Navigation Links
Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study
Date:10/11/2007

nue our current exploration of GATTEX in other indications with high unmet needs, including chemotherapy-induced GI mucositis and necrotizing enterocolitis."

There are several hypotheses that may explain the higher response in the low-dose group versus the higher-dose group. One theory is that, at higher doses, GLP-2 suppresses appetite and it is possible that patients on the higher dose consumed fewer calories from food and thus did not decrease their PN regimens. A second hypothesis is that GLP-2 exerts various dose-dependent effects and may act by increasing nutrient absorption at low-doses while higher doses of GLP-2 may have a greater effect on mucosal and epithelial regeneration.

Dr. Daniel Drucker, director, Banting and Best Diabetes Centre at the University of Toronto and the scientist who discovered the role of GLP-2, commented, "Recently published animal studies demonstrate that lower doses of GLP-2 can enhance nutrient absorption through enhancement of mechanisms promoting nutrient transport across the gut epithelium and via improved intestinal cell survival, while higher doses of GLP-2 can result in mucosal regeneration. These observations suggest that lower doses of GATTEX may have the greatest potential for effectively treating short bowel syndrome by improving nutrient absorption, while higher doses of GATTEX may have the greatest potential for effectively treating other gastrointestinal disorders where mucosal regeneration may be more important."

Study Design and Top-Line Results

This multicenter, double-blind, international Phase 3 trial was designed to evaluate the efficacy, safety, tolerability and pharmacokinetics of GATTEX compared with placebo in patients with parenteral nutrition (PN)-dependent short bowel syndrome. Eighty three (83) patients who were enrolled in the trial were randomly assigned to receive daily subcutaneous injections of 0.05 milligrams or 0.10 milligrams of GATTEX per kilogram of body weight or a plac
'/>"/>

SOURCE NPS Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Genetic Analysis Systems Enter the Clinical Mainstream
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Large Geographic Differences in EpiPen Prescriptions in the U.S., From the Journal of Allergy and Clinical Immunology
4. Sygnis Pharma AG announces date for presentation of clinical results
5. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
6. Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent
7. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
8. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
9. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Protox Announces Positive Clinical Data from Prostate Cancer Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , Chine, 3 juillet 2015 BGI ... à haut débit de l,ADN situé à ... certification de  l,American College of Pathologists  (Collège des ... à Hong Kong constituent ... génération à recevoir la certification du CAP en ...
(Date:7/2/2015)... FORT LAUDERDALE, Fla. , July 2, 2015 ... & Co., is pleased to announce that its ... Inc. ("Insight Beverages") to Kerry Group plc (ISE: ... focused on taste and nutrition systems, as well ... food, beverage and pharmaceutical markets. Farlie Turner served ...
(Date:7/2/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/n7kzjb/vitamin_d_market ... Market by Analog, Application, End-User & by Region - Global ... This market is projected to reach about $2.5 ... different applications and rising opportunities in countries such as ... Italy , and Brazil . ...
Breaking Medicine Technology:BGI obtient la certification du Collège des pathologistes américains (CAP) 2Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 3
(Date:7/2/2015)... VA (PRWEB) , ... July 02, 2015 , ... ... Congresswoman Donna Edwards (D-Md.) for her introduction of the Stop Overdose Stat (S.O.S.) ... introduced by Senator Jack Reed (D-R.I.), this Act seeks to decrease drug overdose ...
(Date:7/2/2015)... ... July 02, 2015 , ... In 2012, Patrick Achebe realized that the gift of poetry ... sat down to write his first poem, and three years later he was publishing an ... and worth sharing with the world. "I have always believed that the best way to ...
(Date:7/2/2015)... CITY, GA (PRWEB) , ... July 02, 2015 , ... ... their newest innovation in compression socks designed for men. , For style that’s ... socks into their daily routine. This is great news for men everywhere because a ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... and Emerging Healthcare Delivery Coalition met for the late June Web-based session, the ... with new reimbursement schemes and managing high-risk patients through coordinated care. , During ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... and executing them with care and precision. There is an art and science ... had the honor of successfully reshaping the facial features and lives of more ...
Breaking Medicine News(10 mins):Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3Health News:Patrick Achebe Releases Debut Book, Whispering Waves: Poems for Everyday Grace 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 2Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 4Health News:Dr. Kevin Sadati Featured in July Issue of Popular National Magazines 2Health News:Dr. Kevin Sadati Featured in July Issue of Popular National Magazines 3
... MONDAY, March 7 (HealthDay News) -- Genetics may predispose some ... and stress are a fact of daily life -- to ... warns. The culprit is a specific abnormality of the ... gene is known to play a key role in the ...
... March 7, 2011 Embargoed by the journal ... time Working as part of a public program to ... useful molecules, scientists from The Scripps Research Institute and ... potent class of potential anti-cancer and anti-neurodegenerative disorder compounds. ...
... it won,t be obvious to UCSF Medical Center patients, behind ... processes their medications. With a new automated hospital pharmacy, believed ... technology and electronics to prepare and track medications with the ... error has occurred in the 350,000 doses of medication prepared ...
... of recognizing tumor growth, and naturally mounts an anti-cancer ... (antigens) and present them to T cells, and those ... kill tumor cells. In recent years, researchers have attempted ... new therapies- namely, by generating a pool of tumor ...
... Transplanting stem cells derived from umbilical ... offer future therapeutic benefit for those suffering from ... says a team of neuroscience researchers from the ... Brain Repair and collaborators from three private-sector research ...
... Reinberg HealthDay Reporter , SUNDAY, March 6 (HealthDay ... a safe way to detect Down syndrome during pregnancy, researchers ... identified a gene mutation associated with Down syndrome with 100 ... is a common birth defect, with one Down syndrome birth ...
Cached Medicine News:Health News:Mix of Genetics and Stress Can Impair Mental Abilities 2Health News:Scripps Research and MIT scientists discover class of potent anti-cancer compounds 2Health News:Scripps Research and MIT scientists discover class of potent anti-cancer compounds 3Health News:Scripps Research and MIT scientists discover class of potent anti-cancer compounds 4Health News:New UCSF robotic pharmacy aims to improve patient safety 2Health News:New UCSF robotic pharmacy aims to improve patient safety 3Health News:Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders 2Health News:Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders 3Health News:Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders 4Health News:Noninvasive Test May Identify Down Syndrome Early On 2
... Tissue Oximeter is a lightweight, portable console display ... with two separate channels for up to one ... well as adjustable alarms for low and high ... very user friendly and requires minimal training., ,Sensors ...
CO 2 SMO-Capnograph/Pulse Oximeter...
... the next generation in pulse oximetry monitoring ... current family of "digital pulse oximeters, MARSpO ... breakthroughs in signal processing. This provides improved ... superior performance during challenging clinical conditions such ...
... Pulse Oximeter is a one-of-a-kind oximeter that ... the N-20PA has been shock-tested, vibration-tested and ... it has even withstood the rigors of ... spot check measurements and also useful for ...
Medicine Products: