Navigation Links
Circadian Receives FDA IND Approval to Begin Clinical Trials With VGX-100 for the Treatment of Cancer Patients With Solid Tumors
Date:10/31/2011

MELBOURNE, Australia, Oct. 31, 2011 /PRNewswire/ -- Circadian Technologies Limited (ASX: CIR, OTCQX: CKDXY) announces that its 100% owned subsidiary, Vegenics Pty Ltd, has received approval for its investigational new drug (IND) application from the U.S. Food and Drug Administration (FDA) to initiate clinical trials of VGX-100. The first trial (Phase I) will study VGX-100 in patients with a variety of late stage cancers.

"The FDA's acceptance of our IND represents an extremely important milestone for Circadian. We are well advanced in finalizing clinical trial sites in the USA and expect clinical trials to commence before the end of 2011 with results becoming available from the study in the second half of 2012," said Robert Klupacs, CEO of Circadian Technologies Limited.

VGX-100 is a human antibody that acts against the human VEGF-C protein. Treatment for cancers, particularly glioblastoma and metastatic colorectal cancers, are the first target indications for VGX-100. Additionally, Circadian is developing VGX-100 for a number of other cancer indications, as well as an agent to treat front-of the-eye diseases.

Studies in animal model studies across a wide range of tumour types have shown that when combined with Avastin® and chemotherapy, VGX-100 can significantly reduce tumour growth and tumour spread as well as significantly improve tumour inhibition, over and above that of Avastin® and/or chemotherapy alone. Recent studies have also implicated VEGF-C as a key mediator of disease progression during Avastin® treatment, implying that combination therapy with VGX-100 and Avastin® could significantly improve treatment outcomes in cancer patients.

Circadian's wholly owned subsidiary, Vegenics Pty Ltd, owns worldwide rights to an extensive intellectual property portfolio covering the angiogenesis and lymphangiogenesis targets VEGF-C, VEGF-D and the receptor protein VEGFR-3. Vegenics has also been granted exclu
'/>"/>

SOURCE Circadian Technologies Limited
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Circadian Files IND With FDA for VGX-100 for the Treatment of Cancer Patients With Solid Tumors
2. Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet
3. Cyberonics Receives FDA Approval for Expansion of MRI Use With VNS Therapy® Systems
4. Mylan Receives Approval for Generic Version of MS Contin® Tablets
5. SAFC Verona HPAPI Manufacturing Facility Receives SafeBridge Certification
6. INNOPHARMA Receives FDA Approval of Generic Olanzapine Injection
7. Accuray Receives 510(k) Clearance for a Rotational Dose Control for the TomoTherapy System
8. Neuralstem Receives FDA Approval to Dose Patients in Cervical Region in Ongoing ALS Trial
9. Covance Receives Good Laboratory Practice Certification for Its Early Development Facility in Shanghai, China
10. Boca Pharmacal Receives FDA Approval on Glycopyrrolate Tablets
11. Institute of Health Sciences Receives ABHES Institutional Accreditation for Long Distance Education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... 2015 A global continuing medical ... and thyroid disorders in Central and South-East ... a major conference dedicated to these diseases. ... Online , Manage Hypertension Online and ... by EXCEMED - combine the world,s top ...
(Date:7/3/2015)... , July 3, 2015 A ... of hypertension, diabetes and thyroid disorders in ... and a major conference dedicated to these diseases. ... Diabetes Online , Manage Hypertension Online and ... operated by EXCEMED - combine the world,s ...
(Date:7/3/2015)... Redwood Pharma AB has entered into a ... both the US and China , ... hydrogel technology in its lead chronic Dry Eye therapeutic ... technology offers many unique competitive benefits. At lower temperatures, ... low concentrations of polymer the system can be transitioned ...
Breaking Medicine Technology:Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2Combating Three Major Chronic Diseases in Latin America With Medical Education 2Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2
... About Medicare Reimbursement, State Medicaid Budget Crisis , ... Snowe,s remarks yesterday recognizing the unique funding challenges faced ... nation,s oldest, most vulnerable citizens, the President and CEO ... and the President of the Alliance for Quality Nursing ...
... PITTSBURGH, Oct. 14 Mylan Inc. (Nasdaq: MYL ) ... live webcast on Thursday, Oct. 29, 2009, at 10:00 a.m. ... quarter 2009, which ended Sept. 30. Mylan will release its ... The dial-in number to access the Oct. 29 call is ...
Cached Medicine Technology:National Long Term Care Leaders Praise Senator Snowe's Recognition of Nursing Homes' Unique Funding Challenges in Caring for Nation's Seniors 2
(Date:7/3/2015)... ... July 03, 2015 , ... The Celebrity Dresses is currently running a promotion ... of celebrities will have the opportunity to get 10% discount on orders that are ... do not have to use coupon codes or remember redemption codes. , There ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening ... located in the Lone Star State. The premium frozen yogurt chain was listed as #22 ... opened June 19 in the Village at Bachman Lake, is located at:, 3701 W. Northwest ...
(Date:7/2/2015)... ... July 02, 2015 , ... Following the recent report by JAMA ... Americans outnumber merely overweight Americans, Samir Becic emphatically declared a war on obesity in ... right now," Becic said. "We must understand the magnitude of this discovery. For that ...
(Date:7/2/2015)... ... July 02, 2015 , ... When ... project at the University of Minnesota, they knew it would save the university ... be an award-winning choice: the total energy savings after installation was an impressive ...
(Date:7/2/2015)... ... 2015 , ... With summer in full swing, Americans are flocking to Canada’s many lakes to ... for fishing in the world, and it’s easy to understand why. From the Pacific Northwest ... , Recreational fishing is a huge industry, and Americans make up the vast majority ...
Breaking Medicine News(10 mins):Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2
... risk factors of heart disease, which can in the future ... of the Walter Reed Army Institute of Research in Silver ... development of atherosclerosis, or hardening of the arteries, and described ... such as high cholesterol. , , ...
... A new breakthrough using gene therapy mouthwash promises good results ... cancer by destroying suspicious growths in the mouth before they ... by unleashing viruses, which kills cells that contain cancer-causing genes. ... is the first study of its kind, scientists are enthusiastic, ...
... Mayo Foundation in Rochester, Minnesota has created a break ... the digestive tract of people afflicted with gastrointestinal cancers. ... patients commonly suffer from obstructions and they present with ... in the esophagus; they might present with other symptoms ...
... pathways and mechanisms of diabetes. It is fascinating." Yes the ... the identification of the missing protein in the adult onset ... They have discovered that mice lacking a gene that ... born without diabetes but develop symptoms of glucose intolerance after ...
... is a type of disease, that requires insulin injections ... cure for this disease. Some medical research centers in ... severe Type I diabetes by transplanting insulin-producing islet cells ... able to live normal lives without insulin. , ...
... which has the ability to slow down cancer growth ... people each year, and luckily tthe discovery of the ... of the colon, prostate,pancreas,brain and bowel. ,Sox regulates ... the cancer by starving the tumour cells.// ...
Cached Medicine News:Health News:Fight oral cancer with gene therapy mouthwash, 2Health News:Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes? 2Health News:Transplant helps diabetes 2
Whether you require high flow rates for critical situations or lower rates for others, this insufflator handles both situations equally well, regulated by the preselected pressure....
Stryker's 40-liter insufflator provides superior performance with unprecedented safety and reliability....
Bipolar forceps...
... HPV allows the pathologist to visualize the presence ... testing on a choice of sample types: tissue, ... cocktails utilize proprietary probe formulations. The Family 16 ... 16, 18, 31, 33, 35, 39, 51, 52, ...
Medicine Products: