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Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients
Date:1/8/2012

progression during Avastin® treatment, implying that combination therapy with VGX-100 and Avastin® could significantly improve treatment outcomes in cancer patients.

Circadian's wholly owned subsidiary, Vegenics Pty Ltd, owns worldwide rights to an extensive intellectual property portfolio covering the angiogenesis and lymphangiogenesis targets VEGF-C, VEGF- D and the receptor protein VEGFR-3.  Vegenics has also been granted exclusive worldwide rights to intellectual property filed by Schepens Eye Research Institute covering the use of anti-lymphangiogenic molecules for the treatment of Dry Eye Disease.Company Enquiries:

Media Enquiries – International:  

 Robert Klupacs

Lauren Glaser Managing Director - Circadian

The Trout Group LLC Tel: +61 (0) 3 9826 0399 or

251 Post Street, Suite 412 robert.klupacs@circadian.com.au 

San Francisco, CA 94108  

Tel +1 215 740 8468  

lglaser@troutgroup.comAbout Circadian Technologies LimitedCircadian (ASX:CIR; OTCQX:CKDXY) is a biologics drug developer focusing on cancer and 'front of the eye' disease therapies.  It controls exclusive worldwide rights to a significant intellectual property portfolio around Vascular Endothelial Growth  Factor  (VEGF)-C and -D. The  applications for the  VEGF technology,  which functions in regulating blood and lymphatic vessel growth, are substantial  and broad. Circadian's internal product development programs are primarily focussed on  developing  VGX-100 (a human antibody against  VEGF-C) as a treatment for solid tumours, in particular glioblastoma and colorectal cancer, as well as for 'front of the eye' disease such as corneal neovascularisation and/or corneal allograft rejection.  Circadian has also licensed
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