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Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
Date:9/11/2007

ch, the drug's manufacturer, Takeda of Lincolnshire, Ill., transferred a database containing individual patient data collected during clinical trials of pioglitazone to Cleveland Clinic's Cardiovascular Coordinating Center for independent analysis. Although funding was provided, the company played no role in conducting the analysis. All the studies were randomized, double-blinded, and controlled with placebo or active comparator. The period of time in which patients received treatment ranged from four months to 3.5 years.

In addition to Dr. Lincoff, researchers involved in the study included Stephen J. Nicholls, M.B.B.S., Ph.D., a Cleveland Clinic cardiologist; Steven Nissen, M.D., Chairman of the Department of Cardiovascular Medicine at Cleveland Clinic; and Cleveland Clinic statistician, Kathy Wolski.

The study of pioglitazone follows a meta-analysis Dr. Nissen and Ms. Wolski conducted earlier this year on the use of rosiglitazone (Avandia(TM)), another commonly used diabetes drug. In his analysis of 42 clinical trials, Dr. Nissen found that rosiglitazone raised patients' risk of heart attack and cardiovascular death by 43% and 64%, respectively in comparison to the use of a placebo or other anti-diabetes therapy.

Cleveland Clinic, located in Cleveland, Ohio, is a not-for-profit multispecialty academic medical center that integrates clinical and hospital care with research and education. Cleveland Clinic was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. U.S. News & World Report consistently names Cleveland Clinic as one of the nation's best hospitals in its annual "America's Best Hospitals" survey. Approximately 1,800 full-time salaried physicians and researchers at Cleveland Clinic and Cleveland Clinic Florida represent more than 100 medical specialties and subspecialties. In 2006, there were 3.1 million outpatient visits to Cle
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