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Clinical Results Presented for Trovagene's Urine-Based High-Risk HPV Assay.
Date:8/25/2014

SEATTLE, Aug. 25, 2014 /PRNewswire/ -- Trovagene, Inc. (NASDAQ:   TROV), a developer of cell-free molecular diagnostics, announced today that results from two independent clinical studies were presented at the 29th International Papillomavirus (IPV) Conference. Results from both pilot studies consistently demonstrated that the Company's urine-based assay for the detection of high-risk HPV had high sensitivity (greater than 90%) for identifying women with high grade cervical intraepithelial neoplasia (CIN2/3). Assay performance was comparable to traditional HPV testing with commercially available tests in patient-matched cervical samples. In one of these studies, urine collection has been examined to establish standardization of urine as a clinical specimen for high-risk HPV testing.

In an oral presentation entitled "Evaluation of Two Urine-Based HPV Assays In Comparison to Cervical HPV Detection and High-Grade CIN Among Women Attending a Colposcopy Clinic," results from a population-based National Cancer Institute study, conducted at the University of Oklahoma Health Sciences Center, were released.  A total of 72 women with abnormal cervical cancer screening results were referred to a colposcopy clinic. Urine samples had been collected from each patient prior to undergoing a pelvic exam to obtain a cervical sample.  In urine samples, Trovagene's HR-HPV assay was superior to a commercially available HPV test for the identification of high-risk HPV positive women with CIN2/3.  When comparing patient-matched urine samples with cervical specimens for the identification of high-risk HPV positive women with CIN2/3, Trovagene's HR-HPV assay was comparable to traditional HPV testing from cervical specimens.

A second presentation entitled "A Comparison of Urine Collection Times for the Detection of High-Risk HPV Infection in Women" included results from a study conducted at University of North Carolina, Cha
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SOURCE Trovagene, Inc.
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