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Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer
Date:10/23/2008

First Compound Sourced from China Shows Strong Results Presented at

Cambridge Healthtech Institute Fall Conference

BOSTON, Oct. 23 /PRNewswire/ -- CHI -- Chipscreen Biosciences (Chipscreen) and HUYA Bioscience International (HUYA) today described the preclinical profile and outcome of a Phase I trial with Chidamide/HBI-8000, carried out in China by Chipscreen Biosciences, Ltd. of Shenzhen. The clinical trial produced best in class pharmacokinetics (PK), biomarker and safety profiles, and demonstrated activity against T-lymphoma and other tumor types.

The compound, known as Chidamide in China and HBI-8000 in the US, is a novel, benzamide class histone deacetylase (HDAC) inhibitor discovered by Chipscreen using a computer-aided rationale design approach. Chidamide/HBI-8000 shows promise for the treatment of a broad range of cancers. The Phase I trial, which was initiated in China in April 2007, evaluated safety, PK, biomarker and efficacy profiles in relapsed/refractory solid tumors and lymphomas.

"The preclinical data, generated in both China and the US, as well as the Phase I results are very promising -- demonstrating a best in class profile," said Mireille Gingras, PhD, CEO, HUYA Bioscience International. "The data will enable advancement of Chidamide/HBI-8000 to Phase II/III studies in China and Phase I in the US, and provides significant validation of our China/US co-development business model."

"With this exciting data in humans and continuing research efforts in our laboratory, we are also starting to understand better the unique properties and novel molecular mechanisms of action potentially associated with Chidamide as well as certain subtypes of the HDAC family," said Xian-Ping LU, PhD, President and Chief Scientific Officer of Chipscreen Biosciences.

HUYA holds exclusive development and commercialization rights to the compound worldwide outside of China, while Chipscreen maintains rights in China.
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SOURCE HUYA Bioscience International; Chipscreen Biosciences
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