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Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
Date:8/27/2007

blood. The researchers demonstrated that platelets from humans lacking CD36, a rare genetic disorder, have altered platelet responsiveness. They further demonstrated that the genetic deletion of CD36 could protect mice fed a high fat diet from developing hyperreactive platelets. Prior studies by Maria Febbraio, Ph.D., and Roy Silverstein, M.D., researchers in the Lerner Research Institute's Department of Cell Biology, and Co-Investigators on the study, showed genetic deletion of CD36 protects mice from atherosclerosis, the accumulation of plaque in blood vessels.

In addition to Drs. Febbraio, Hazen, Podrez and Silverstein, the research team also comprised Tatiana Byzova, Ph.D., and Renliang Zhang, M.D., Ph.D., of Lerner Research Institute and Robert Salomon, Ph.D., of Case Western Reserve University.

The researchers' findings appear in "Platelet CD36 Links Hyperlipidemia, Oxidant Stress and Prothrombotic Phenotype," a paper published online on Aug. 26 in the journal Nature Medicine.

About Cleveland Clinic's Lerner Research Institute

The Lerner Research Institute is home to Cleveland Clinic's laboratory- based and translational biomedical research. Its mission is to understand the causes of human diseases and to develop new treatments and cures. The Lerner Research Institute's total annual research expenditures exceed $120 million from Federal agencies, non-Federal societies and associations, endowment funds and the Cleveland Clinic. More than 1,100 people (including about 160 investigators, 350 junior faculty and postdoctoral fellows, and 120 graduate students) work in research programs focusing on cardiovascular, cancer, neurologic, musculoskeletal, allergic and immunologic, eye, metabolic, and infectious disease. The Institute also is an integral part of the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University -- training the next generation of physician-scientists.

About Cleveland Clinic

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