Navigation Links
Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia
Date:11/11/2008

(HDL) or "good" cholesterol (p<0.01). These study arm findings also produced statistically significant placebo-corrected reductions from baseline in total cholesterol (7 percent; p<0.01), apolipoprotein B (8 percent; p<0.01) and non-HDL cholesterol (11 percent; p less than or equal to 0.0001) as well as an increase in apolipoprotein A-I (7 percent; p<0.01). There was a non-significant, placebo-adjusted, 5.1 percent median increase in triglyceride levels. Compliance rates for patients receiving colesevelam HCl 3.75 g/day in the study at the completion of the double-blind period was 87 percent.

"Treatment with colesevelam HCl in pediatric patients with inherited high cholesterol significantly reduced their LDL or 'bad' cholesterol and increased the HDL or 'good' cholesterol. This was seen in children who received colesevelam HCl alone or combined with a statin, demonstrating the additive effect on LDL-cholesterol reduction that is offered by colesevelam HCl therapy," said Evan A Stein MD PhD, Director, Metabolic & Atherosclerosis Research Center, Cincinnati, OH. "Current guidelines support the need for and benefits of lowering LDL cholesterol in children with heterozygous familial hypercholesterolemia."

According to the American Academy of Pediatrics (AAP), high cholesterol is a growing problem among children in the United States. In the AAP's Child and Adolescent Trial for Cardiovascular Health, 13.3 percent of children in the fourth grade had total cholesterol concentrations of greater than 200 mg/dL.(4) The current NCEP guidelines for total cholesterol in children ages 2 to 18 years of age is less than 170 mg/dL, with high cholesterol identified as greater than 200 mg/dL.(5) The AAP also recently published a statement recommending that cholesterol lowering medications should be considered for children who are more than eight years old and have high LDL concentrations.(6)

Colesevelam HCl, marketed as Welchol(R), is the first and only medication
'/>"/>

SOURCE Daiichi Sankyo, Inc. (DSI)
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Photo: Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes
2. Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated
3. Leading Cardiologist Joins Ontario Research Firm to Conduct New Clinical Trial on the Effect of Pantethine on Cholesterol Levels
4. VAP Cholesterol Test Helps Reveal Association Between Adiponectin Levels and Atherosclerosis
5. Fish Oil and Red Yeast Rice Studied for Lowering Blood Cholesterol
6. Blueberry-Supplemented Diet Shows Promise in Lowering Cholesterol in Animal Trials
7. People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels
8. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
9. New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol
10. Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary
11. Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 24, 2013 3SBio Inc. (NASDAQ: ... a leading China -based biotechnology ... biopharmaceutical products, announced today that, at an extraordinary ... shareholders voted in favor of the proposal to ... plan of merger dated February 8, 2013, among ...
(Date:5/23/2013)... 23, 2013  Haemonetics Corporation (NYSE: HAE ) ... & EVP-Business Development, will present at The Deutsche Bank 38 ... Boston, MA on May 29, 2013 at 1:30pm ... The public may access Mr. Lindop,s presentation live ... Haemonetics Haemonetics (NYSE: HAE ) is ...
(Date:5/23/2013)... Tenn. , May 23, 2013  TeamHealth ... 24-hour nurse triage and nurse advice lines, announces ... committee, comprising physician, nursing and administrative leaders, provides ... safe, quality and cost-effective services for hospital clients, ... our national healthcare system evolves, it,s imperative to ...
Breaking Medicine Technology:3SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3TeamHealth Medical Call Center Forms Clinical Advisory Committee 2
... 17, 2011 inVentiv Health, offering best-in-class clinical, ... today announced it has signed a definitive agreement ... of global drug development services to the pharmaceutical, ... terms of the transaction were not disclosed. ...
... Ky. and MOUNT ARLINGTON, N.J., May 17, 2011 ... Egros has been appointed to the position of Chief ... Executive Officer. Fabrice Egros has more than ... prior to Xanodyne served in various senior positions in ...
Cached Medicine Technology:inVentiv Health to Acquire PharmaNet 2inVentiv Health to Acquire PharmaNet 3inVentiv Health to Acquire PharmaNet 4inVentiv Health to Acquire PharmaNet 5Xanodyne Pharmaceuticals Appoints New Chief Operating Officer 2
(Date:5/24/2013)... DePuy ASR lawsuit claims ... move forward in courts throughout the country, Bernstein Liebhard ... San Francisco Superior Court on April 25th, a Plaintiff ... DePuy hip lawsuit is voluntarily seeking dismissal of the ... No. CGC11508806; Calif. Super. Ct., San Francisco). , “This ...
(Date:5/24/2013)... HealthDay Reporter , , FRIDAY, May 24 (HealthDay News) ... remarkable. But it was a physical challenge in her ... her sport. "I was an 11-year-old girl with ... was diagnosed by my orthopedic surgeon," said Lewis, who ... Society and the American Academy of Orthopaedic Surgeons so ...
(Date:5/24/2013)... -- Patients hospitalized for heart failure appear to have ... or in the morning, a new study finds. ... heart failure patients admitted in January, on Fridays and ... present their findings Saturday in Portugal at the annual ... Society of Cardiology. "The fact that patients ...
(Date:5/24/2013)... Western University of Health Sciences’ College ... Accreditation” for the next seven years from the American ... “This is a magnificent achievement, and one we expected ... outcomes,” said College of Veterinary Medicine Dean Phillip Nelson, ... the faculty, staff, preceptors, and students that participated in ...
(Date:5/24/2013)... ResortQuest Real Estate® is proud to announce ... at the firm’s Bethany Beach location. , Originally from ... in 1975. Her real estate career began in 1987 ... the real estate business - receptionist, cleaning coordinator, director ... licensed sales associate. , “I am delighted to ...
Breaking Medicine News(10 mins):Health News:DePuy ASR Hip Lawsuit News: Bernstein Liebhard LLP Notes Request for Voluntary Dismissal in California DePuy Hip Recall Case 2Health News:DePuy ASR Hip Lawsuit News: Bernstein Liebhard LLP Notes Request for Voluntary Dismissal in California DePuy Hip Recall Case 3Health News:DePuy ASR Hip Lawsuit News: Bernstein Liebhard LLP Notes Request for Voluntary Dismissal in California DePuy Hip Recall Case 4Health News:Top-Ranked Golfer Beats Scoliosis 2Health News:Top-Ranked Golfer Beats Scoliosis 3Health News:Monday Best Time for Hospitalization With Heart Failure, Study Says 2Health News:Tammy Mushrush Joins ResortQuest Real Estate® and the Dayna Feher Team 2
... to Visit Washington, D.C., and Meet with Elected Officials, ... will travel to Washington, D.C., this April 1 to ... of the,Americans with Disabilities Act, support for epilepsy public ... Serwik, 7, is one of 50 young people ...
... Visit Washington, D.C., and,Meet with Elected Officials, ... Nicklaus Schliesmann of Holmen will travel to Washington,D.C., ... and gain their,support for restoration of the Americans ... and more research toward a cure for,epilepsy., ...
... D.C., and Meet with Elected Officials, WASHINGTON, March ... travel to Washington, D.C., this April 1 to meet ... the,Americans with Disabilities Act, support for epilepsy public health,programs ... Smith, 15, is one of 50 young people with ...
... Corporation,(NYSE: STE ) today announced that its ... to $300 million in shares of STERIS common ... as of,February 29, 2008. This share repurchase authorization ... remaining. Through March,13, 2008, the Company has repurchased ...
... in Handling Credit ... Fraud, ... he has reached a settlement with TransUnion over his,lawsuit against the credit ... is the first of six credit reporting companies and banks,which Drew has ...
... LINTHICUM, Md., March 13 Dialysis Corporation,of America ... that it will begin,hosting conference calls in conjunction ... The conference call will he held,Friday morning, March ... interested may dial in at 800-750-4984 using pass-code ...
Cached Medicine News:Health News:Delaware Youth Named National Epilepsy Spokesperson 2Health News:Wisconsin Youths Named National Epilepsy Spokespersons 2Health News:South Carolina Youth Named National Epilepsy Spokesperson 2Health News:STERIS Corporation Announces New $300 Million Share Repurchase Authorization 2Health News:STERIS Corporation Announces New $300 Million Share Repurchase Authorization 3Health News:Leukemia Survivor Reaches Landmark Settlement With TransUnion in ID Theft Case 2Health News:Dialysis Corporation of America Earnings Call Reminder 2
... dryer is an electrophoresis gel vacuum dryer that ... dries these gels onto cellophane or filter paper ... elements which heat gels from above. The drying ... V unit includes power cord, porous gel support, ...
... constant voltage power supply, the 105 is very ... range switch control the output, which is variable ... One, two-position switch toggles the bright LED display ... 105 is equipped with an over current detector ...
... simple techniques such as submarine electrophoresis and ... IEF, the Series 90 Programmable Power Supplies ... 90 Programmable Power Supplies are available in ... 6000V., All models operate in constant voltage, ...
MP-250N and 300N is a new style power supply. It is a versatile microprocessor power supply for horizontal or vertical gel electrophoresis. The unit is programmable and offers constant voltage and co...
Medicine Products: