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Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab
Date:8/14/2008

First T cell engaging antibody (BiTE) showing clinical benefit in cancer patients; Blinatumomab enables patients own T cells to recognize and attack

cancer cells

BETHESDA, Md., Aug. 14 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced publication of a Phase 1 clinical study(1) on its BiTE(R) antibody blinatumomab (MT103/MEDI-538) in this week's issue of Science. The article is available at http://www.sciencemag.org. Blinatumomab is being co-developed with MedImmune.

Blinatumomab is a novel antibody therapy that activates a patient's T cells to seek out and destroy cancer cells. The phase 1 study demonstrated tumor regression, and in some cases, complete remission, in non-Hodgkin's lymphoma patients who relapsed after previous treatments and were considered to have incurable disease. Most of the remissions are reported to continue, with the longest remission ongoing for more than one year. Results from this ongoing Phase 1 clinical trial with the CD19-specific BiTE antibody blinatumomab show that all seven patients treated to date at 0.06 mg/m2 per day achieved complete or partial responses. The safety profile observed in this study supports continued blinatumomab development.

"These results represent significant progress of a T cell engaging antibody for treatment of lymphoma patients as single agent therapy. We observed tumor regression in patients at serum levels of blinatumomab, which are approximately five orders of magnitude lower than serum levels needed by conventional m
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SOURCE Micromet, Inc.
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