Navigation Links
Clinical Update - Debio 0614 (Istaroxime) in Acute Heart Failure
Date:4/2/2008

LAUSANNE, Switzerland, and POMEZIA, Italy, April 2 /PRNewswire/ --

- Presentation of Phase IIa Efficacy Results

Debiopharm Group (Debiopharm), a global independent biopharmaceutical development specialist focusing on serious medical conditions, particularly oncology and cardiology, and sigma-tau Industrie Farmaceutiche Riunite SpA (sigma-tau), a leading Italian pharmaceutical group, today presented positive efficacy results of a phase IIa Horizon-HF study with Debio 0614 (formerly PST2744), also known as istaroxime, in development for the treatment of acute heart failure. Data showed that Debio 0614 is able to significantly reduce pulmonary congestion in patients admitted with worsening heart failure and left ventricular dysfunction. These findings were presented at the 57th American College of Cardiology (AAC) Annual Meeting in Chicago, by Mihai Gheorghiade, Professor of Medicine and Surgery at Northwestern University, Chicago and chair of the steering committee of the study.

The results of the study demonstrated that in patients with decompensated heart failure, Debio 0614 improves hemodynamics and diastolic function, without adversely affecting neurohormones or renal function. In this randomized, double-blind, placebo-controlled, multicenter trial, 120 patients were admitted with worsening heart failure, with a left ventricular ejection fraction below 35% and a pulmonary capillary wedge pressure above 20 mmHg. In 30 patients who received three doses of Debio 0614 over six hours, a statistically significant decrease of pulmonary wedge pressure (p<0.03 for all doses) was observed, with a reduction of the left ventricular diastolic volume (p=0.02 for the highest dose) and an increase in cardiac index (p=0.04 for the highest dose), compared to patients treated with placebo.

"Debio 0614 is a novel intravenous agent combining inotropic and lusitropic properties. Its innovative mechanism of action allows for improving systolic and dias
'/>"/>

SOURCE The Debiopharm Group
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
10. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
11. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... 2014  Tokyo-based Atonarp Inc. announced today $8 ... by Walden Riverwood Ventures with participation from other ... Smart Spectrometer technology platform, which will enable a ... the oil & gas and healthcare industries for ... to partner with Atonarp in pursuing the commercialization ...
(Date:8/19/2014)... , Aug. 19, 2014 Avizia, Inc., a ... it has closed an equity financing round led by ... Capital. The new funding will be used to continue ... financing round, Avizia welcomes Edward Kennedy , CEO ... directors. He joins Leonard Kurtzman , CFO of ...
(Date:8/19/2014)... Aug. 19, 2014  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) ... , Sanofi and Regeneron will host an IR Thematic ... Tuesday, September 2, 2014 , Baird 2014 Healthcare ... 3, 2014 , Citi,s 9 th Annual ... September 4, 2014 , Morgan Stanley Global Healthcare ...
Breaking Medicine Technology:Atonarp Inc. Raises $8M Series A Round Led by Walden Riverwood Ventures 2Avizia Closes Funding Round 2
(Date:8/20/2014)... In a recent article published by the ... (UCL) study showed that dental experts from around the ... was the most effective. Analysis of 66 different advice ... frequently recommended, but none were favored by a majority. ... experienced cosmetic dentist Dr. Patrick J. Broome, DMD, ...
(Date:8/20/2014)... August 20, 2014 Hope For The ... Hope® Celebration to be hosted in Washington, DC on ... Club. This signature event honors the courage of our ... the fallen. Proceeds from the Got Heart, Give Hope® ... nonprofit dedicated to restoring a sense of self, restoring ...
(Date:8/20/2014)... WA (PRWEB) August 20, 2014 No matter ... always count on a steady set of friends to be ... when it comes to the concept of making new ... by various responsibilities ranging from taking care of one’s family ... comes with talking to a new person just is not ...
(Date:8/20/2014)... Ticketability.com has Theresa Caputo ... prices. The well-known medium has been thrilling many with ... in 19 cities, with tickets becoming available August 15. ... visit are Albany, Baltimore, Trenton, Erie, Buffalo, Philadelphia, Charlotte, ... and San Diego. The medium’s fans can obtain Theresa ...
(Date:8/20/2014)... Low market concentration, low price volatility, ... typify the market for packaging design services. These factors ... 5, indicating a moderate level of buyer power. “This ... an equal amount of leverage during negotiations,” according to ... substitutes exist for packaging design services . Buyers ...
Breaking Medicine News(10 mins):Health News:Ending Confusion About the Best Way to Brush Teeth 2Health News:Ending Confusion About the Best Way to Brush Teeth 3Health News:Hope For The Warriors Announces Got Heart, Give Hope Celebration in Washington, DC 2Health News:‘How to Make Friends as an Adult by Just Being Yourself: Becoming a “People Person” In Three Steps or Less’ Gives Tips for Making Friends During Adulthood - Vinamy 2Health News:Theresa Caputo Tour Tickets for Sale at Ticketability.com Cause a Buying Frenzy Among Customers Over Their Offering of Deeply Discounted Seats 2Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Packaging Design Services Procurement Category Market Research Report Now Available from IBISWorld 4
... by SharpBrains CEO on June 11th, during Games for Health Conference ... How can you take care of your brain when every ... to contradict each other? Do supplements improve memory? Do you need ... enough? Which brain training approach, if any, is worth your time ...
... York Hospital Queens One of Clinical Sites, Research Director is Co-Author ... world,s most respected medical journals, the New England Journal of ... treatments for people with both Type 2 diabetes and coronary artery ... Queens was one of the sites that conducted this study. ...
... (June 9, 2009) Carl D. Stevens, MD, MPH, ... Harbor-UCLA Medical Center (LA BioMed), recently received the Award ... Geffen School of Medicine at the University of California, ... dedication, innovation and sustained excellence in education." ...
... ANN ARBOR, Mich.---In places where young women outnumber young men, ... because the young men feel less pressure to settle down ... when those men reach their 30s, the reverse is true ... women outnumber men. Daniel Kruger, a University of ...
... meet criteria for full alert, agency says , TUESDAY, June ... swine flu in Australia may tip the balance and cause ... pandemic since 1968, agency officials said Tuesday. , Cases in ... occurring in the southern state of Victoria. Rapid spread of ...
... to a restful night, study finds , TUESDAY, June 9 ... trouble getting a good night,s sleep, you may want to ... that they slept better after trying meditation, according to a ... annual meeting of the Associated Professional Sleep Societies, in Seattle. ...
Cached Medicine News:Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 2Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 3Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 4Health News:First Brain Training Consumer's Guide Debunks Ten Brain Health Myths and Reviews 21 Products 5Health News:Landmark Study Published in New England Journal of Medicine 2Health News:Landmark Study Published in New England Journal of Medicine 3Health News:When young men are scarce, they're more likely to play the field than to propose 2Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 2Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 3Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 4Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 5Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 6Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 7Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 8Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 9Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 10Health News:WHO Declaration of Swine Flu Pandemic Looks Imminent 11Health News:Meditation May Help Put Primary Insomnia to Bed 2
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
Steroid-eluting, screw-in pacing lead...
Medicine Products: