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Cleveland Clinic Leading Clinical Program to Improve Early-Stage Lung Cancer Detection
Date:11/26/2007

and University Hospitals Health System, have joined together to form the Early Lung Disease Detection Alliance (ELDDA), a multidisciplinary research and commercialization program that will develop, test (through clinical trials), and bring to market new image-analysis systems that permit the early detection of lung cancer and other lung diseases. This computer-aided detection (CAD) system will be applied to the most widely available and used imaging exam, the chest x-ray. The goal is to not only advance the early detection of lung cancer and other diseases but also accelerate the commercialization of computer-aided detection, image interpretation, and multidisciplinary applications of computer science and medical diagnostics.

The current retrospective study is a multiple-reader multiple-cases study involving six expert chest radiologists, six general radiologists, and six pulmonologists to assess the usefulness of CAD. Each reader will read 200 cases of suspected lung cancer of which about 100 had cancer and 100 did not. All cases were CT confirmed. All cancers are biopsy or surgically confirmed.

The study is expected to be completed by the end of the year. Investigators from Cleveland Clinic include Dr. Phillips, Moulay Meziane, M.D., Section Head of Chest Imaging, Peter Mazzone, M.D., Staff Pulmonary Medicine and Nancy Obuchowski, Ph.D., Vice Chair, Department of Quantitative Health Services.

Previous Studies Establish Value of OnGuard(TM) Chest X-Ray CAD

-- Fifteen community-based board-certified radiologists read chest X-ray

images without and with chest X-ray CAD. Forty-two percent and 22

percent of nodules sized 9-14 mm and 20-27 mm, respectively, were

missed. Ten of the 15 radiologists improved their detection rate

using chest X-ray CAD; they benefited in detecting Stage I cancers of

all sizes between 9 and 30 mm (10 percent improvement) and benefited

most
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SOURCE Cleveland Clinic and Riverain Medical
Copyright©2007 PR Newswire.
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