Navigation Links
Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients
Date:1/8/2012

rights to some parts of its intellectual property portfolio for the development of other products to ImClone Systems, a wholly-owned subsidiary of Eli Lilly and Company, including the antibody IMC-3C5 targeting VEGFR-3.
www.circadian.com.au

About Circadian's pipeline of treatments for cancerThe clinical and commercial success of Avastin®, an antibody that blocks the activity of VEGF-A, clinically validated anti-angiogenic drugs as an effective means of inhibiting solid tumour growth.  By blocking the interaction of VEGF- A with its receptors, primarily VEGFR-2, the multi-billion dollar cancer therapeutic slows tumour growth by inhibiting blood vessel recruitment into the tumour, effectively starving tumours of essential nutrients and oxygen required for growth. However after a short period of time tumors can begin to grow again in the presence of Avastin®. Avastin® is approved  by the US FDA in the following indications: metastatic colorectal cancer, non-squamous-cell lung cancer, glioblastoma, and metastatic renal cell carcinoma. In Europe it is approved for the additional indications of ovarian cancer and breast cancer.

The angiogenic receptor VEGFR-2 can also be stimulated by VEGF-C and hence an inhibitor such as VGX-100, a key therapeutic in Circadian's portfolio, can produce greater blockade of this receptor pathway when  used in combination with VEGF-A inhibitors.  As such, VGX-100 has the potential to block blood vessel growth in tumours which grow despite ongoing  Avastin® therapy and hence may completely shut down angiogenesis (the growth of blood vessels) mediated by VEGFR-2.

VEGF-C, along with the molecule VEGF-D, are also the only known proteins to bind and activate VEGFR-3 which drives lymphatic vessel and tumour-associated blood vessel growth.  Inhibitors of VEGF-C thus have therapeutic potential to inhibit not only primary tumou
'/>"/>

SOURCE Circadian Technologies Limited
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Circadiance Launches Revolutionary New CPAP Tube
2. Circadian Receives FDA IND Approval to Begin Clinical Trials With VGX-100 for the Treatment of Cancer Patients With Solid Tumors
3. Circadian Files IND With FDA for VGX-100 for the Treatment of Cancer Patients With Solid Tumors
4. Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet
5. Ikaria® Commences Global Registration Trial for Bioabsorbable Cardiac Matrix
6. Coronado Biosciences Commences Public Trading on the OTC Bulletin Board
7. Hotspur Technologies Commences US Launch at Veith/AIM Conference in New York City
8. CryoLife Commences Tender Offer for All Outstanding Shares of Cardiogenesis Corporation
9. Unilife Commences Initial Production of Unifill Prefilled Syringe
10. Quest Diagnostics Commences Tender Offer for Acquisition of Celera
11. Milestone Scientific Inc. Commences Trading on the OTC Pink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 2014 Medina Medical announced today that Mr. ... the Board of Directors on August 18, 2014. Mr. ... commercialization experience, including over a decade of direct experience ... a Partner of the medical device incubator The Foundry, ... Foundry start-ups. Mr. Engelson previously served as the Chief ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "China Orthopedic Instrument Industry Report, 2014-2017" report to ... population and rising proportion of reimbursement for medical expenses, ... released, with its scale presenting a CAGR of 19.2% ... are three product segments of orthopedic instruments in ...
(Date:8/29/2014)... 29, 2014 According to ... by Extraction type (SFE, Cold Pressed, Organic Solvent, & ... Pharmaceutical, Food Supplements, Fragrance, & Others) - Global Trends ... and segments the Amaranth Seed Oil Market with ... in terms of value. The Amaranth Seed Oil ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2China Orthopedic Instrument Industry Report, 2014-2017 2Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4
... Calif., July 26, 2011 Epitomics, Inc., a ... based on its groundbreaking Rabbit Monoclonal (RabMAb®) technology, ... novel cancer-related antibodies that were developed through a ... Cancer Research. The goal of this partnership is ...
... 26, 2011 Bacterin International Holdings, Inc. ... the development of revolutionary bone graft material and anti-infective coatings ... August 11, at 4:30 p.m. Eastern time to discuss results ... will be issued in a press release after the close ...
Cached Medicine Technology:Epitomics Releases New Antibodies Developed With the National Cancer Institute's Center for Cancer Research 2Bacterin Sets Second Quarter 2011 Conference Call for Thursday, August 11, 2011 at 4:30 p.m. ET 2
(Date:8/29/2014)... review website Top10BestSEOHosting.com compares many popular hosting suppliers and ... suppliers for webmasters for webmasters who want to buy ... at affordable prices. , GoDaddy offers three Linux ... plans depends on the length of a contract. This ... flexible hosting packages, decent uptime record and beneficial support ...
(Date:8/29/2014)... Cosmetic Town has devised a system ... its doctors. Cosmetic Town utilizes a validated referral ... in their field are chosen to present their procedure. ... direct link to potentially hundreds of recommended doctors in ... to communicate through the site’s community features and multimedia ...
(Date:8/29/2014)... a famous online supplier of trendy clothes, has unveiled its ... moment, all these mini outfits are offered at discounted rates, ... is September 14. , The company’s senior spokesman states, ... hot designs, we have listed some of the best-selling items ... ladies to get high quality, fashionable clothes. Many of our ...
(Date:8/29/2014)... Panic attacks are extremely difficult to ... intense stress and fear, which appears with no particular ... insecurity and affecting relationships. , A panic attack can ... symptoms that patients can deal with. Anxiety, shortness of ... panic attacks is extremely important for sufferers, who need ...
(Date:8/29/2014)... DailyGossip.org publishes a review to the Natural Multiple ... curing multiple sclerosis in a fast and natural way. ... M. Levin, who has become well known as a ... alternative remedies for a series of health problems when ... all cases for the cure of some disorders. ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town Now Advocates for the Rights of Cosmetic Patients Using Novel Approach 2Health News:Cheap Sexy Mini Dresses Added To The Product Line Of Skmen.com 2Health News:60 Second Panic Solution Review Exposes Simple Panic Attacks Remedy 2Health News:New Natural Multiple Sclerosis Treatment Review Reveals Gary M. Levin’s Unique Cure 2
... undergo heart surgery are more than three times as likely ... the next three months, a new study finds. ... during the most critical post-operative recovery period," says Ellen Idler, ... study, which appears in the March issue of the ...
... The Center for Public-Private Partnerships at The Henry M. ... is pleased to announce the recipients of the 2012 ... themselves through excellence and selfless dedication to advancing medicine ... veterans and their families. The recipients will be honored ...
... are vitamin D deficient and there is an inverse ... a recent study accepted for publication in The Endocrine ... (JCEM). Recommendations for dietary vitamin D intake in ... because vitamin D deficiency is extraordinarily prevalent in this ...
... D.C. People with schizophrenia report improved functioning ... according to results announced today from a six-month ... for People with Schizophrenia , was spearheaded by ... Council) and administered at 10 community behavioral health ...
... HealthDay Reporter , MONDAY, March 5 (HealthDay News) ... College of Physicians (ACP) put the emphasis on individual risk. ... get screened starting at age 50, whereas people at high ... or family history of the disease -- should get screened ...
... (HealthDay News) -- ,Hospitalizations from angiodema, a serious swelling ... the eyes and mouth, are on the rise, new ... searched a national database for hospitalizations due to allergic ... and angiodema. While hospitalization rates for the other ...
Cached Medicine News:Health News:Marriage: A powerful heart drug in short supply 2Health News:HJF Center announces Heroes of Military Medicine award recipients 2Health News:Vitamin D deficiency linked to higher mortality in female nursing home residents 2Health News:Pilot program demonstrates measureable benefits for people with schizophrenia 2Health News:New Colon Cancer Screening Guidelines Focus on Individual Risk 2Health News:New Colon Cancer Screening Guidelines Focus on Individual Risk 3
SkinStation, powered by LHE, is Radiancys flagship product. A powerhouse by design, it incorporates todays most sought after applications all on one user-friendly system ....
Inquire...
Sebia's Hb AFSC Control provides excellent resolution of normal hemoglobins A & F and abnormal hemoglobins S & C. The control is designed for use with Sebia's Hydragel Hemoglobin and Hydragel Acid He...
... Normal and Hypergamma Controls are ... either agarose gels or Sebia's ... Our unique control manufacturing process ... the other serum components, presenting ...
Medicine Products: