Navigation Links
Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients
Date:1/8/2012

rights to some parts of its intellectual property portfolio for the development of other products to ImClone Systems, a wholly-owned subsidiary of Eli Lilly and Company, including the antibody IMC-3C5 targeting VEGFR-3.
www.circadian.com.au

About Circadian's pipeline of treatments for cancerThe clinical and commercial success of Avastin®, an antibody that blocks the activity of VEGF-A, clinically validated anti-angiogenic drugs as an effective means of inhibiting solid tumour growth.  By blocking the interaction of VEGF- A with its receptors, primarily VEGFR-2, the multi-billion dollar cancer therapeutic slows tumour growth by inhibiting blood vessel recruitment into the tumour, effectively starving tumours of essential nutrients and oxygen required for growth. However after a short period of time tumors can begin to grow again in the presence of Avastin®. Avastin® is approved  by the US FDA in the following indications: metastatic colorectal cancer, non-squamous-cell lung cancer, glioblastoma, and metastatic renal cell carcinoma. In Europe it is approved for the additional indications of ovarian cancer and breast cancer.

The angiogenic receptor VEGFR-2 can also be stimulated by VEGF-C and hence an inhibitor such as VGX-100, a key therapeutic in Circadian's portfolio, can produce greater blockade of this receptor pathway when  used in combination with VEGF-A inhibitors.  As such, VGX-100 has the potential to block blood vessel growth in tumours which grow despite ongoing  Avastin® therapy and hence may completely shut down angiogenesis (the growth of blood vessels) mediated by VEGFR-2.

VEGF-C, along with the molecule VEGF-D, are also the only known proteins to bind and activate VEGFR-3 which drives lymphatic vessel and tumour-associated blood vessel growth.  Inhibitors of VEGF-C thus have therapeutic potential to inhibit not only primary tumou
'/>"/>

SOURCE Circadian Technologies Limited
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related medicine technology :

1. Circadiance Launches Revolutionary New CPAP Tube
2. Circadian Receives FDA IND Approval to Begin Clinical Trials With VGX-100 for the Treatment of Cancer Patients With Solid Tumors
3. Circadian Files IND With FDA for VGX-100 for the Treatment of Cancer Patients With Solid Tumors
4. Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet
5. Ikaria® Commences Global Registration Trial for Bioabsorbable Cardiac Matrix
6. Coronado Biosciences Commences Public Trading on the OTC Bulletin Board
7. Hotspur Technologies Commences US Launch at Veith/AIM Conference in New York City
8. CryoLife Commences Tender Offer for All Outstanding Shares of Cardiogenesis Corporation
9. Unilife Commences Initial Production of Unifill Prefilled Syringe
10. Quest Diagnostics Commences Tender Offer for Acquisition of Celera
11. Milestone Scientific Inc. Commences Trading on the OTC Pink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... , May 23, 2013  A recently published ... Houston, Texas , demonstrates that 3D ... increasing cancer detection. The study, "Implementation ... Observational Study," was led by Stephen L. ... issue of the American Journal of Roentgenology ...
(Date:5/23/2013)... 23, 2013  The need to add tissue ... was highlighted prominently at the 108 th ... in San Diego.  According to SonaCare Medical, a ... (HIFU) technology, the need for image-guided technologies to ... to consider minimally invasive ablative treatments, was addressed ...
(Date:5/23/2013)...  Hologic, Inc. (Hologic or the Company) (NASDAQ: ... and supplier of premium diagnostics, medical imaging systems ... the healthcare needs of women, today announced that ... clinical practice comparing breast cancer screening with Hologic,s ... mammography alone showed a significant reduction in recall ...
Breaking Medicine Technology:First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 2First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... in Psychiatry , , HARTFORD, Conn., ... current issue of the Future Medicine Group (London) journal ... are helping to point the way toward the application of DNA-guided ... The Institute of Living of Hartford Hospital in collaboration with Genomas. ...
... The Takeda Oncology Company today reported updated results ... the large, international Phase III VISTA(1) trial showing ... multiple myeloma given VELCADE, melphalan and prednisone (VcMP). ... patient sub-groups, including those with poor prognostic characteristics, ...
Cached Medicine Technology:Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects 2Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 2Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 3Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 4Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 5Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 6
(Date:5/24/2013)... Atlanta, GA (PRWEB) May 24, 2013 Started ... convention held in Orlando. 2013 marks AMTC’s 31st anniversary. ... same family, starting with supermodel Millie Lewis and her daughter, ... by top agents, managers, casting directors, and music professionals including ... Dramatic Arts and XP Media. They are kings of Hollywood ...
(Date:5/24/2013)... failed to replicate what appeared to be breakthrough results ... were published last year in the journal Science ... suggested that the drug bexarotene (marketed as Targretin) could ... a pathological hallmark of Alzheimer,s disease in ... the 2012 report, drug treatment quickly removed most of ...
(Date:5/24/2013)... City, Utah (PRWEB) May 24, 2013 ... , with exciting new enhancements for instructors and students. ... stay more focused through personalize learning plan templates, targeted ... AnatomyOne release provides 500 new assessment questions, 5,000 searchable ... review notes. , AnatomyOne 2.0 is the ...
(Date:5/24/2013)... Los Angeles, CA (PRWEB) May 24, 2013 ... is to present the 3rd Annual EB-5 Investment Summit: ... 2013. The Dealmakers Conference will focus on exploring alternative ... provide the latest market, legal and economic information, and ... legal professionals within the EB-5 industry. , "Our ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Dwell ... VP, Brandon Huff as Executive Vice President of Digital ... business units, which represented a large portion of Yahoo's ... growth as Dwell develops a fully-integrated commerce unit to ... of experience monetizing digital content for leading firms in ...
Breaking Medicine News(10 mins):Health News:AMTC’s Summer SHINE Event Coming to Orlando’s Luxurious Gaylord Palms July 2-7, 2013 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Amirsys AnatomyOne 2.0 Delivers Personalized Learning Plans 2Health News:Brian Su Organizes 3rd Annual EB-5 Investment Conference in Long Beach, California 2Health News:Yahoo Commerce Head Joins Leadership at Dwell Media 2
... system for measuring brain tissue with magnetic resonance imaging ... at an earlier stage according to a new study ... Radiology . , In Alzheimer,s disease, nerve cell death ... especially the hippocampus region, to shrink. MRI with high ...
... XM 157 on XM Satellite Radio,and The United ... of a new 13 week programming series designed ... clinical trauma, internal,medicine, medical education and much more., ... and educate medical,professionals and those interested in a ...
... 23 Colonial Life & Accident,Insurance Company has set up dedicated ... in the Midwest to get support from the,company., (Logo: ... centers toll free at these,numbers:, Policyholders: ... Brokers: ...
... They resulted in 8,000 deaths, 56,000 hospitalizations for those ... June 23 (HealthDay News) -- In 2005, traumatic brain ... deaths and 56,000 hospitalizations among Americans age 65 and ... and Prevention study. , TBIs accounted for ...
... Medical Association Provides Tips on Caring for Your ... ... teenagers,love horses and often parents buy or lease a horse for their ... of a horse can be wonderful but a,time-consuming responsibility," said Dr. Jeff ...
... prohibitive, experts say , , MONDAY, June 23 (HealthDay News) -- ... overall death risk for American adults, a new study suggests. ... of who will have a problem and who will not," ... at the Harbor-UCLA Medical Center. , He and his colleagues ...
Cached Medicine News:Health News:Automated MRI technique assists in earlier Alzheimer's diagnosis 2Health News:The United States Army Medical Department Announces the Launch of an Innovative New Programming Series Called 'The Strength to Heal' That Will Run on ReachMD XM 157 - The Channel for Medical Professionals on XM Radio. 2Health News:The United States Army Medical Department Announces the Launch of an Innovative New Programming Series Called 'The Strength to Heal' That Will Run on ReachMD XM 157 - The Channel for Medical Professionals on XM Radio. 3Health News:Support Numbers for Colonial Life & Accident Insurance Company Customers Affected by Floods 2Health News: Senior Falls Can Lead to Brain Injury 2Health News:Saddle Up! Getting a Jump on Proper Horse Care 2Health News:Arterial Calcium Scans Can Predict Death Risk 2Health News:Arterial Calcium Scans Can Predict Death Risk 3Health News:Arterial Calcium Scans Can Predict Death Risk 4
... V is a low viscosity bone cement, ... vertebroplasty. The bone cement is injected into ... Osteopal V is used for the augmentation ... zirconium dioxide is included in the cement ...
... to fuse multiple image sets in seconds, ... treatment planning and follow-up. ImageFusion aligns images ... features of different scan types. Radionics supports ... clinicians can capitalize on the unique strengths ...
... The Framelink Stereotactic Linking System simplifies ... Brain Stimulation (DBS). This software integrates ... and microelectrode recording data, to assist in ... deep brain target location. Framelink interfaces ...
It provides cranial support in either supine or semi-sitting procedures....
Medicine Products: