Navigation Links
Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study
Date:10/11/2007

to analyze dose response.

In the first step of the statistical analysis, the high-dose teduglutide group was compared with the placebo group using a 0.05 significance level. If the high-dose group was not statistically significantly different from the placebo group, no further comparisons would be made. If the high-dose group showed statistical significance, comparisons were to continue to a second analysis step, where the low dose was to be compared with the placebo.

Phase 2 Proof-of-Concept Study Results

In the Phase 2 GATTEX proof-of-concept study, the drug was given by subcutaneous injection for 21 days to 16 patients with SBS. Three patients received 0.03 mg/kg/day, ten patients received 0.10 mg/kg/day, and three patients received 0.15 mg/kg/day. Results of the Phase 2 study indicated that GATTEX was safe and well-tolerated, resulted in intestinal epithelial regeneration and significantly increased intestinal absorption and body weight in parenteral-nutrition-dependent SBS patients.

About SBS

SBS is a condition resulting from the surgical removal of significant portions of the bowel following injury or illness. There are 16,000 to 20,000 adult patients with SBS in the United States. Regulatory authorities in the U.S. and European Union have granted orphan drug status to teduglutide for its potential use, if approved, in treating SBS. Symptoms of SBS include diarrhea, dehydration, malnourishment, and weight loss caused by an inadequate absorption of nutrients and fluids from the diet. Long-term complications of the condition may include an increased risk of systemic infections due to the presence of an intravenous feeding line, degenerative changes in the bones and nerves due to vitamin and mineral deficiencies, and liver failure. Potential benefits derived from reduced dependence on intravenous feeding may include improved nutrition, lower rates of infections, and improved quality of life due to more time away from intravenous feed
'/>"/>

SOURCE NPS Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Sygnis Pharma AG announces date for presentation of clinical results
5. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
6. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
7. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
8. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
9. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Protox Announces Positive Clinical Data from Prostate Cancer Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... 2013 iHealth Lab Inc., a pioneer ... healthcare products and a powerful integrated mobile app ... of two new fitness products to its existing ... the Wireless Pulse Oximeter and Wireless Activity and ... iHealth Lab is also excited ...
(Date:5/21/2013)... , May 21, 2013  Lehigh Valley Health Network ... TM devices, adding to its existing arsenal of ... taking up residence within the network, LVHN is now ... to proactively combat superbugs and provide the best possible ... Room Ultraviolet Disinfector, TRU-D – the signature product of ...
(Date:5/21/2013)... 21, 2013  Healthcare organizations expanding into emerging markets ... , India and ... no shortcuts.  This is proving particularly challenging, considering the ... must change the dialogue around BRIC, as it is ... and building regional partnerships to build a sustainable business. ...
Breaking Medicine Technology:iHealth Lab adds new products and partners to mobile personal healthcare offering 2iHealth Lab adds new products and partners to mobile personal healthcare offering 3Lehigh Valley Expands Fleet of Superbug-Slaying Robots 2Lehigh Valley Expands Fleet of Superbug-Slaying Robots 3Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets 2Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets 3Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets 4
... Va., Aug. 30, 2011 Star Scientific, Inc. (NASDAQ: ... is pleased to initiate the launch today of Anatabloc™, ... immune system in maintaining healthy levels of inflammation.  Anatabloc™, ... being launched via a dedicated website ( www.anatabloc.com ) ...
... 2011 Bench International, a global, milestone-based, performance-driven ... sciences industry, recently opened new offices in Geneva ... strategy. The offices are strategically placed to serve ... aligned with Bench,s European headquarters in London to ...
Cached Medicine Technology:Star Scientific Launches Anatabloc™ Dietary Supplement 2Star Scientific Launches Anatabloc™ Dietary Supplement 3Star Scientific Launches Anatabloc™ Dietary Supplement 4Star Scientific Launches Anatabloc™ Dietary Supplement 5Bench International Expands Presence in Europe with Opening of Offices in Switzerland 2
(Date:5/21/2013)... 21, 2013 Representatives with Hammerhead Bicycles announced ... success that the company has achieved its overall goal of ... one was to move Hammerhead Bicycles from a house brand ... Scott Robertson. , Robertson explained that the bike shop will ... exclusively focus on all things 29er and 650b. ...
(Date:5/21/2013)... MAY 21, 2013 Three major Ohio universities and ... Foundation to establish a new collaborative research program aimed ... The March of Dimes intends to invest $10 million ... March of Dimes Prematurity Research Center -- Ohio Collaborative ... Howse, President of the March of Dimes. "This new ...
(Date:5/21/2013)... Atlanta, GA (PRWEB) May 21, 2013 ... Care, ScripNet and Procura Management, today announced that ... Award at Catamaran’s client advisory meeting. Conferred ... has partnered with Catamaran to create cutting edge ... This year, Healthcare Solutions was recognized for its ...
(Date:5/21/2013)... 2013 A plastic surgery Internet ... plastic surgery SEO services following an Internet survey. ... name the “Best Plastic Surgery SEO Services”. , ... was predictable. Well-known in the plastic surgery Internet ... than any other selection based on superior client ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Nearly 40 ... out of an award trip in Los Cabos, Mexico, Feb. ... “day house” for the elderly. , The facility serves meals ... of San Jose del Cabo, Mexico. , Platinum Vice President, ... while reflecting on the company’s history. , “Platinum got its ...
Breaking Medicine News(10 mins):Health News:Hammerhead Bicycles Now a Standalone Brand 2Health News:New multi-million dollar research center aims to solve the mystery of premature birth 2Health News:New multi-million dollar research center aims to solve the mystery of premature birth 3Health News:Healthcare Solutions Receives Innovation Award From Catamaran 2Health News:JD Media Surge's CosmeticSurgeonsOnline.com Voted #1 Source for Plastic Surgery SEO 2Health News:Platinum Supplemental Insurance Gives Back at Casa De Dia, Mexico 2Health News:Platinum Supplemental Insurance Gives Back at Casa De Dia, Mexico 3
... preventable, treatable diseases around,the world, Statement by ... TOYAKO, Japan, July 8 "The worldwide,pharmaceutical ... and,the Drugs for Neglected Diseases initiative (DNDi) in ... neglected diseases as a global health threat,and a ...
... 8 An economist examining the,proposed merger of ... the combined companies would have a market share ... to testimony presented to the,Pennsylvania Insurance Department today ... of CRA International, the proposed merger,would result in ...
... disorder is one of the most complex and challenging ... associated with considerable acute and longterm treatment needs and ... times of tremendous social burden for both the individual ... episodic, yet lifelong and clinically severe mood disorder. The ...
... tendon rupture, agency says , , TUESDAY, July 8 (HealthDay ... carry a black box warning alerting physicians to the ... their use, the U.S. Food and Drug Administration said ... 60; in kidney, heart and lung transplant recipients; and ...
... At 12:00 noon on July 8, 2008, J.,Douglas ... P.C.,filed the first drug product liability action in ... former Governor Engler,s grant of immunity,to drug manufacturers., ... was filed in the United,States District Court, Eastern ...
... the most important single factor predisposing to suicide, ... suicide are known to have suffered from depression. ... even after a suicide attempt. Antidepressive drugs represent ... their role has become somewhat controversial over the ...
Cached Medicine News:Health News:Global Health Progress Joins WHO and DNDi to Call For Increased Commitments to Fighting Neglected Tropical Diseases 2Health News:Economist Finds Highmark/IBC Merger Would Result in 70 Percent Share in Pennsylvania, Far Higher Than Initial Reports 2Health News:The ECNP consensus statement on bipolar depression 2Health News:FDA Mandates Black Box Warning for Some Antibiotics 2Health News:National Class Action Filed Against Manufacturer of Digitek(R) (Prescription Drug) in Federal Court in Michigan 2
... blade. 17 mm wide blade. ... inches. Note: Has Marcks attachment ... to any thickness up to ... thicker grafts or split graft. ...
9 mm button end blade. 15 mm long backcutting blade. Angled at 45 degrees. Flat handle. Designated most popular model or size....
4 mm blade. Bayonet. Flat handle....
5 mm blade with slightly rounded tip. Round handle....
Medicine Products: