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Clinical Data Presented at Asia PCR/Sing LIVE Demonstrate Benefits of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) in Challenging Patient Subsets
Date:1/23/2010

ith non-ST-segment elevation acute coronary syndrome (NSTE-ACS). The randomized study with 60 patients compared the Genous Bio-engineered R stent with bare metal stents with concomitant high dose atorvastatin in the reduction of neointimal hyperplasia assessed by coronary angiography and IVUS after six months.

In the JACK-EPC trial, the Genous Bio-engineered R stent induced less neointimal hyperplasia and a lower binary restenosis rate of 13 percent in the Genous Bio-engineered R stent, compared to 26.6 percent in the control group. Importantly, the major adverse cardiac events (MACE) rate was reported at only 10 percent in the Genous Bio-engineered R stent treated patient group versus 16 percent in the bare metal stent treated group.

"In our small study, we observed a lower amount of neointimal proliferation with the EPC capture stent compared to the bare metal stent control," said Wojakowski.  "Good safety is indicated by comparable stent thrombosis.  We think this makes the Genous stent a very promising treatment strategy for ACS patients, especially those with high risk of bleeding or not eligible for prolonged dual antiplatelet therapy due to allergy to ASA or clopidogrel."

"Data from both presentations support the use of the Genous Bio-engineered R stent as an effective treatment option in what interventional cardiologists find to be challenging cases," said Al Novak, OrbusNeich's chairman and CEO. "We look forward to continuing to work with physicians to realize the full potential of the Genous technology."

About Genous  

Genous is OrbusNeich's patented endothelial progenitor cell (EPC) capture technology that promotes the accelerated natural healing of the vessel wall after the implantation of blood-contact devices such as stents. The technology consists of an antibody surface coating that attracts EPCs circulating in the blood to the device
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