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Chimerix's Broad Spectrum Antiviral Therapeutic, CMX001, Demonstrates Potential To Mitigate BK Virus Associated End-Organ Disease In Clinical Study
Date:7/23/2012

RESEARCH TRIANGLE PARK, N.C., July 23, 2012 /PRNewswire/ -- Chimerix, Inc., a biotechnology company developing orally-available antiviral therapeutics, today announced the presentation of data showing that its lead antiviral compound, CMX001, has the potential to reduce end-organ damage associated with BK virus (BKV) in hematopoietic stem cell transplant (HSCT) recipients.  This new retrospective analysis, entitled "CMX001, a Novel Broad Spectrum Antiviral, May Mitigate Signs of BK Virus (BKV) Associated Bladder and Kidney End-Organ Damage," was presented at the 24th International Congress of the Transplantation Society in Berlin, Germany.

BKV infection is commonly observed post solid organ transplant (SOT) and is associated with renal dysfunction and potential kidney graft loss.  BKV is also known to cause hemorrhagic cystitis (a painful inflammatory bladder condition) in HSCT recipients, but the incidence and impact of BKV infection on bladder or kidney dysfunction in this patient population have been less well characterized.  Herve Mommeja-Marin, MD, Vice President of Clinical Research at Chimerix, presented the BKV data from the Phase 2 Study CMX001-201, which had as its primary objective the evaluation of CMX001 versus placebo for the prevention of cytomegalovirus (CMV) infection in 230 HSCT recipients.  Phase 2 results presented elsewhere have shown that CMX001, at various doses, was active and well-tolerated in the prevention of CMV infection or disease.   

The observations from Study 201 represent the largest retrospective analysis of BKV-associated signs and symptoms collected in a randomized, placebo-controlled trial reported to date.  In Study 201, which evaluated only HSCT recipients, there was a high incidence of BKV infection: BKV was measurable in the urine samples of 55% (126/230) of subjects at some time during the study period.  Of these subjects, 80% (101/126) were positive
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SOURCE Chimerix, Inc.
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