Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 AS...( INDIANAPOLIS May 19 /- Semafore Pharm...),Health

INDIANAPOLIS, May 19 /PRNewswire/ -- Semafore Pharmaceuticals, Inc., a privately held cancer drug discovery and development company, today announced that it will be reporting Phase I clinical data on its vascular targeted pan-PI3K/mTORC1/2 inhibitor, SF1126, during the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting, being held in Orlando, Florida, May 29 through June 2, 2009.

The presentation for Semafore's vascular targeted pan-PI3K/mTOR inhibitor is scheduled as follows:

    Time:        Saturday, May 30, 2009: 8:00 a.m. - 12:00 p.m. EDT
    Poster       Phase I evaluation of SF1126 a vascular targeted PI3K
    Title:       inhibitor administered twice weekly IV in patients with
                 refractory solid tumors
    Presenter:   Elena G. Chiorean, MD
    Location:    Level 2 - West Hall C. Poster Session Track: #79
                 Developmental Therapeutics: Cytotoxic Chemotherapy; Poster
                 Board B19 (Abstract # 2558)

About SF1126

SF1126 is the only clinical stage vascular targeted pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including mTORC1/2, DNA-PK, PLK-1, CK2, ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis and cell proliferation by targeting and binding to specific integrins that are expressed on the surface of new tumor vasculature and within the tumor compartment.

In preclinical xenograft models SF1126 has demonstrated broad activity as a single agent; synergy with commonly used chemotherapy agents, targeted agents, and radiation; and has been shown to reverse resistance mediated through the PI3K/PTEN pathway.

About PI3 Kinase

Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of intracellular signal transduction and are important in controlling cell growth/angiogenesis, d
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