Navigation Links
Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting
Date:5/19/2009

INDIANAPOLIS, May 19 /PRNewswire/ -- Semafore Pharmaceuticals, Inc., a privately held cancer drug discovery and development company, today announced that it will be reporting Phase I clinical data on its vascular targeted pan-PI3K/mTORC1/2 inhibitor, SF1126, during the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting, being held in Orlando, Florida, May 29 through June 2, 2009.

The presentation for Semafore's vascular targeted pan-PI3K/mTOR inhibitor is scheduled as follows:

    Time:        Saturday, May 30, 2009: 8:00 a.m. - 12:00 p.m. EDT
    Poster       Phase I evaluation of SF1126 a vascular targeted PI3K
    Title:       inhibitor administered twice weekly IV in patients with
                 refractory solid tumors
    Presenter:   Elena G. Chiorean, MD
    Location:    Level 2 - West Hall C. Poster Session Track: #79
                 Developmental Therapeutics: Cytotoxic Chemotherapy; Poster
                 Board B19 (Abstract # 2558)

About SF1126

SF1126 is the only clinical stage vascular targeted pan-PI3K inhibitor that selectively inhibits all PI3K class I isoforms and other key members of the PI3K superfamily, including mTORC1/2, DNA-PK, PLK-1, CK2, ATM and PIM-1. SF1126 is designed to inhibit both angiogenesis and cell proliferation by targeting and binding to specific integrins that are expressed on the surface of new tumor vasculature and within the tumor compartment.

In preclinical xenograft models SF1126 has demonstrated broad activity as a single agent; synergy with commonly used chemotherapy agents, targeted agents, and radiation; and has been shown to reverse resistance mediated through the PI3K/PTEN pathway.

About PI3 Kinase

Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of intracellular signal transduction and are important in controlling cell growth/angiogenesis, d
'/>"/>

SOURCE Semafore Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Unique Cardiovascular Treatment Readied for Global Market: Proprietary Paccocath(R) Technology is the Only Drug Eluting Balloon with Clinical Data
2. U.S. Naval Medical Research Center Proposed RESUS Clinical Trial in Trauma Patients Remains on FDA Hold
3. Novexel to Present Four Posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases in Helsinki
4. BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting
5. Novavax Completes Enrollment of Its Second Phase II Seasonal Influenza VLP Vaccine Clinical Trial
6. Pixantrone Phase 3 Data to be Presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting
7. Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009
8. TYRX Presents Early Clinical Results from AIGISRX(TM) Antibacterial Envelope Retrospective Registry
9. TargeGen Announces Successful Completion of Patient Enrollment in Clinical Trial of JAK2 Inhibitor TG101348 in Myelofibrosis Patients and Scheduled Presentation of Preliminary Trial Data at EHA Conference in Berlin
10. New MADIT II Clinical Data Analysis Shows Long-Term Survival Benefit for Implantable Defibrillator Therapy
11. Boston Scientific Data Show Real-World Survival Rates for Implantable Cardiac Device Patients Exceed Rates From Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 19, 2014  Advanced Medical Isotope Corporation ... engaged primarily in the development of brachytherapy devices ... today announced that a Life Sciences Discovery Fund ... for which AMIC is the commercialization partner.  The ... for the proposal titled "Optimized Injectable Radiogels for ...
(Date:12/19/2014)... N.C. , Dec. 19, 2014 ... optimize a product,s web presence to reflect the ... websites, in particular, must meet the needs of ... and culture. According to recent ... than half of the participating companies averaged more ...
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. ... (NASDAQ: SRNE ;  Sorrento), an oncology ... pain, and Conkwest, Inc., a privately-held immuno-oncology company ... Killer (NK) cell-line based therapy, announced today that ... to jointly develop next generation CAR-TNK™ (pronounced as ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Building a Best-in-Class Pharma Global Brand Website 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
(Date:12/22/2014)... Give a loved one the greatest gift ... and vitality. , For a limited time, HealthiPlus ( ... in special Holiday Wellness gift packages at drastically reduced ... bottle contains cutting-edge, proven nutritional support for joints, mental ... as we age. , Joint Health Plus ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 The MedTech industry ... Inc, a wholly owned subsidiary of PartnerTech AB of Sweden, ... having recently achieved additional ISO Certification. , All signs point ... employment and the likelihood of a repeal of the excise ... . The industry is anticipating annual growth of 9.3% and ...
(Date:12/22/2014)... Xarelto Lawsuit News : Alonso ... has granted a request to centralize pending and subsequent ... Eastern District of Louisiana. The U.S. Judicial Panel On ... to transfer over 50 Xarelto cases–21 lawsuits and 30 ... court for consolidation under U.S. District Judge Eldon E. ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 TheHardwareCity.com now ... glove with many useful features. Customers of the large ... have the new gloves delivered to their home or ... and hand tools that incorporate heavy duty magnets, which ... Glove allows workers to store metal parts on the ...
(Date:12/22/2014)... December 22, 2014 Christmas is days away, ... a fast and easy solution that will please: the ... be purchased from from $25 up to $350," says Kathy ... customer satisfaction and a wide array of skin care products ... and no expiration dates. , Gift delivery past shipping ...
Breaking Medicine News(10 mins):Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:PartnerTech Inc. Poised for Growth in MedTech 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2
... time could be counterproductive, researchers say , THURSDAY, Oct. 15 ... and essential part of building an immune response, and ... Tylenol -- after a shot could dampen that response, a ... that a child,s immune system is processing the immunization, providing ...
... Oct. 16 Mars Snackfood US announced today that Kyle Busch, ... Cup Series, plans to go pink this weekend during the NASCAR ... to support Susan G. Komen for the Cure®. Busch plans ... the wheel of an all pink M&M,S car during the Saturday ...
... , FORT WORTH, Texas, Oct. 16 Wound Management ... provider of specialty medical products, announced today that its subsidiary ... 24th Annual Clinical Symposium on Advances in Skin & ... opens on October 22 in San Antonio. , Dr. ...
... ... business, Dr. Philip Straka, a plastic surgeon in Houston , says he’s actually seeing ... ... be hitting a large number of economic sectors, but one area plastic surgeon says its ...
... ... of their "Tats for Tatas" fundraising campaign that will take place throughout ... company,s concerted efforts to raise awareness and funds for Breast Cancer Awareness, ... company will be donating 10% of all proceeds from sales throughout the ...
... to Feature Gena Rowlands , EAST BRUNSWICK, N.J., Oct. 15 ... return home to New Jersey to host a celebrity cocktail ... reception will raise money for National MS Society,s New Jersey ... New Jersey, where it is estimated that almost 10,000 people ...
Cached Medicine News:Health News:Tylenol May Weaken Effectiveness of Kids' Vaccines 2Health News:Mars Lends Sweet Support in Fight Against Breast Cancer Through Its M&M's(R) And Dove(R) Chocolate Brands, as Well as Its Celebrated Race Team 2Health News:Mars Lends Sweet Support in Fight Against Breast Cancer Through Its M&M's(R) And Dove(R) Chocolate Brands, as Well as Its Celebrated Race Team 3Health News:Wound Management Technologies Announces Clinical Study Presentation of CellerateRx(R) Technology at Leading Skin and Wound Care Conference 2Health News:Wound Management Technologies Announces Clinical Study Presentation of CellerateRx(R) Technology at Leading Skin and Wound Care Conference 3Health News:Houston Plastic Surgeon Seeing Growth in Aesthetic Enhancement Procedures Despite Rough Economy 2Health News:Houston Plastic Surgeon Seeing Growth in Aesthetic Enhancement Procedures Despite Rough Economy 3Health News:Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research 2Health News:East Brunswick Native Returns Home to Help New Jersey Residents Living with MS 2
... high-power, long-pulse Nd:YAG technology provides practitioners with the ... lesions and perform permanent hair reduction on all ... size feature allows the practitioner to instantly switch ... spot size with a simple twist of the ...
...
...
... is your system. CONMED's family of products ... New, state-of-the art generators feature proprietary Energy ... continuous synchronization of current and voltage in ... enables the system to sample current and ...
Medicine Products: