Navigation Links
Circassia Achieves Successful Phase II Clinical Results With Toleromune(R) Anti-Allergy Technology
Date:9/10/2008

OXFORD, England, September 10 /PRNewswire/ -- Circassia Ltd, a specialty biopharmaceutical company focused on controlling immune system responses, today announced positive results from a phase II clinical study of its anti-allergy technology, ToleroMune(R), in the field of cat allergy. The trial showed that ToleroMune treatment can substantially reduce allergic reactions to the allergen that causes most cat allergies, and importantly was well tolerated by all patients.

Circassia conducted the double-blind study in Germany, where patients with a confirmed history of cat allergies received a single dose of ToleroMune therapy or placebo. The 88 study participants were divided into groups, with each receiving a different dose, either via subcutaneous or intradermal injection to compare the two routes of administration. To test the effect of the treatment, patients received a microscopic dose of cat dander (the main allergen responsible for cat allergies) into their skin several weeks later. Patients who received ToleroMune therapy via the most effective administration route had markedly reduced skin reactions to the cat allergen at all of the five dose levels tested compared with placebo. The most effective dose reduced reactions by over 40%, compared with 10% for placebo. Throughout the study the ToleroMune treatment proved well tolerated, with no serious or severe adverse events experienced in any of the groups, despite the steadily increasing doses.

"These results are extremely encouraging, both for Circassia and the huge number of people who suffer from allergies. Current treatment options address the symptoms only or require repeated administrations over many months under specialist supervision because of the potential for serious and even life-threatening side effects, which is a particularly important issue for cat allergy therapies. Therefore, achieving a marked reduction in allergic responses after just a single dose is remarkable, and we aim to build on this by testing short treatments of several doses in future trials," said Steve Harris, Circassia's CEO. "Our goal for ToleroMune is to provide a range of allergy therapies that effectively and quickly treat the underlying disease while also offering excellent safety. Consequently, these positive clinical results will not only contribute to the development of our cat allergy product, but will also provide the foundations for our other allergy programmes that utilize our ToleroMune technology."

In addition to their potential clinical benefits, Circassia's anti-allergy products would have significant market opportunities. Currently, over 150 million people suffer from allergic rhinitis in the US and Europe and the market for current treatments, despite their limitations, is approximately $12 billion per year. The prevalence of cat-dander allergy is high, with 1-in-6 Americans and nearly 10% of Europeans suffering from the condition. Existing treatments have a number of issues, either providing symptomatic relief only or requiring lengthy supervision by specialist physicians. In contrast, Circassia's ToleroMune technology has the potential to rapidly desensitize sufferers using extremely small sections of allergens (termed T-cell epitopes), which minimizes the potential for adverse reactions.

About Circassia

Circassia is a specialty biopharmaceutical company focused on developing medicines designed to control immune system responses. The company has a highly experienced management team with a proven track record in product development and commercialization, and having successfully completed two fundraising rounds is backed by a syndicate of world-class venture capital and institutional investors, including Imperial Innovations, Lansdowne Partners, Goldman Sachs and Invesco Perpetual.

Circassia's lead products target allergies utilizing the company's proprietary T-cell epitope desensitization technology, ToleroMune. The company is also developing its ToleroTrans organ anti-rejection technology, which uses a similar approach to down-regulate immune responses in transplant patients.

For more information please visit http://www.circassia.co.uk.


'/>"/>
SOURCE Circassia Ltd
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Agile Therapeutics Achieves Phase 2 Study Endpoints in Key Clinical Trials with New, Innovative Low-Dose Contraceptive Patch
2. Intermezzo(R) 3.5 mg Achieves Greater Early Bioavailability Than Ambien(R) 10 mg Despite 65% Lower Dose
3. TriMix Gel Achieves Success Among Men Who Have Failed to Achieve Erections With Viagra, Levitra and Cialis Type Tablets
4. Prescient Medical, Inc. Achieves Successful Clinical Debut of vProtect(TM) Luminal Shield
5. Pharmacopeias First-in-Class Investigational Therapy PS433540 Achieves Statistically Significant Reductions in Blood Pressure in Hypertensive Patients
6. CureDMs Diabetes Therapy Achieves Major Development Milestone
7. EntreMed Achieves a Key Milestone Through Initiation of ENMD-2076 Clinical Program
8. Bionomics Achieves US$1 Million Milestone Payment from Genmab
9. Lotus Pharmaceuticals, Inc. Achieves Significant Milestones in the Development of Isosorbide Mononitrate Sustained Release Tablets
10. Tolerx Achieves Milestone with Completion of Phase Ib Clinical Study of TRX1 in Cutaneous Lupus Erythematosus
11. Surface Logix Achieves Objectives With SLx-2101 in Phase 2a Clinical Trial in Hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Actinic Keratosis Market and ... their offering.       (Logo: ... Market and Competitive Landscape Highlights 2016, provides ... Actinic Keratosis epidemiology, Actinic Keratosis market valuations ...
(Date:5/3/2016)... Mo. , May 3, 2016 ... Medical Center,s Institute for Advancing Medical Innovation (IAMI) ... commercialize new drugs, diagnostics and medical devices. ... BioNovus Innovations with rights to license, develop and ... "This partnership represents a ...
(Date:5/3/2016)... TUCSON, Ariz. , May 3, 2016  As ... twice contracted rheumatic fever, which damaged his heart. ... But by June 2013, Shepherd,s heart was ... days from death. On June 20, 2013, the ... temporary Total Artificial Heart (TAH-t). Like a heart transplant, ...
Breaking Medicine Technology:
(Date:5/4/2016)... ... May 04, 2016 , ... Momsense, ... nursing mothers. The company’s patented technology, The Smart Breastfeeding Meter, is designed to ... that the technology is now available for purchase at Target.com . ...
(Date:5/4/2016)... ... May 04, 2016 , ... Francesca Loparco, Co-Founder of Queen ... forever with a same-day LASIK procedure at Christenbury Eye Center. The entrepreneur ... Christenbury performed her surgery the same day as her in-office consultation and eye exam. ...
(Date:5/4/2016)... ... May 04, 2016 , ... The preeminent surgical aftercare facility Pearl Recovery Retreat ... cancer surgery. In March 2016, the 61-year-old model and reality TV star was diagnosed ... in the milk ducts, according to an interview with the Daily Mail Online ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... coding, billing and compliance. In upcoming months, AudioEducator has lined up some informative ... conference is designed to give complete compliance know-how and practical, easy-to-apply advice. , ...
(Date:5/4/2016)... ... May 03, 2016 ... of innovative infant and child products, today revealed the non-toxic benefits ... to help babies deal with teething pain is just part of ... toxic gels, and are BPA-, PVC-, and phthalate-free. , “Many ...
Breaking Medicine News(10 mins):