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Cincinnati Children's Issued Patent Covering Individualized Medication Dosing Technology
Date:12/2/2013

MASON, Ohio and CINCINNATI, Dec. 2, 2013 /PRNewswire/ -- Cincinnati Children's Hospital Medical Center (CCHMC) and Assurex Health today announced that the United States Patent and Trademark Office (USPTO) issued U.S. Patent No. 8,589,175 encompassing the "Optimization and Individualization of Medication Selection and Dosing" by Cincinnati Children's inventors Drs. Tracy A. Glauser, Richard J. Wenstrup*, Alexander A. Vinks, and John P. Pestian. The CCHMC patent covers methods for optimizing dosing regimens for medications utilizing population models, genotype, and clinical information to treat patients with neuropsychiatric and other disorders.  Assurex Health is the exclusive worldwide licensee of the technology covered under the CCHMC patent and has developed pharmacogenomic tests for psychiatric, ADHD, and pain medications commercialized under the GeneSight® brand.

The Cincinnati Children's invention provides a mechanism for translating "one size fits all" drug dosing into individualized dosing based on a person's genetic and non-heritable characteristics. The methods of the invention can be applied to correct for the variability seen in drug metabolism due to genetic polymorphisms combined with the variability resulting from non-genetic factors. The results provide a way to standardize the impact of various fixed factors, such as a patient's genetic variability, and dynamic factors, such as drug-drug and drug-environment interactions or patient drug-adherence. As a result, the starting and target doses for neuropsychiatric and other medications can be determined without the need for metabolic data.

GeneSight is a unique pharmacogenomic treatment decision support tool that tests for clinically important genetic variants affecting a patient's response to neuropsychiatric medic
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SOURCE Assurex Health
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