Navigation Links
Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer
Date:10/23/2008

HDACs appear to promote tighter winding of DNA around these proteins, leading to reduced access by gene transcription factors. This results in decreased expression of proteins involved in cell differentiation, cell cycle arrest and apoptotic elimination of damaged cells -- all of which contribute to the development of cancer. HDAC inhibitors are able to restore expression of tumor suppressor genes in a highly selective manner. Treatment with HDAC inhibitors also leads, indirectly, to inhibition of the expression of angiogenesis factors, helping to choke off the blood supply to tumors.

Although significant preclinical and clinical activity has been observed with HDAC inhibitors, most have characteristics which may limit their potential for clinical success or broad applicability. In contrast, Chidamide/HBI-8000 has selectivity, potency, PK and side effect profiles that make it ideal for use as a stand-alone therapeutic, as well as in combination with a wide variety of marketed anti-tumor agents.

HUYA's Integrated Co-development Model (ICM)

The global pharmaceutical industry faces a pressing need for new untapped sources of pre-clinical and clinical stage compounds for the drug development process. HUYA was one of the first companies to recognize China's potential to help meet this need through its burgeoning biotechnology industry and world-class talent pool. HUYA has pioneered an innovative approach -- the HUYA Integrated Co-development Model -- for partnering with Chinese research institutions and pharmaceutical companies. HUYA identifies and licenses the most promising pre-clinical and clinical stage compounds in China, leverages and extends the research efforts of its Chinese partners, and provides a bridge into the Western development process and biopharma market.

Because the compounds have already been validated through a rigorous discovery, selection and development process in China, this model streamlines and accelerates developmen
'/>"/>

SOURCE HUYA Bioscience International; Chipscreen Biosciences
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
2. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
3. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases
4. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
5. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
6. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
7. Alacrity Biosciences Announces Positive Results from a Phase 2 Study of Its Dry Eye Treatment ALTY-0501
8. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
9. Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System
10. Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions
11. Regado Biosciences Presents Early Stage Clinical Data for REG1 Anticoagulation System at American Heart Association 2007 Scientific Sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 21, 2015  Inmark,s acquisition of Saf-T-Pak last ... Goods Training, specifically Division 6.2.  For over 25 ... training programs focusing on IATA, ICAO, US DOT, ... "We were particularly interested in Saf-T-Pak,s ... multilingual internet training programs," said David Oyler ...
(Date:4/21/2015)... 21, 2015 Global cap & ... demand for caps and closures will exceed $55 billion in ... two trillion annually. Beverages will continue to account for well ... a number of smaller markets are expected to register faster ... Although the most developed markets -- the US, ...
(Date:4/21/2015)... 21, 2015 The global dermatology diagnostic devices ... 8.2% from 2014 to 2019. North America ... larger shares in the global dermatology diagnostic devices market. ... is mainly attributed to a wide range of factors, ... of dermatologists, and technological advancements made in the field ...
Breaking Medicine Technology:Inmark's Acquisition Of Saf-T-Pak Results In Expansion Of Its Dangerous Goods Training Portfolio 2World Caps & Closures Market 2World Caps & Closures Market 3Dermatology Diagnostic Devices Market by Product, by End-User - Global Forecast to 2019 2Dermatology Diagnostic Devices Market by Product, by End-User - Global Forecast to 2019 3
(Date:4/21/2015)... April 21, 2015 The California ... 275 leading life sciences organizations, released the following ... regarding California State Assembly Bill (AB) 463: , ... to the development of treatments and cures for ... deep concerns regarding AB 463, the so-called Pharmaceutical ...
(Date:4/21/2015)... NJ (PRWEB) April 21, 2015 ... across platforms and devices, today announced a new enhancement ... of the new Microsoft Office 365 Management Activity API. ... customers to fully audit and take action on all ... , “The new Office 365 Management Activity API provides ...
(Date:4/21/2015)... released a new blog post explaining how to find ... are large vehicles that fare well in crash tests. A ... car shows that passengers from the first car have a ... but these large vehicles may be unstable and they may ... possible to find low cost car insurance plans on a ...
(Date:4/21/2015)... Carinsurancehints.com has released a new blog post presenting heavily ... auto insurance prices . , Commuting on heavy ... review their insurance options before deciding what plan to ... Some of the popular policies provide liability, collision or ... and find the best prices in their area simply ...
(Date:4/21/2015)... Respected academic institution selects Visage 7 for ... Imaging Inc. (“Visage”), a wholly owned subsidiary of Pro ... contract with University of Florida Health — a large ... furthers the penetration of Visage 7 technology ... the North American enterprise imaging market. Visage 7 ...
Breaking Medicine News(10 mins):Health News:California Healthcare Institute Statement on AB 463 2Health News:California Healthcare Institute Statement on AB 463 3Health News:AvePoint Integrates Microsoft Office 365 Management Activity API into DocAve Policy Enforcer for Proactive SharePoint Monitoring 2Health News:AvePoint Integrates Microsoft Office 365 Management Activity API into DocAve Policy Enforcer for Proactive SharePoint Monitoring 3Health News:Auto Insurance Quotes For SUVs Are Available Online 2Health News:Heavily Circulated Roads Can increase Auto Insurance Costs 2Health News:Visage Imaging Signs University of Florida Health 2Health News:Visage Imaging Signs University of Florida Health 3Health News:Visage Imaging Signs University of Florida Health 4
... , The New Pharmacy Benefit Evaluator Analyzes Health Plan ... Inform Managed Care Sales Strategy Development , , ... of managed care market intelligence, has enhanced its ... that analyzes health plan pharmacy benefit structure and spending ...
... campaign finance watchdog group , , WASHINGTON, ... million to influence Congress and Administrations over the last ten ... last two decades, according to a Public Campaign Action Fund ... , , "When President Obama addresses the AMA today, ...
... Sciences Centre (LHSC) working in collaboration with researchers at ... has joined 16 other world-class centres to form HEARRING ... of Excellence. These centres, which are leaders within ... "cluster". This will allow members to set scientific and ...
... anti-inflammatory drugs might protect people struggling with dementia from ... release of a study of human brain tissue in ... Brain Institute of the University of Florida, in collaboration ... that inflammation of microglia an abundant cell type ...
... Sixty-four survivors of medical malpractice from 21 states sent ... the rights of medical malpractice victims have become a "political ... care plan, and that their rights may be stripped away ... supports measures that would drastically limit injured patients, rights to ...
... Six of the world,s foremost health agencies, collectively ... research funding, today announced formation of a landmark ... chronic, non-communicable diseases: cardiovascular diseases (mainly heart disease ... type 2 diabetes. , The health impact ...
Cached Medicine News:Health News:HealthLeaders-InterStudy Launches Pharmacy Benefit Evaluator 2Health News:Backgrounder: As Obama Makes Pitch to AMA, the Group Tries to Call in its Political Investment in Congress 2Health News:Popular Alzheimer's theory may be false trail 2Health News:Popular Alzheimer's theory may be false trail 3Health News:Medical Malpractice Survivors Decry Possible Stripping of Rights in President's Health Care Plan 2Health News:Health research agencies form global alliance to curb humanity's most fatal diseases 2
Easy to use practice management software....
... Practice Management software- ... system of Software, Support, ... offices of Optometry, Ophthalmology, ... streamlines office operations, allowing ...
... hematology system delivers a full ... for speed and accuracy, this ... with impressive productivity. The Advia ... its own or twinned with ...
The XT-1800i is a compact, high performance, automated hematology analyzer that provides accurate and precise CBC result including a fully automated WBC 5-part differential, and comprehensive test re...
Medicine Products: