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Cinryze® (C1 Esterase Inhibitor [Human]) Data Presented at 2010 International Scientific Conference of the World Allergy Organization (WAO)
Date:12/6/2010

ence of transmission of HBV, HCV, or HIV, and no clinically relevant anti-C1 inhibitor antibodies developed

In a poster entitled, 'Open-Label Use of Nanofiltered C1 Esterase Inhibitor (human) (nf-C1 INH) for the Prophylaxis of Attacks of Hereditary Angioedema (HAE) in Pediatric Subjects,' Dr. Colin Broom M.D., ViroPharma Incorporated, Exton, PA, presented new open label results of Cinryze in preventing HAE attacks in 23 pediatric patients with HAE.  Data from this study included the following:

  • Cinryze reduced the frequency of HAE attacks from a median of 3.0 attacks per month at baseline to 0.39 attacks per month during Cinryze prophylaxis
  • In children, prophylactic doses of 1000 U of Cinryze every 3 to 7 days resulted in increases in antigenic and functional C1-INH levels comparable to those seen in adults; increases in functional C1-INH activity were maintained over time
  • There were no severe hypersensitivity reactions related to Cinryze; no discontinuations from study due to adverse events; no detectable anti-C1 INH antibodies; and no evidence of transmission of HBV, HCV, or HIV;
  • Adverse events considered to be possibly, probably, or definitely related to Cinryze were headache, nausea, and infusion site erythema, none of which were considered severe.

In addition, the WAO has joined with The American College of Allergy, Asthma and Immunology (ACAAI) and the American Gastroenterological Association (AGA) Institute in an innovative  initiative called "HAE:  Learn About It, Talk About It."  The peer-driven campaign is designed to foster communication between physicians on the front lines of the diagnosis and management of HAE. The addition of WAO as a "Learn About It, Talk About It" partner expands the program to a global audience. The program will be highlighted in booth 13 at the WAO meeting.


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SOURCE ViroPharma Incorporated
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1. ViroPharma Receives Complete Response Letter for Cinryze™ (C1 Esterase Inhibitor [Human]) Industrial Scale Supplement
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3. ViroPharma Files Prior Approval Supplement (PAS) for Cinryze™ (C1 Esterase Inhibitor [Human]) Industrial Scale Manufacturing
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