Navigation Links
Cimzia® (certolizumab pegol) Data Showed Broad and Rapid Relief From Burden of Symptoms In Rheumatoid Arthritis Patients
Date:5/10/2011

eled portions of certolizumab pegol studies of Crohn's disease and other diseases, malignancies (excluding non-melanoma skin cancer) were observed at a rate of 0.5 per 100 patient-years among 4,650 certolizumab pegol-treated patients versus a rate of 0.6 per 100 patient-years among 1,319 placebo-treated patients.  In studies of certolizumab pegol for Crohn's disease and other investigational uses, there was one case of lymphoma among 2,657 certolizumab pegol-treated patients and one case of Hodgkin lymphoma among 1,319 placebo-treated patients.  In certolizumab pegol RA clinical trials (placebo-controlled and open label) a total of three cases of lymphoma were observed among 2,367 patients.  This is approximately 2-fold higher than expected in the general population.  Patients with RA, particularly those with highly active disease, are at a higher risk for the development of lymphoma.  The potential role of TNF blocker therapy in the development of malignancies is not known.

Malignancies, some fatal, have been reported among children, adolescents, and young adults who received treatment with TNF-blocking agents (initiation of therapy less than or equal to 18 years of age), of which certolizumab pegol is a member.  Approximately half of the cases were lymphoma (including Hodgkin's and non-Hodgkin's lymphoma), while the other cases represented a variety of different malignancies and included rare malignancies associated with immunosuppression and malignancies not usually observed in children and adolescents.  Most of the patients were receiving concomitant immunosuppressants.

Cases of acute and chronic leukemia have been reported with TNF-blocker use.  Even in the absence of TNF-blocker therapy, patients with RA may be at a higher risk (approximately 2-fold) than the general population for developing leukemia.

Heart Failure

Cases of worsening congestive heart failur
'/>"/>

SOURCE UCB
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. New Cimzia® (certolizumab pegol) Data Show a Significant, Rapid Clinical Response and Reduced Disease Activity Among Diverse Patient Populations With Active Rheumatoid Arthritis (RA)
2. Rapid and Long-term Clinical Responses Observed in Rheumatoid Arthritis Patients Taking Cimzia® (certolizumab pegol), According to Data Being Highlighted During ACR Meeting
3. UCB Presents Growing Body of Long-term Efficacy Data at ACG 2010 Meeting to Further Support Treatment with Cimzia® (certolizumab pegol) in Multiple Patient Populations with Moderate to Severe Crohns Disease
4. Long-Term Data on Cimzia® (certolizumab pegol) for Moderate to Severe Crohns Disease to be Highlighted at ACG Meeting
5. New Data Show CIMZIA(R) (certolizumab pegol) Provides Sustained and Significant Symptom Improvement in Moderate to Severe Crohns Patients
6. CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years
7. CIMZIA(R) (Certolizumab Pegol) Provides Long-Term Benefit Without Dose Escalation in Crohns Disease Patients
8. CIMZIA(R) (certolizumab pegol) Reduces Intestinal Lesions and Induces Endoscopic Improvement in Crohns Patients
9. CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year
10. New Subanalyses of the RE-LY Trial Showed Pradaxa Reduced Stroke Risk in Patients With Varying CHA2DS2-VASc Scores and Types of Non-Valvular Atrial Fibrillation
11. Prolia® (denosumab) Open-Label Extension Trial Showed Continued Increase in Bone Mineral Density Over Five Years of Treatment With Similar Safety Profile Observed in Pivotal Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... , Oct. 31, 2014 ThynkWare ( ... (ALS) patients initiate text and email messages using their ... patent-pending technology invented by ThynkWare,s founder, Duane Cash ... a smartphone device. This technology allows users to control ... the power of thought. ThynkWare provides the ...
(Date:10/31/2014)... /CNW Telbec/ - Ergoresearch Ltd ("Ergoresearch" or ... accelerated growth in terms of sales and profitability. Annual ... Net income amounted to $1,230,153. The EBITDA reached $3,087,816, ... in the Company,s history. With the goal ... of its subsidiaries, merging in September 2014 Clinique du ...
(Date:10/31/2014)... 31, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... , Isis Pharmaceuticals, Third Quarter 2014 Financial Results ... at 11:30 a.m. ET / 8:30 a.m. PTWhere: ... Internet. Simply log onto our website listed above. If ... a replay of the webcast will be available for ...
Breaking Medicine Technology:ThynkWare Speech Helps Those with ALS and Locked-In Syndrome Translate Thought to Speech on Their Smartphone Devices 2Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 2Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 3Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 4Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 5Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 3
... 2012  In a single bound, Nepean Cancer Care Centre ... its prostate cancer cases to a dramatically faster therapy ... technique that is even quicker with Elekta,s new Integrity™ ... their first patient with prostate cancer using Integrity on ...
... CSL Behring is the recipient of ... developing and manufacturing therapies used to treat rare and ... in plasma-derived and recombinant therapies used to treat congenital ... disease, is a subsidiary of CSL Limited ...
Cached Medicine Technology:Australian Clinic Puts Prostate Cancer Radiation Therapy on Fast Track With Elekta VMAT and Integrity Digital Control System 2Australian Clinic Puts Prostate Cancer Radiation Therapy on Fast Track With Elekta VMAT and Integrity Digital Control System 3CSL Behring Recognized as a "Pioneer" By European Organisation for Rare Diseases (EURORDIS) 2
(Date:10/31/2014)... St. Joseph, Missouri (PRWEB) October 31, 2014 ... prepare for school, one Midwest optometrist feels they may ... vision problems to affect areas like concentration, school performance ... events may be too brief to identify progressive vision ... Options, St. Joseph, Mo., announces a new initiative: The ...
(Date:10/31/2014)... Oct. 31, 2014 (HealthDay News) -- Obesity increases the ... black and Hispanic women, two new U.S. studies show. ... found being overweight or obese increased the risk for ... women. "We,ve known this for a long time ... also in Hispanic women," study author Esther John, a ...
(Date:10/31/2014)... Santa Barbara, CA (PRWEB) October 31, 2014 ... for holiday shoppers to find affordable but tasteful gifts for ... special 22nd Annual Early Bird Gift Giving Special , ... percent off when they purchase Wine Club Gift membership. ... to take advantage of this special. Besides offering discounts, Gold ...
(Date:10/31/2014)... 2014 Florida Air Academy, the ... in grades 6-12, is taking the lead when ... and concussions, becoming the first high school in ... Post-Concussion Assessment and Cognitive Testing) computerized assessment to ... lawsuit grabs the headlines, and the Centers for ...
(Date:10/31/2014)... 31, 2014 BCC Research ( http://www.bccresearch.com ) ... QUALITY MARKET , the U.S. indoor air quality (IAQ) market ... a compound annual growth rate (CAGR) of 7% over the ... grow at a CAGR of 7.4%. , Since 2012, ... mold, the outbreak of infectious diseases such as bird flu ...
Breaking Medicine News(10 mins):Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Study Confirms Obesity-Breast Cancer Link for Blacks, Hispanics 2Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2Health News:Florida Air Academy Tackling Concussions Head-On 2Health News:Florida Air Academy Tackling Concussions Head-On 3Health News:Global Market for U.S. Indoor Air Quality (IAQ) to Reach $11.4 Billion by 2019; Equipment Market Segment Surging at 7.4% CAGR 2Health News:Global Market for U.S. Indoor Air Quality (IAQ) to Reach $11.4 Billion by 2019; Equipment Market Segment Surging at 7.4% CAGR 3
... , FRIDAY, Jan. 14 (HealthDay News) -- Obese ... doctors than obese white patients, a new study finds. ... Public Health also said they were surprised to find that ... to receive weight and exercise counseling than black patients treated ...
... A simple, automated method of tracking E. coli ... potentially contaminated bodies of water or waterways. The technique described ... and Drug Design could reduce the incidence of waterborne ... environmental and health problem. Water related diseases are the leading ...
... COLUMBUS, Ohio A new study by Ohio State ... cancer by combining two kinds of targeted agents, one ... and one that reverses changes that silence genes that ... available and being evaluated individually in clinical trials, the ...
... THURSDAY, Jan. 13 (HealthDay News) -- Home-based dialysis is an ... say. In a new study, researchers evaluated the impact ... the survival of 2,110 adult Canadian patients who had to ... were similar for both groups of patients during the initial ...
... Association today issued a call to action for the public, ... efforts to reduce the amount of sodium (salt) Americans consume ... Journal of the American Heart Association , the association sets ... the general population, which is to consume no more than ...
... , THURSDAY, Jan. 13 (HealthDay News) -- In an unscripted ... Tucson and America" memorial, President Barack Obama said Rep. Gabrielle ... and her husband Mark Kelly at University Medical Center in ... to House Minority Leader Nancy Pelosi (D-Calif.) confirmed that Pelosi, ...
Cached Medicine News:Health News:Is Race a Factor in Obesity Counseling? 2Health News:Speeding up E. coli detection 2Health News:Study provides molecular rationale for combining targeted agents to treat breast cancer 2Health News:Dialysis Options Remain After Kidney Transplant Failure 2Health News:Population-wide reduction in salt consumption recommended 2Health News:Population-wide reduction in salt consumption recommended 3Health News:Giffords Opens Eyes. Like 'Watching a Miracle,' Friends Say 2Health News:Giffords Opens Eyes. Like 'Watching a Miracle,' Friends Say 3
The Panorama Central Station includes bi-directional communication with Datascope bedside monitors, optional 72 hours of disclosure and a touch screen user interface....
... The MedSystem III DLE (Drug List ... dimension to drug infusion technology. The instrument ... features and clinical versatility in an unparalleled ... Calculation, the MedSystem III Infusion System simplifies ...
... One of the first steps any ... to offer the most powerful, most effective ... Acute Care, CliniComps world-class clinician documentation and ... and health systems achieve this goal. In ...
... Essentris Critical Care, the world-class clinician ... reflects decades of focus on the specific ... critical care environments. Its broad, deep clinical ... leading documentation and EMR solution in critical ...
Medicine Products: