Navigation Links
Circadian Receives FDA IND Approval to Begin Clinical Trials With VGX-100 for the Treatment of Cancer Patients With Solid Tumors
Date:10/31/2011

MELBOURNE, Australia, Oct. 31, 2011 /PRNewswire/ -- Circadian Technologies Limited (ASX: CIR, OTCQX: CKDXY) announces that its 100% owned subsidiary, Vegenics Pty Ltd, has received approval for its investigational new drug (IND) application from the U.S. Food and Drug Administration (FDA) to initiate clinical trials of VGX-100. The first trial (Phase I) will study VGX-100 in patients with a variety of late stage cancers.

"The FDA's acceptance of our IND represents an extremely important milestone for Circadian. We are well advanced in finalizing clinical trial sites in the USA and expect clinical trials to commence before the end of 2011 with results becoming available from the study in the second half of 2012," said Robert Klupacs, CEO of Circadian Technologies Limited.

VGX-100 is a human antibody that acts against the human VEGF-C protein. Treatment for cancers, particularly glioblastoma and metastatic colorectal cancers, are the first target indications for VGX-100. Additionally, Circadian is developing VGX-100 for a number of other cancer indications, as well as an agent to treat front-of the-eye diseases.

Studies in animal model studies across a wide range of tumour types have shown that when combined with Avastin® and chemotherapy, VGX-100 can significantly reduce tumour growth and tumour spread as well as significantly improve tumour inhibition, over and above that of Avastin® and/or chemotherapy alone. Recent studies have also implicated VEGF-C as a key mediator of disease progression during Avastin® treatment, implying that combination therapy with VGX-100 and Avastin® could significantly improve treatment outcomes in cancer patients.

Circadian's wholly owned subsidiary, Vegenics Pty Ltd, owns worldwide rights to an extensive intellectual property portfolio covering the angiogenesis and lymphangiogenesis targets VEGF-C, VEGF-D and the receptor protein VEGFR-3. Vegenics has also been granted exclu
'/>"/>

SOURCE Circadian Technologies Limited
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Circadian Files IND With FDA for VGX-100 for the Treatment of Cancer Patients With Solid Tumors
2. Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet
3. Cyberonics Receives FDA Approval for Expansion of MRI Use With VNS Therapy® Systems
4. Mylan Receives Approval for Generic Version of MS Contin® Tablets
5. SAFC Verona HPAPI Manufacturing Facility Receives SafeBridge Certification
6. INNOPHARMA Receives FDA Approval of Generic Olanzapine Injection
7. Accuray Receives 510(k) Clearance for a Rotational Dose Control for the TomoTherapy System
8. Neuralstem Receives FDA Approval to Dose Patients in Cervical Region in Ongoing ALS Trial
9. Covance Receives Good Laboratory Practice Certification for Its Early Development Facility in Shanghai, China
10. Boca Pharmacal Receives FDA Approval on Glycopyrrolate Tablets
11. Institute of Health Sciences Receives ABHES Institutional Accreditation for Long Distance Education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... 2015 The breakthrough hepatitis C treatment, Sovaldi ... manufacturer Gilead Sciences overcame initial market resistance through its ... relations campaigns. Sovaldi,s high cure rate, short ... propelled the drug to $2.3 billion in sales during ... on the market. But Sovaldi,s price tag of $84,000 ...
(Date:5/1/2015)... 01, 2015 /PRNewswire/ --Research and Markets ( ... Clinical Chemistry Analyzer Market by Product, by End-Users - Forecast ... American Clinical Chemistry Analyzers market is estimated to grow at ... as the U.S., Canada , ... of Americas (RoA) are covered in this report. ...
(Date:5/1/2015)... LITTLE FALLS, N.J. , May 1, 2015 ... Andrew A. Krakauer , Chief Executive Officer, will be ... Conference at the Encore at the Wynn in ... for Thursday, May 14, 2015 at 10:00 AM PT/1:00 PM ... meetings during the day. An audio webcast ...
Breaking Medicine Technology:New Study Examines Success Lessons of Sovaldi's and Harvoni's Blockbuster Launches 2Americas Clinical Chemistry Analyzer (Semi-Automated Clinical Chemistry and Fully-Automated Clinical Chemistry) Market - Forecast to 2019 2
... QUAD Cinema , one of New York City,s leading art ... documentary, 3 BILLION AND COUNTING (102 ... Sure to spark outrage, Dr. Rutledge, a California physician ... ban on the pesticide DDT in 1972, a ban inspired ...
... The following is a statement issued today ... and CEO Steven C. Anderson, IOM, CAE, and National ... CEO Douglas Hoey, RPh, regarding the proposed rule by ... would withdraw existing provisions of the Medicaid pharmacy reimbursement ...
Cached Medicine Technology:3 BILLION AND COUNTING Opens in New York at The QUAD Cinema 23 BILLION AND COUNTING Opens in New York at The QUAD Cinema 3NACDS, NCPA: Victory for Patients, Pharmacy as CMS Moves to Withdraw Provisions of 'AMP' Rule Currently Blocked by Injunction 2NACDS, NCPA: Victory for Patients, Pharmacy as CMS Moves to Withdraw Provisions of 'AMP' Rule Currently Blocked by Injunction 3
(Date:5/2/2015)... FL (PRWEB) May 02, 2015 We ... selected The Delray Recovery Center as one of the ... is known in the addiction treatment field for their ... members to innovate and to continue their educational efforts. ... positive workplace environment, never forgetting their purpose – to ...
(Date:5/2/2015)... On Tuesday April 7th, the patient care ... celebrate improvements in patient care. In 2014 the hospital, ... zero acquired ventilator associated infections, zero central line associated ... also recently named a Top Performer by the Joint ... the teamwork of staff from all departments involved in ...
(Date:5/2/2015)... As a nonsurgical staple in ... face, neck and décolleté, radiofrequency energy is proving ... for the success of vulvovaginal rejuvenation. In a ... Council, ThermiGyn’s Women’s Health Clinical Advisory Board Chairman ... ThermiGyn’s temperature controlled radio frequency, specifically that of ...
(Date:5/2/2015)... With the success that Veatch Dental Consulting has ... Neida Miranda and Alex Shields to the team. With Neida ... years of combined experience working with dentists to ensure their ... for 8 years. She was certified as dental assistant ... positive attitude and showing the importance of oral hygiene to ...
(Date:5/1/2015)... and Caicos Islands, BWI (PRWEB) May 02, 2015 ... new website! It is http://www.thevenetiangracebay.com , and ... and it incorporates the stunning white and attractive turquoise ... a study of Google, sixty seven percent of leisure ... The study showed that smartphones were used in the ...
Breaking Medicine News(10 mins):Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 3Health News:Veatch Dental Consulting Services Welcomes New Team Members 2Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2
... TeleHealth Services , the nation,s ... staff interactive education solutions, today announced they will be ... the annual Healthcare Information and Management Systems Society (HIMSS) ... on-demand patient and staff education system, has been installed ...
... today announced the introduction of DNA shearing service ... years, Covaris instruments have become the gold standard ... step for next generation sequencing. The Covaris ... sequencing platforms. This process is highly reproducible ...
... Standards within HIT Solutions to Help Improve Patient ... Greenway Medical Technologies Inc., a leading ... practice management and interoperability solution has announced its ... Society (HIMSS) and Integrating the Health Enterprise (IHE) ...
... Ind., April 2 Despite government efforts to address ... 1998 Racial and Ethnic Health Disparities Initiative, there has ... and early death than Caucasians(1).The statistics are alarming:, ... African-Americans are 1.6 times more likely to have ...
... bouts of excessive consumption, CDC notes , , THURSDAY, April 2 ... most common among whites, males, people ages 18 to 34, ... to a study released Thursday. , The study defined binge ... , The U.S. Centers for Disease Control and Prevention (CDC) ...
... Discovery could lead to ways of regrowing damaged cardiac tissue, ... a longstanding mystery, scientists have found that the human heart ... although the rate of new cell production slows with age. ... of Science , could open a new path for ...
Cached Medicine News:Health News:TeleHealth Services Announces TIGR On-Demand Video Patient Education Version 7 Unveiling at HIMSS 2009 2Health News:TeleHealth Services Announces TIGR On-Demand Video Patient Education Version 7 Unveiling at HIMSS 2009 3Health News:Covaris Introduces DNA Shearing Service 2Health News:Greenway Medical Technologies Continues to Champion Interoperability Efforts with Extensive Participation in HIMSS' 2009 Interoperability Showcase 2Health News:Greenway Medical Technologies Continues to Champion Interoperability Efforts with Extensive Participation in HIMSS' 2009 Interoperability Showcase 3Health News:Greenway Medical Technologies Continues to Champion Interoperability Efforts with Extensive Participation in HIMSS' 2009 Interoperability Showcase 4Health News:Health Disparities Among Minority Populations Getting Worse 2Health News:Health Disparities Among Minority Populations Getting Worse 3Health News:Typical Binge Drinker Is Young White Male 2Health News:Human Heart Can Make New Cells 2Health News:Human Heart Can Make New Cells 3
... cardiovascular system PLUS ... high-performance transesophageal cardiovascular imaging system ... phased array echocardiography system that ... images, even on your most ...
MAGNETOM Symphony, an imaging system that offers 1.5T performance and top image quality in a short bore design....
MAGNETOM Avanto, the worlds first Tim MRI system, provides unsurpassed image quality, enhanced productivity, and greater patient comfort....
... Medical Billing Assistant (MBA) ... medical billing and practice management ... on Microsoft SQL Server technology ... reporting capabilities and account receivable ...
Medicine Products: