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Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint
Date:12/5/2007

n will die from the disease. Overall, the five- year survival rate for women with distant disease is estimated to be 29%. Although most patients initially respond to surgery and chemotherapy, the relapse rate is high and once relapse occurs, there is no known curative therapy.

About United Therapeutics

United Therapeutics is a biotechnology company focused on the development and commercialization of unique products for patients with chronic and life- threatening cardiovascular, cancer and infectious diseases.

Forward-looking Statements

Statements included in this press release that are not historical in nature are "forward-looking statements" within the meaning of the Private Securities Reform Act of 1995. Forward-looking statements include our expectation that full data from the trial will be presented at an upcoming medical meeting and will also be available in peer-reviewed journal articles, our intention to terminate the April 2002 license agreement with AltaRex Medical Corp., our intention to cease further development of the entire platform of antibodies, the prospects of triggering tumor-specific immunity using a murine monoclonal antibody, and our expectation relating to the amount of the write-down during the fourth quarter of 2007 relating to termination of the monoclonal antibody program. These forward-looking statements are subject to certain risks and uncertainties, such as those described in our periodic reports filed with the Securities and Exchange Commission, which could cause actual results to differ materially from anticipated results. Consequently, such forward-looking statements are qualified by the cautionary statements, cautionary language and risk factors set forth in our periodic reports and documents filed with the Securities and Exchange Commission, including our most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and current reports on Form 8-K. We claim the protection of the safe harbor cont
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