Navigation Links
Cleveland Clinic to Lead First Head-to-Head Comparison of the Two Most Potent Statins
Date:1/15/2008

Study Designed to Determine Statin Effects on Regression of Atherosclerosis

CLEVELAND, Jan. 15 /PRNewswire/ -- Cleveland Clinic researchers will coordinate the first head-to-head comparison of the two most powerful statin medications. The trial intends to begin enrollment as early as next week. Statins are the world's most commonly prescribed drugs and widely used to treat patients with elevated cholesterol levels.

The two drugs, atorvastatin (Lipitor) and rosuvastatin (Crestor), lower LDL ("bad") cholesterol and raise HDL ("good") cholesterol. But which drug is best for patients with heart disease? This study will seek to answer this important scientific question by measuring the rate of regression of coronary disease using intravascular ultrasound (IVUS), a technique that directly measures the amount of plaque in the coronary arteries.

The SATURN study (Study of Coronary Atheroma by InTravascular Ultrasound: Effect of Rosuvastatin Versus AtorvastatiN) will compare the ability of these two statins to stop the progression of atherosclerosis, the main cause of cardiovascular disease, over a two year treatment period.

SATURN, a multicenter, double-blind Phase IIIb trial, will use IVUS imaging to study approximately 1,300 patients at 150 hospitals in 20 countries worldwide. The trial is expected to be completed in 2011. Cleveland Clinic cardiologist Stephen J. Nicholls, M.D., PhD., will lead the trial.

Cleveland Clinic researchers have conducted two previous studies with IVUS looking at statins and the rate of atherosclerosis regression. Researchers have found a significant benefit with statins by intensively lowering LDL- cholesterol and the inflammatory marker C-reactive protein (CRP) and by raising levels of HDL cholesterol. SATURN aims to determine if differences in the ability of the different statins to lower LDL and raise HDL can promote regression (reduction in the amount of plaque in the coronary arteries).

About Cleveland Clinic

Cleveland Clinic, located in Cleveland, Ohio, is a not-for-profit multispecialty academic medical center that integrates clinical and hospital care with research and education. Cleveland Clinic was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. U.S. News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. Approximately 1,800 full-time salaried physicians and researchers at Cleveland Clinic and Cleveland Clinic Florida represent more than 100 medical specialties and subspecialties. In 2006, there were 3.1 million outpatient visits to Cleveland Clinic. Patients came for treatment from every state and from more than 80 countries. There were more than 53,000 hospital admissions to Cleveland Clinic in 2006. Cleveland Clinic's Web site address is http://www.clevelandclinic.org .


'/>"/>
SOURCE Cleveland Clinic
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Researchers at Cleveland Clinic Identify Site of Dysfunction in HDL, Carrier of Good Cholesterol
2. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
3. CellCyte Genetics Corp. Enters Collaborative Research Agreement With Cleveland Clinic Foundation to Qualify Stem Cell Delivery in Damaged Heart Tissue
4. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
5. Cleveland Clinic Summits to Focus on Cardiovascular Medical Innovation
6. The Leukemia & Lymphoma Society and Cleveland Clinic Taussig Cancer Institute Announce Groundbreaking Partnership to Accelerate Drug Approvals
7. Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection
8. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
9. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
10. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
11. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... 2016 --> ... Inflammation Global Clinical Trials Review, H2, 2015 provides ... clinical trials landscape along with top level data ... (G7 & E7), Trial Status, Trial Phase, Sponsor ... companies involved and enlists all trials (Trial title, ...
(Date:2/11/2016)... The primary goal of this research is to analyze ... of liquid biopsy. Key information the survey seeks to ... liquid biopsy adoption amidst future users - Predominantly used ... Sample inflow to conduct liquid biopsy tests - Preference ... on. - Correlation analysis of sample type and biomarker ...
(Date:2/11/2016)... PRO-DEX, INC. (NasdaqCM: PDEX) today announced financial results ... The Company also filed its Quarterly Report on Form 10-Q ... Securities and Exchange Commission today. --> ... --> --> Net sales for the ... 95%, to $5.4 million from $2.8 million for the three ...
Breaking Medicine Technology:
(Date:2/12/2016)... Highlands Ranch, Colo. (PRWEB) , ... February 12, 2016 , ... ... particularly over the past 35 years. A president has access to health and wellness ... leader of the free world, no single individual has a schedule as frenetic as ...
(Date:2/12/2016)... ... ... The Central Coast Autism Spectrum Center (CCASC) invites teens ages 11-18 to its annual Winter ... teens with and without special needs to gather in a safe and supportive environment. Volunteers ... will take place on Saturday, Feb. 13 from 7 to 9:30 p.m. at Elks Lodge, ...
(Date:2/12/2016)... ... 12, 2016 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... he says are the real facts surrounding all those Bible stories. For generations families ... school teachers, and Yisrayl says there is more to these than just mere “stories”. ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Planet ... Studios. The new cartoon style themes are great for showcasing pictures, videos as well ... scene generators, titles like introductions, lower thirds, transitions and a beautiful frame overlay. Pixel ...
(Date:2/12/2016)... ... February 12, 2016 , ... Dignity Health named Dr. Scott Bingham the ... The new facility is licensed under Dignity Health Arizona General Hospital , ... excellent leader and will ensure our new freestanding emergency room delivers the highest quality ...
Breaking Medicine News(10 mins):