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Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients
Date:1/8/2012

r growth through their anti-angiogenic activities, but to also inhibit tumour spread or metastasis via the lymphatic vessels - a mechanism of tumour dissemination that is often the deadliest aspect of many tumour types and a mechanism that is not effectively blocked by anti-VEGF-A or anti-VEGFR-2 therapeutics.

Inherent risks of Investment in Biotechnology CompaniesThere are a number of inherent risks associated with the development of pharmaceutical products to a marketable stage.  The  lengthy  clinical  trial  process  is  designed  to  assess  the  safety  and  efficacy  of  a  drug  prior  to commercialisation and  a  significant  proportion of drugs fail one or both of these  criteria. Other  risks  include uncertainty of patent protection and proprietary rights,  whether patent applications and issued patents  will offer adequate protection to enable product development, the obtaining of necessary drug regulatory authority approvals and difficulties caused by the rapid advancements in technology.  Companies such as Circadian are dependent on the success  of their research and development projects and on the ability to attract funding to support these activities.  Investment in research and development projects cannot be assessed on the same fundamentals as trading and manufacturing enterprises.  Thus investment in companies specialising in drug development must be regarded as highly speculative. Circadian strongly recommends that professional investment advice be sought prior to such investments.Forward-looking statementCertain statements in this ASX announcement may contain forward-looking statements regarding Company business and the therapeutic and commercial potential  of its technologies and products in development.  Any  statement describing Company goals, expectations
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