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Cinryze® (C1 Esterase Inhibitor [Human]) Data Presented at 2010 International Scientific Conference of the World Allergy Organization (WAO)
Date:12/6/2010

ed as unequivocal relief or the presence of one or two consecutive 15 minute assessments consistent with improvement immediately prior to discharge, occurred in 73 percent of attacks within one hour, and 95 percent within four hours;
  • 65 percent of laryngeal attacks achieved unequivocal relief or at least one report consistent with improvement immediately prior to discharge within one hour, and 90 percent within four hours;
  • Of the 84 laryngeal attacks, none required intubation after the receipt of Cinryze;
  • Responses to Cinryze in subjects with more than one attack did not diminish with subsequent repeated administration;
  • Infusion site pain, joint swelling, rash, and sinusitis were reported as treatment-emergent Cinryze-related adverse events.  

  • In a poster entitled, "Open-Label Use of Nanofiltered C1 Esterase Inhibitor (Human) (nf-C1 INH) for Treatment of Acute Attacks of Hereditary Angioedema (HAE) in Pediatric Subjects,' Dr. Timothy Craig, M.D. of the Hershey Medical Center in Harrisburg, PA, presented open label experience with Cinryze in treating 121 HAE attacks in 22 pediatric patients with HAE. Data from this study included the following:

    • The overall median time to beginning of relief of all attacks was 15 minutes;
    • Overall response rates within 4 hours were 89 to 97 percent for unequivocal relief and clinical relief, respectively;
    • No subjects with a laryngeal attack required intubation;
    • In subjects who were treated for multiple attacks, repeated therapy with Cinryze did not diminish the response to treatment;
    • Of the 121 acute attacks treated with Cinryze, 88 attacks were treated with one dose of Cinryze; 33 attacks required two doses;
    • There were no serious adverse events, and no adverse events were considered related to Cinryze.  No subject discontinued study drug due to an adverse event;  
    • There was no evid
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    SOURCE ViroPharma Incorporated
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