Navigation Links
Clinical Update - Debio 0614 (Istaroxime) in Acute Heart Failure
Date:4/2/2008

LAUSANNE, Switzerland, and POMEZIA, Italy, April 2 /PRNewswire/ --

- Presentation of Phase IIa Efficacy Results

Debiopharm Group (Debiopharm), a global independent biopharmaceutical development specialist focusing on serious medical conditions, particularly oncology and cardiology, and sigma-tau Industrie Farmaceutiche Riunite SpA (sigma-tau), a leading Italian pharmaceutical group, today presented positive efficacy results of a phase IIa Horizon-HF study with Debio 0614 (formerly PST2744), also known as istaroxime, in development for the treatment of acute heart failure. Data showed that Debio 0614 is able to significantly reduce pulmonary congestion in patients admitted with worsening heart failure and left ventricular dysfunction. These findings were presented at the 57th American College of Cardiology (AAC) Annual Meeting in Chicago, by Mihai Gheorghiade, Professor of Medicine and Surgery at Northwestern University, Chicago and chair of the steering committee of the study.

The results of the study demonstrated that in patients with decompensated heart failure, Debio 0614 improves hemodynamics and diastolic function, without adversely affecting neurohormones or renal function. In this randomized, double-blind, placebo-controlled, multicenter trial, 120 patients were admitted with worsening heart failure, with a left ventricular ejection fraction below 35% and a pulmonary capillary wedge pressure above 20 mmHg. In 30 patients who received three doses of Debio 0614 over six hours, a statistically significant decrease of pulmonary wedge pressure (p<0.03 for all doses) was observed, with a reduction of the left ventricular diastolic volume (p=0.02 for the highest dose) and an increase in cardiac index (p=0.04 for the highest dose), compared to patients treated with placebo.

"Debio 0614 is a novel intravenous agent combining inotropic and lusitropic properties. Its innovative mechanism of action allows for improving systolic and dias
'/>"/>

SOURCE The Debiopharm Group
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
10. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
11. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2009)..., , NEW YORK, Dec. 2 ...rch report is available in its catalogue: ,, ...rkets ,, http://www.reportlinker.com/p016682...arkets.html ,, Offer a comprehensive view of t...basis ,, Provide an overview of the major types...
(Date:12/2/2009)..., , ST. LOUIS, Dec. 2 /PRNewswire-FirstCall/...ounced that that it has entered into an employment...ive Officer David A. Van Vliet with a term through...terim President and Chief Executive Officer since ...ides continuity of senior leadership as the Compan...
(Date:12/2/2009)..., , NEW YORK, Dec. 2 ...arch report is available in its catalogue: ,, ...rket Trends ,, http://www.reportlinker.com/...lobal-Market-Trends.html ,, Global pharma in...creasing competition in generic markets, rising co...
Breaking Medicine Technology:Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 2Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 3Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 4Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 5Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 6Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 7Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 8Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 9Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 10Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 11Reportlinker Adds Cardiovascular Devices: Technologies and Global Markets 12KV Pharmaceutical Enters Into Employment Agreement with Interim President and Chief Executive Officer David A. Van Vliet 2Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 2Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 3Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 4Reportlinker Adds Pharmaceutical Contract Manufacturing - Global Market Trends 5UCR plant scientists research spawns new discoveries showing how crops survive drought 10793 1UCR plant scientists research spawns new discoveries showing how crops survive drought 10793 2UCR plant scientists research spawns new discoveries showing how crops survive drought 10793 3UCR plant scientists research spawns new discoveries showing how crops survive drought 10793 4Late Preterm Births Increasing in U S 61635 1Late Preterm Births Increasing in U S 61635 2Late Preterm Births Increasing in U S 61635 3Phillies Pitcher Jamie Moyer and Wife Karen Bring Bereavement Camp for Kids to Orange County 61631 1Phillies Pitcher Jamie Moyer and Wife Karen Bring Bereavement Camp for Kids to Orange County 61631 2Phillies Pitcher Jamie Moyer and Wife Karen Bring Bereavement Camp for Kids to Orange County 61631 3Phillies Pitcher Jamie Moyer and Wife Karen Bring Bereavement Camp for Kids to Orange County 61631 4
...HAGEN, Denmark; April 25, 2007 - Genmab A/S (CSE: ...I study with,ofatumumab (HuMax-CD20™) in pat...epted for oral presentation at the 2007,Annual Eur...resentation, which will include new results from t... with ofatumumab, along with data,from the previou...
...STON, N.J.--(BUSINESS WIRE)--Apr 26, 2007 - Columb...ed that preliminary,results from the ongoing data ...cebo-controlled, double-blind Phase III clinical,t... prevention of,preterm birth in women with a previ...has revealed a possible effect of PROCHIEVE 8%,in ...
Other Medicine Technology:Columbia Laboratories Reports Preliminary Findings from the Ongoing,Data Analysis of the Phase III Clinical Study of PROCHIEVE 8%,(progesterone gel) to Prevent Preterm Birth 2Columbia Laboratories Reports Preliminary Findings from the Ongoing,Data Analysis of the Phase III Clinical Study of PROCHIEVE 8%,(progesterone gel) to Prevent Preterm Birth 3
(Date:12/3/2009)... , WALTHAM, Mass., Dec. 2 /PRNewswire/ -...leading laundry room monitoring system at colleges...significantly improved the user experience for the...ow meets HTML Best Practices published by the St...the Federal Government and the World Wide Web Con...
(Date:12/3/2009)...ther healthcare professionals specialising in soli...dvice to guide them through the complex clinical i...c. , The paper, published online by the Americ... stay alert to the significant concerns that swine... even bird flu (H5N1), to develop into a strain wi...
(Date:12/3/2009)...ows it cut risk factors linked to diabetes, cardio...3 (HealthDay News) -- Breast-feeding, even for ju...oman,s risk of metabolic syndrome -- a dangerous c...r, reports a new study appearing online Dec. 3 in ...ave pregnancy-related (gestational) diabetes, brea...
(Date:12/3/2009)... The Lifestyle Advisors at Virtual Spa, m...e the stress of finding that perfect gift this hol...ments in health, fitness and wellness that can be ... within budget. , (PRWEB)...p (mSS), has gathered an assortment of holiday gi...
(Date:12/3/2009)... Mailing a five pound gift anywhere in th...tage. Now the worldwide postage is free when you ...rchased online at www.oakanahouse.com . , ...ing a five pound gift to Paris, Perth or Punjab ca...that,s 40 dollars they can keep in their pocket wh...
Breaking Medicine News(10 mins):Health News:LaundryView(R) Makes Doing Laundry More Convenient for the Visually Impaired 2Health News:LaundryView(R) Makes Doing Laundry More Convenient for the Visually Impaired 3Health News:Transplant infectious disease experts provide pandemic guidance 2Health News:Transplant infectious disease experts provide pandemic guidance 3Health News:Breast-Feeding Can Help Mom's Heart Decades Later 2Health News:Breast-Feeding Can Help Mom's Heart Decades Later 3Health News:Bring Spa Home for the Holidays at mySpaShop & Celebrate Recipes for Personal Spa Treatments 2Health News:Bring Spa Home for the Holidays at mySpaShop & Celebrate Recipes for Personal Spa Treatments 3Health News:Bring Spa Home for the Holidays at mySpaShop & Celebrate Recipes for Personal Spa Treatments 4Health News:Greg Lawson Americana Photography Gift Books Now Offered with Free Shipping Worldwide 2
... STI ) announced today a turn-key Consumer-Direct... to take control of their healthcare costs. The,Su...istrative and financial,components, including a he...partner. , "SunTrust is committed to providi...
...ter Educational Symposium February 5-8, 2009 at th...NM, the American College of Nuclear Physicians (AC...ACNM) unite to create a fused meeting, offering at...ting are exceptional," said Robert W. Atcher, Ph.D...
...en with,autism is wreaking havoc on family finance...rm care and security, according to a new study, Li...nd Massachusetts Mutual Life Insurance,Company (Ma...the pervasiveness of,this public health crisis," s...
...from the current economic crisis in this country, ... look at spending. As experienced by the incompara...rgery, Inc., a recent shift in choices reveals a ...ted & well-to-do patients. , , (Logo: h...
...may very well be the most wonderful time of year, ...nsidered the most dangerous. Everpure LLC, the wor...tems, offers several products for consumers that h...sy to forgo our healthy routines and indulge in th...
... leader in disease prevention services, commends P...r Senate Majority Leader Tom Daschle (D-SD) to hea.... , , (Logo: http://www.newscom.com/cgi-bin/...l time in our nation,s history," stated Christophe...
Other Medicine News:Health News:SunTrust Introduces Health Savings Accounts for Employers Seeking to Take Control of Healthcare Costs 2Health News:SunTrust Introduces Health Savings Accounts for Employers Seeking to Take Control of Healthcare Costs 3Health News:SNM's Mid-Winter Educational Symposium for nuclear medicine and molecular imaging professionals 2Health News:New Easter Seals-MassMutual Study: Autism Strains Family Finances, Threatens Long-Term Care and Security 2Health News:New Easter Seals-MassMutual Study: Autism Strains Family Finances, Threatens Long-Term Care and Security 3Health News:Budget-Beauty for the Rich & Famous 2Health News:Budget-Beauty for the Rich & Famous 3Health News: Drinking Lots of Water Can Help Keep Holiday Weight Gain at Bay : Everpure Water Filtration Products Offer Festive Ways to Stay Healthy This Season 2Health News:U.S. Preventive Medicine Praises Selection of Tom Daschle to Serve as Secretary of Health and Human Services 2
Multi-functional spectral transmittance meter
AIT-350W instrument table
AIT-15 instrument table
Topcon ACP-8R Chart Projector
Medicine Products: