Navigation Links
Christiana Care Health System Leads National Colorectal Cancer Clinical Trial
Date:3/24/2011

WILMINGTON, Del., March 24, 2011 /PRNewswire-USNewswire/ -- Christiana Care Health System's Helen F. Graham Cancer Center is leading a national clinical trial to determine if Crestor® (Rosuvastatin), a cholesterol-lowering drug, can prevent new colon tumors from forming after colon cancer surgery.

(Logo: http://photos.prnewswire.com/prnh/20090407/DC95299LOGO)

The study seeks to determine if Crestor can stop the growth of tumor cells by blocking some of the enzymes that affect cell growth. The trial will also determine if Crestor can keep new  colon tumors from forming after surgery to remove a patient's initial colon cancer.

The study, entitled, "P-5: Statin Polyp Prevention Trial in Patients with Resected Colon Cancer," is conducted under the auspices of the National Cancer Institute by a network of cancer research professionals, the National Surgical Adjuvant Breast and Bowel Project (NSABP). It takes place at more than 200 medical centers throughout North America.

"Previous epidemiological studies looking back at patient data associated with statin use indicate these drugs lower the risk of colorectal cancer, but the evidence remains controversial," says Bruce Boman, M.D., Ph.D., study protocol chair. "Earlier studies were designed to investigate lipid-lowering or cardiovascular endpoints over the short-term rather than tumor development in the long run."

Dr. Boman is director of Cancer Genetics at the Helen F. Graham Cancer Center's Hereditary Cancer Risk Assessment Program. He is also a scientist at the Center for Translational Cancer Research who investigates how cancer stem cells drive tumor growth.

The study aims to recruit 1,740 patients who have recently been diagnosed with early stage colon cancer and who were not already taking statins for high cholesterol. Patients will be randomly assigned to one of two groups. Each group will take one pill a day for five years. One group will receive Rosuvastatin, the other a placebo.

Investigators also will look at participants with a family history of colorectal cancer and those who take a daily low or high dose of aspirin. Previous studies indicate non-steroidal anti-inflammatory drugs, including aspirin, and statin drugs, like Crestor, work together. Further evidence of this relationship could support reducing doses to improve the risk and benefits of these two types of drugs.

People recently diagnosed with a Stage I or II colon cancer and interested in the study can call the Helen F. Graham Cancer Center's Research Office at 302-623-4550. A list of other participating sites is at the trial website.

Available Topic Expert(s): For information on the listed expert(s), click appropriate link.

Nicholas Petrelli

https://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=88807


'/>"/>
SOURCE Christiana Care Health System
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. AstraZeneca Donates $1 Million for Christiana Care Health Systems Wilmington Hospital Project
2. Christiana Care Health System Rolls Out Electronic Computerized Provider Order Entry
3. American Imaging Management Promotes Affordability and Choice to Health Care Consumers
4. The Procter & Gamble Company and Teva Pharmaceutical Industries Form Consumer Health Care Partnership
5. Leading Hospitals Committed to Healthcares Adoption of GS1 Standards Use Omnicell Solutions for Supply Chain Management
6. CVS/pharmacy Debuts the "To Your Health" Program in Los Angeles Bringing 240 Free Health Screening Events to the Community
7. New Nationwide Survey Identifies Need for Increased Dialogue Between Gastroesophageal Reflux Disease or Frequent Heartburn Sufferers and Health Care Providers
8. Telome Health, Inc. Launches With Exclusive IP Portfolio
9. Quest Diagnostics Launches National Electronic Health Records Awareness Tour Showcasing Care360 EHR
10. Prognosis Health Information Systems Expands Executive Team
11. International Medical Corps Team in Hardest-Hit Coastal Communities Finds Severe Shortages of Food, Water, Medicines; Acute Need for Mental Health Support
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... DUBLIN , Dec 8, 2016 Research and Markets ... Report" report to their offering. ... This report analyzes the worldwide markets for ... US, Canada , Japan , ... , and Rest of World. Annual estimates and forecasts are provided ...
(Date:12/8/2016)... 2016 Bodycad announced it has been ... accuracy, reproducibility and speed for 3D constructs via ... bone orthopaedic applications. These patents are critical to ... restorations based on each patient,s distinct anatomy. ... harnesses the world,s first suite of orthopaedic CAD/CAM ...
(Date:12/8/2016)... , Dec. 8, 2016 True Health ... brings leading-edge laboratory services and management expertise to ... , allowing more doctors and patients to ... management solutions. Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... Hospital systems, under pressure to contain costs, have ...
Breaking Medicine Technology:
(Date:12/9/2016)... ... December 09, 2016 , ... ... pharmaceutical inserts and outserts. As a means of expanding capabilities Flottman has ... enable Flottman to individually code professional inserts (PIs) and patient package inserts (PPIs) ...
(Date:12/9/2016)... York, NY (PRWEB) , ... December 09, 2016 , ... ... raises awareness for organ transplantation while encouraging readers to sign up as an organ ... a lifesaving organ transplant. , An organ donor can save up to 8 ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... will become Quality Insights beginning January 1, 2017. The name change aligns ... commitment to measuring and improving health care quality. , “We are very proud ...
(Date:12/8/2016)... Pa. (PRWEB) , ... December 08, 2016 , ... ... Medicine Southern Chester County, a Property owned by an affiliate of Seavest, has ... square foot Penn Medicine Southern Chester County ambulatory care center (ACC) was named ...
(Date:12/8/2016)... ... December 08, 2016 , ... Premier Fitness Camp (PFC) and The ... ultimate weight loss and wellness program, at their world headquarters of Omni La Costa ... and long-term results to anyone seeking weight loss, personal development, a healthy lifestyle, or ...
Breaking Medicine News(10 mins):