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Cinryze® (C1 Esterase Inhibitor [Human]) Data Presented at 2010 International Scientific Conference of the World Allergy Organization (WAO)
Date:12/6/2010

ylaxis of Hereditary Angioedema (HAE) Attacks,' Dr. Steven Villano, M.D., ViroPharma Incorporated, Exton, PA, presented open label data describing the efficacy profile of Cinryze in preventing attacks of HAE in 146 subjects with HAE.  Data from this study included the following:

  • Cinryze prophylaxis decreased the median angioedema attack rate from 3.0 to 0.2 attacks per month;
  • In subjects treated with Cinryze prophylaxis for more than one year, the degree of protection from HAE attacks was maintained over time;
  • With repeat administration of Cinryze, increases in antigenic and functional levels of C1 inhibitor (C1-INH) post therapy were maintained indicating no change in systemic exposure with repeated administration;
  • No anti-C1-INH antibodies were detected during this study.
  • No subjects were discontinued from Cinryze therapy due to an adverse event.  Headache, nausea, rash, erythema and diarrhea were the most frequently reported treatment-emergent Cinryze-related adverse events.

In a poster entitled, 'Open Label Use of Nanofiltered C1 Esterase Inhibitor (Human) (nf-C1 INH) for the Treatment of Hereditary Angioedema (HAE) Attacks,' Dr. Timothy Craig, M.D. of the Hershey Medical Center in Harrisburg, PA, described open label data describing the results of Cinryze in treating 609 attacks of HAE in 101 subjects with HAE.  Forty-three (43) subjects completed the study; most of those discontinuing the study did so because they transferred to the open label prophylaxis study or commercial Cinryze, or 3-month follow up was no longer required.  Data from the study included the following:

  • Unequivocal relief, defined as the presence of three consecutive 15 minute assessments consistent with improvement, occurred in 68 percent of attacks within one hour, and 87 percent within four hours;
  • Clinical relief, defin
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SOURCE ViroPharma Incorporated
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