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Cinryze® (C1 Esterase Inhibitor [Human]) Data Presented at 2011 American Academy of Allergy Asthma & Immunology (AAAAI) Annual Meeting
Date:3/22/2011

IV was administered within 24 hours before a procedure.  The results cited on the poster included the following:

  • Forty-one unique subjects (8 children, 33 adults) received Cinryze for 91 procedures (40 in children, 51 in adults);
  • Approximately 55 percent of procedures involved dental work and 37 percent involved surgeries or interventional diagnostic procedures.  Among the 8 children (aged 6-17 years), 90 percent of procedures involved dental work;
  • Pre-procedural administration of Cinryze prevented HAE attacks during or following 98 percent of medical, dental, or surgical procedures;
  • Only 2 HAE attacks were reported within 72 hours after dosing: 1 genitourinary attack after dental work and 1 laryngeal attack after laparoscopy. Both resolved after treatment with an additional dose of Cinryze;
  • Seven subjects reported adverse events within 7 days after receiving Cinryze; none were considered related to Cinryze by the investigator.  

In a poster entitled, 'Safety and Efficacy of Nanofiltered C1 Esterase Inhibitor (human) (Cinryze®) for the Treatment of Laryngeal Attacks in Subjects with Hereditary Angioedema (HAE),' Dr. Marc Riedl, M.D., of the University of California, Los Angeles, David Geffen School of Medicine presented the experience of 85 subjects who received Cinryze to treat 267 laryngeal attacks of HAE.  These data were compiled from all completed studies with Cinryze.  These subjects received Cinryze 1000U IV for HAE attacks; a second 1000U dose could be administered 1 hour later if necessary. The results cited on the poster included the following:

  • Across all studies, 85 unique subjects (74 adults, 11 children) received Cinryze for treatment of 267 laryngeal attacks; of them, only 1 subject required intubation;
  • Four subjects reported SAEs that were not HAE manifestations; none were consid
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SOURCE ViroPharma Incorporated
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