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Clinical Study Shows Sustamine(TM) L-Alanyl-L-Glutamine Increases Performance in Endurance, Exercise and Activity
Date:2/11/2010

benefit that Sustamine™ has under these exercise and hydration stresses.  The role that this dipeptide has on the inflammatory, immune and recovery responses to these stresses was also examined.

Sustamine™ is the only GRAS (Generally Recognized As Safe) form of L-Alanyl-L-Glutamine for a variety of food, beverage and healthcare applications. It appears to increase electrolyte and fluid uptake across the intestines by increasing ion transport through an enhanced signaling pathway within the intestinal mucosal cells. Its implications for exercise are enhancement of fluid regulation during prolonged exercise in the heat, maintaining or enhancing performance during a hydration/heat stress, and enhancing recovery from exercise by modulating immune, inflammatory and oxidative stress responses to physical activity. 

Sustamine™, manufactured by Kyowa Hakko Bio Co. Ltd., is considered a "high-tech" amino acid dipeptide that promotes muscle rehydration, recovery and can be used as a source for energy refueling. Produced by a novel and cost effective patented fermentation technology, Sustamine™ L-Alanyl-L-Glutamine is available in powder form and is water-soluble into a clear solution. It is also odorless and tasteless.

Additional Sustamine™ highlights include:

  1. Patent pending for improved endurance performance
  2. Only stable form of glutamine for solutions or ready to drink beverages
  3. Stable in beverages with broad pH ranges
  4. Stable in beverages for over one year at room temperature

Dr. Hoffman's November 2009 SupplySide West seminar, Efficacy of Sustamine™ L-Alanyl-L-Glutamine Ingestion During Hydration Stress Under Intense Exercise is available for viewing at

SOURCE Kyowa Hakko
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