Navigation Links
Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients
Date:5/10/2011

.2% versus 6.1%). Patients who responded at week 12 also experienced less radiographic progression than those who did not. The majority of patients (approximately 75%) who responded at week 12 had a clinical response at week 6. These patients reported further improved outcomes such as pain, physical function and fatigue, a significantly greater response in terms of ACR20, 50 and 70 measures as well as higher rates of DAS28 LDA and remission, relative to those who showed response at week 12.

The data published were from the RAPID 1 study - a Phase III double-blind placebo-controlled trial.  The trial was designed to establish the efficacy and tolerability of certolizumab pegol together with MTX, in the treatment of moderate to severely active RA in patients who did not adequately respond to conventional treatment. The co-primary end points were ACR20 score at week 24 and change in mTSS (modified Total Sharp Score) at week 52. The post hoc analysis focused on patients who received MTX and either 200mg subcutaneously or placebo every 2 weeks for 52 weeks accounting for 393 patients in the ITT population (30 patients were excluded due to nonimputable data).  

Patients participating in the trial all met the ACR classification for RA, and had active disease at screening and an inadequate response to MTX treatment (greater than or equal to 6 months with a stable dose of greater than or equal to 10 mg weekly for greater than or equal to 2 months prior to baseline).    

For the purpose of this post hoc analysis, patients were classified as responders or non-responders based on DAS 28 > 1.2 and ACR20 response at week 6 and 12 respectively. Low disease activity was defined as DAS28 less than or equal to 3.2. Remission was defined as DAS28 less than or equal to 2.6. Improvement in disease activity, as measured by DAS28, was classified according to the EULAR response criteria.

For further Information
Scott
'/>"/>

SOURCE UCB
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Cimzia® (certolizumab pegol) Data Showed Broad and Rapid Relief From Burden of Symptoms In Rheumatoid Arthritis Patients
2. New Cimzia® (certolizumab pegol) Data Show a Significant, Rapid Clinical Response and Reduced Disease Activity Among Diverse Patient Populations With Active Rheumatoid Arthritis (RA)
3. Rapid and Long-term Clinical Responses Observed in Rheumatoid Arthritis Patients Taking Cimzia® (certolizumab pegol), According to Data Being Highlighted During ACR Meeting
4. UCB Presents Growing Body of Long-term Efficacy Data at ACG 2010 Meeting to Further Support Treatment with Cimzia® (certolizumab pegol) in Multiple Patient Populations with Moderate to Severe Crohns Disease
5. Long-Term Data on Cimzia® (certolizumab pegol) for Moderate to Severe Crohns Disease to be Highlighted at ACG Meeting
6. New Data Show CIMZIA(R) (certolizumab pegol) Provides Sustained and Significant Symptom Improvement in Moderate to Severe Crohns Patients
7. CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years
8. CIMZIA(R) (Certolizumab Pegol) Provides Long-Term Benefit Without Dose Escalation in Crohns Disease Patients
9. CIMZIA(R) (certolizumab pegol) Reduces Intestinal Lesions and Induces Endoscopic Improvement in Crohns Patients
10. CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year
11. New Subanalyses of the RE-LY Trial Showed Pradaxa Reduced Stroke Risk in Patients With Varying CHA2DS2-VASc Scores and Types of Non-Valvular Atrial Fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... LAKEWAY, Texas , July 2, 2015   ... on being the leading provider for non-invasive aesthetics in ... offer state-of-the-art tattoo removal treatments with the Astanza Duality ... transform their well being through various medical and laser ... patients with unwanted ink a clear solution to their ...
(Date:7/2/2015)... 2015   Decision Resources Group finds ... less frequent dosing as the highest unmet need ... burden on both patients and providers associated with ... injections, which are the current standard of care. ... is in development for dosing every two to ...
(Date:7/2/2015)... -- Konica Minolta, Inc. (Konica Minolta) ( Tokyo ... Technologica Ltda., an X-ray system equipment manufacturer based in ... Brazilian healthcare sales company, Konica Minolta Healthcare do ... Brazil market investment and growth With ... significant healthcare technical advancements and efficiencies are required. Aging ...
Breaking Medicine Technology:EVO Offers Advanced Laser Tattoo Removal With Astanza Duality In Lakeway, TX 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 3Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 2Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 3
... NeoStem, Inc. (NYSE Amex: NBS ), an ... announced today that Dr. Ian Zhang, PhD, MBA, President and ... Rodman & Renshaw Annual China Investment Conference on Tuesday, March ... 8, 2011, is being held at Le Royal Meridien Shanghai, ...
... Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX ) announced ... Roth 23rd Annual Growth Stock Conference on Monday, March 14, ... Niguel in Dana Point, California and at the Barclays Capital ... 11:15 a.m. ET at the Loews Miami Hotel, Florida. ...
Cached Medicine Technology:NeoStem To Present at Rodman & Renshaw Annual China Investment Conference on Tuesday, March 8 2NeoStem To Present at Rodman & Renshaw Annual China Investment Conference on Tuesday, March 8 3NeoStem To Present at Rodman & Renshaw Annual China Investment Conference on Tuesday, March 8 4
(Date:7/3/2015)... ... 03, 2015 , ... Jennifer Renee Hanes, DO is the new Medical Director ... network of independent freestanding emergency rooms in the United States. , “We are excited ... facility,” said Executive Medical Director of First Choice Emergency Room, Dr. James M. Muzzarelli. ...
(Date:7/3/2015)... , ... July 03, 2015 , ... " Selfie on ... which features the latest and coolest technology products available to consumers. Amanda Forstrom, a ... how these selfie sticks are great for documenting memories. , Almost every smartphone has ...
(Date:7/3/2015)... ... 2015 , ... Every year, One-to-1 Fitness and the Red Deer Fit ... Red Deer community with free fitness training and indoor fitness boot camp classes for ... entertainment raised thousands of charity dollars and ended with a $10,000 donation to the ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... the first sweetFrog store located in Mississippi. The premium frozen yogurt chain was listed ... The store, located at 104 Railroad Avenue, New Albany, MS 38652, will have a ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... the 19th sweetFrog store located in the Lone Star State. The premium frozen yogurt ... in 2014. , The store, which opened July 1 at Duke’s Travel Plaza, is ...
Breaking Medicine News(10 mins):Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2
... With health care fraud,becoming more organized, sophisticated, ... insurance Special Investigative Units,(SIUs), state and federal ... the National Health Care Anti-Fraud Association (NHCAA),s ... California, to learn,more about new fraud schemes ...
... COEUR D,ALENE, Idaho, Nov. 15 NightHawk,Radiology ... provider of services,to radiology groups across the United ... full range of services, an industry first, at ... (North Building,- Hall B: 8551) in Chicago, November ...
... individuals with metastatic melanoma (MM) is not good. Therapeutic ... benefit; however, most patients eventually succumb to progressive disease, ... cells (DCs) fail to sustain an effective antitumor T ... human melanoma cell lines and resected tumors by Norman ...
... million Americans live in nursing homes today. By 2020, ... in a nursing home, assisted living facility, chronic care ... At this time of skyrocketing demand for long-term care, ... a major grant to create the first research database ...
... to improve radiologist productivity, service, and quality, ... AMCS ),a leader in radiology and medical image ... feature RadStream(TM), a next,generation software product designed to ... with, communicating critical results to,referring physicians, at the ...
... Ala., Nov. 15 BioHorizons Implant Systems,Inc. has ... that feature a,unique thread design and proven surface ... BioHorizons to address the tapered,market segment which account ... The Tapered Internal Implants incorporate the Laser-Lok(R) ...
Cached Medicine News:Health News:NHCAA Annual Training Conference Bringing Together Law Enforcement, Health Insurers to Fight Health Care Fraud 2Health News:NHCAA Annual Training Conference Bringing Together Law Enforcement, Health Insurers to Fight Health Care Fraud 3Health News:NightHawk Radiology: One Source, One Solution 2Health News:NightHawk Radiology: One Source, One Solution 3Health News:NightHawk Radiology: One Source, One Solution 4Health News:Brown to create most comprehensive long-term care database 2Health News:Brown to create most comprehensive long-term care database 3Health News:AMICAS Transforms Critical Results Notification with RadStream 2Health News:AMICAS Transforms Critical Results Notification with RadStream 3Health News:BioHorizons Introduces Its New Tapered Internal Implants Featuring Laser-Lok(R) Microgrooves 2
... Unique product designed for LASIK surgery ... Designed to irrigate the corneal interface ... easy insertion under the flap and ... ports provide multi-directional irrigation.27G x 7/8in ...
... product designed for LASIK surgery and other ... the corneal interface and/or stromal bed. Flattened ... and helps elevate the flap edge. Multiple ... (.40 x 22mm) Formed 9mm from end ...
For injecting viscoelastic to all meridians of the anterior chamber and to coat intraocular lenses. 20G x 7.8in (.90 x 22mm)....
For administering anesthetic agents into the posterior sub-Tenon's space 20G x 1in (.90 x 25mm)...
Medicine Products: