Cells Differs from o...ewswire-FirstCall/ --,Alfacell Corporation today a... the pathway that ONCONASE (ranpirnase) follows to...cience (2007; 120: 1405-1411),a paper based on st...in and the University of Montpellier II in France ...
Other Medicine Technology:CytImmune To Present At ASCO Phase I Clinical Trial of CYT-6091 to,be Presented on June 3, 2007 2Researchers Identify Intracellular Pathway of Alfacell's Onconase 2Researchers Identify Intracellular Pathway of Alfacell's Onconase 3
(Date:11/27/2009)...g rates to bring unprecedented medical, economic b...27 (HealthDay News) -- The number of people with d... over the next 25 years, a new study predicts. ,... million people with the disease, up from 23.7 mil...eating people with diabetes will triple, the study...
(Date:11/27/2009)... Voyant Health™ announced...n) has licensed its TraumaCad Enterprise orthopedi...kflow solution. , (PRWEB)...ed today that Spectrum Health (Grand Rapids, Michi...dic templating solution and its TraumaCad Extend w...
(Date:11/27/2009)... Specialist manufacturers who u...ts are saving millions of dollars by bringing in t...ess. Increasing numbers of pro-active medical manu... at the concept stage of their projects, ensuring ...design processes or potentially outdated technolog...
(Date:11/26/2009)..., NEWYORK,Nov.27/PRNewswire/--Withcoldandfluseason...cestocontrolthespreadofinfectionsandavoidillness. ...althy,buttoavoidtransmittingillnessifwe,resick,"sa...trol),nursingdirectorforinfectioncontrolandoccupat...ttan. ,, HospitalforSpecialSurgeryhasoneofthelo...
(Date:11/26/2009)...he next 25 years, the number of Americans living w...3.7 million in 2009 to 44.1 million in 2034. Over ...triple, rising from $113 billion to $336 billion, ..., researchers based at the University of Chicago r... The number of those with diabetes covered by Med...
Breaking Medicine News(10 mins):Health News:Diabetes Cases Expected to Double in 25 Years 2Health News:Diabetes Cases Expected to Double in 25 Years 3Health News:Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend 2Health News:Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend 3Health News:Pro-active Manufacturers Save Millions with Advanced Flintec Medical Load Cells 2Health News:Pro-active Manufacturers Save Millions with Advanced Flintec Medical Load Cells 3Health News:Pro-active Manufacturers Save Millions with Advanced Flintec Medical Load Cells 4Health News:Infection-Control Strategies at Leading Hospital Can be Adapted for Everyday Use 2Health News:Infection-Control Strategies at Leading Hospital Can be Adapted for Everyday Use 3Health News:Diabetes cases to double and costs to triple by 2034 2Health News:Diabetes cases to double and costs to triple by 2034 3
...ound that the deadly strain H5N1 strain of bird fl...dead chickens found in Siberia all infected with t...d that all the five dead chickens were from Omsk r...ov, the centre's general director said that the de...
...s decided to go ahead with implementing some refor... being the merger of the three ambulance services ...he idea in integrating the services is that it wil...de redundant, the frontline services are expected ...
...stroke") affects 300, 000 Americans each year. A p...have subsided by the time they reach an emergency ...from a major stroke in 90 days with 64 percent hav...rgency Medicine Annual Meeting, May 18-21, 2006 in...
...ajor Thales has signed a pact with the foreign min...highly// qualified postgraduates from India and Ch...rant of at least $12,700 per annum depending on th... will be invited to follow an advanced specialised...
...et themselves screened for HIV, city-run medical c...for HIV testing. According to the new rule, counse...neccessary for voluntary HIV/AIDS testing. All tha...unseling. Two hospitals and city clinics that test...
...blic health probelm in the U.S. A U.S. government ...s with drug addiction// problems will double to ap...early 2.5 million Americans have been said to have...an be partly blamed for the present trend, and an ...
Other Medicine News:Health News:Prompt Diagnosis Could Be Life-Saving In Mini-Strokes 2
HighTide Diabetic
Cam Walker® II
AnkleWALKER™ by DJ!
...e is designed for the treatment of diaphyseal frac...n provides post operative support following intra ...nal fixation. The brace allows for movement of joi...vascularity and encouraging bone growth. For a mor...
Medicine Products: