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CoDa Therapeutics' NEXAGON® Wound Healing Gel Named to Windhover's 'Top 10 HOT SPACE Projects to Watch'
Date:9/17/2010

ronic wounds, scarring, abnormal scarring, inflammation and pain, fibrosis, surgical adhesions, and orthopedic procedures, as well as combination therapies and improved medical devices. For further information, please visit www.codatherapeutics.com.

About NEXAGON® The active ingredient in NEXAGON®, which has been shown to work across a wide variety of tissues, is CODA001, a natural, unmodified antisense oligonucleotide that down-regulates the key gap junction protein connexin43 to dampen inflammatory responses and enhance healing.  Data shows that for optimal healing connexin43 is normally dialed-down at the edges of acute wounds (i.e., wounds that will heal normally).  Conversely, other company data demonstrate that connexin43 is wrongly up-regulated at the edge of chronic wounds (i.e., wounds that are slow or difficult to heal such as venous and diabetic ulcers).  CoDa believes that one can better target available medical options and design more effective wound-healing alternatives by devising a therapeutic approach based on biological mechanisms naturally at work or conversely, at fault, in a given situation. The answer is thought to lie in connexin43, which can be seen as a "master switch" in wound healing that is temporarily turned "off" for superior healing of acute wounds, and when left "on" can lead to the unwanted inflammation and/or stalled healing characteristic of chronic wounds.

About Scisive Consulting, LPScisive Consulting, LP, is provides management consulting services for healthcare businesses. It offers strategy development services for innovation sourcing, new market entry, portfolio rationalization, life-cycle management, product line and therapeutic area diversification, clinical development and commercialization, pricing, marketing channels and product launches, and transformational acquisitions projects. The company al
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