Navigation Links
Cinryze® (C1 Esterase Inhibitor [Human]) Data Presented at 2010 International Scientific Conference of the World Allergy Organization (WAO)
Date:12/6/2010

ylaxis of Hereditary Angioedema (HAE) Attacks,' Dr. Steven Villano, M.D., ViroPharma Incorporated, Exton, PA, presented open label data describing the efficacy profile of Cinryze in preventing attacks of HAE in 146 subjects with HAE.  Data from this study included the following:

  • Cinryze prophylaxis decreased the median angioedema attack rate from 3.0 to 0.2 attacks per month;
  • In subjects treated with Cinryze prophylaxis for more than one year, the degree of protection from HAE attacks was maintained over time;
  • With repeat administration of Cinryze, increases in antigenic and functional levels of C1 inhibitor (C1-INH) post therapy were maintained indicating no change in systemic exposure with repeated administration;
  • No anti-C1-INH antibodies were detected during this study.
  • No subjects were discontinued from Cinryze therapy due to an adverse event.  Headache, nausea, rash, erythema and diarrhea were the most frequently reported treatment-emergent Cinryze-related adverse events.

In a poster entitled, 'Open Label Use of Nanofiltered C1 Esterase Inhibitor (Human) (nf-C1 INH) for the Treatment of Hereditary Angioedema (HAE) Attacks,' Dr. Timothy Craig, M.D. of the Hershey Medical Center in Harrisburg, PA, described open label data describing the results of Cinryze in treating 609 attacks of HAE in 101 subjects with HAE.  Forty-three (43) subjects completed the study; most of those discontinuing the study did so because they transferred to the open label prophylaxis study or commercial Cinryze, or 3-month follow up was no longer required.  Data from the study included the following:

  • Unequivocal relief, defined as the presence of three consecutive 15 minute assessments consistent with improvement, occurred in 68 percent of attacks within one hour, and 87 percent within four hours;
  • Clinical relief, defin
    '/>"/>

SOURCE ViroPharma Incorporated
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. ViroPharma Receives Complete Response Letter for Cinryze™ (C1 Esterase Inhibitor [Human]) Industrial Scale Supplement
2. ViroPharma Announces Publication of Cinryze™ (C1 Esterase Inhibitor [Human]) Phase 3 Trial Results in Hereditary Angioedema (HAE) in the New England Journal of Medicine
3. ViroPharma Files Prior Approval Supplement (PAS) for Cinryze™ (C1 Esterase Inhibitor [Human]) Industrial Scale Manufacturing
4. Hereditary Angioedema Patients Report: C1-Esterase Inhibitor Concentrate Effective in Treating Acute Attacks, Helps Them Avoid Emergency Care
5. PharmAthenes Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimers Disease
6. CSL Behring Submits BLA Requesting Approval of C1-Esterase Inhibitor for the Treatment of Hereditary Angioedema
7. Protalix BioTherapeutics Extends Research Agreement With Yissum Based on Promising Acetylcholinesterase Program Results in Animal Study
8. Pharmacyclics Reports CLL Results from Preclinical and Clinical Studies of its Btk Inhibitor PCI-32765
9. Portola Pharmaceuticals Announces Data Presentations Highlighting Syk/JAK Inhibitor Clinical Development Program at 52nd American Society of Hematology Annual Meeting
10. VIDEO from Merck and Co., Inc available on thenewsmarket.com: In Phase III Study Mercks Investigational CETP Inhibitor Anacetrapib Met Safety and Efficacy Endpoints in Patients with CHD
11. Regado Biosciences, Inc. Introduces REG3, a Novel Aptamer-Based Inhibitor of Glycoprotein VI and its Matched Active Control Agent, at the American Heart Association (AHA) Scientific Sessions 2010 Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company ... Progressive Home Medical Equipment, Inc. ("Progressive") of Clarion, ... the acquisition were not disclosed. Progressive is ... wide range of sleep, mobility, and respiratory products to customers ...
(Date:1/14/2014)... Animal Emergency Critical Care, a LifeCentre partner practice, located at ... is the first in Loudoun County to ... Susan M. Barnes , Medical Director, is a well-seasoned veterinarian ... Cole Taylor , are avid scuba divers. "As altitude skiers and ...
(Date:1/14/2014)... CLEVELAND , Jan. 14, 2014 NineSigma ... will hold its Innovation Leadership Summit , May ... in Cleveland Ohio . ... innovators and organizations committed to breakthrough achievements through open ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... American National Standards Institute (ANSI) has joined ... to develop an unprecedented resource for medical device standards ... access 1,300+ medical device standards from one single database ... of Medical Instrumentation (AAMI), ASTM International, and the German ...
... , ORLANDO, Fla., Nov. 13 /PRNewswire/ Millar Instruments, ... catheters and pressure-volume (P-V) systems, and Transonic Systems, ... marketing of flow measurement devices, today announce a ... that these two giants in the field of ...
Cached Medicine Technology:New Database from ANSI, AAMI, ASTM International, and DIN Provides Centralized Source of Information for Medical Device Professionals 2New Database from ANSI, AAMI, ASTM International, and DIN Provides Centralized Source of Information for Medical Device Professionals 3Millar Instruments and Transonic Systems, Suppliers of Gold Standard Pressure and Flow Products, Enter Into Mutual Distribution Agreement 2
(Date:7/9/2014)... policing injection drug users in Russia might contribute ... A study, conducted by researchers from Boston University ... with St. Petersburg Pavlov State University, sought to ... health outcomes of a cohort of HIV-positive people ... who were arrested by police were more likely ...
(Date:7/9/2014)... in French . ... old teens, including brain structure and function, personality, life experiences ... go on to develop binge drinking within the next two ... variables such as life events and a family history of ... Whether or not the child had had a single drink ...
(Date:7/9/2014)... world have been linked to an emerging fungal ... National Institute for Mathematical and Biological Synthesis (NIMBioS) ... , In a series of mathematical models, ... of internal organs in frogs, could cause extinction ... are exposed to the virus every few years, ...
(Date:7/9/2014)... Infectious Diseases (NIAID), part of the National Institutes ... of CRS3123, an investigational oral antibiotic intended to ... ) infection. CRS3123 (previously known as REP3123) is ... while sparing normal intestinal bacteria. , The Phase ... men and women ages 18 to 45 in ...
(Date:7/9/2014)... labels handed out by pharmacists may be misread ... according to new research by the University of ... Blind)., The study, published recently in the ... prescription medications dispensed by pharmacies do not consistently ... simply following recommended guidelines for font size, use ...
Breaking Medicine News(10 mins):Health News:BU researchers relate arrests with HIV risk environment 2Health News:What drives a child to abuse alcohol? 2Health News:Study predicts ranavirus as potential new culprit in amphibian extinctions 2Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... ... free NeedyMeds iPhone app . , ... (Vocus) August 21, 2009 -- NeedyMeds, the premier source of information on programs that help ... its drug discount card. Simply by showing the pharmacist an image on their iPhones, people can ...
... , , , LOS ... Inc., announced the launch of Energy-X, a new lip balm that delivers ... or artificial sweeteners. With zero calories, Energy-X provides the energy boost consumers ... , "Energy-X is applied directly on the lips and ...
... all know that influenza vaccination helps prevent disease, but ... prevent another public health problem: inappropriate antibiotic use. The ... 1, 2009 issue of Clinical Infectious Disease , ... the Canadian province of Ontario introduced a universal immunization ...
... Increase is small but worth noting, expert says, as ... -- Smokeless tobacco increases the risk of fatal heart ... of 11 studies conducted in North America and Sweden. ... of smokeless tobacco products has increased in Europe and ...
... to list the negative stereotypes attributed to the elderly: ... What,s unsettling is that those stereotypes can be ... Research conducted by the University of Alberta,s Sheree ... stereotypes exist in some children at that age, which ...
... , WASHINGTON, Aug. 20 Congressman Chaka ... national "March for Healthcare" in Washington on September 13 to mobilize ... announced today. , , The Philadelphia Congressman, ... on colleagues in Congress to endorse the proposal for a march, ...
Cached Medicine News:Health News:iPhone App That Saves Money on Prescription Medicines 2Health News:Energy-X Lip Balm Delivers Wake-Up Call to Consumers 2Health News:Visits to Nana's may keep toddlers from developing negative age stereotypes 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: