Navigation Links
Chimerix's Broad Spectrum Antiviral Therapeutic, CMX001, Demonstrates Potential To Mitigate BK Virus Associated End-Organ Disease In Clinical Study
Date:7/23/2012

RESEARCH TRIANGLE PARK, N.C., July 23, 2012 /PRNewswire/ -- Chimerix, Inc., a biotechnology company developing orally-available antiviral therapeutics, today announced the presentation of data showing that its lead antiviral compound, CMX001, has the potential to reduce end-organ damage associated with BK virus (BKV) in hematopoietic stem cell transplant (HSCT) recipients.  This new retrospective analysis, entitled "CMX001, a Novel Broad Spectrum Antiviral, May Mitigate Signs of BK Virus (BKV) Associated Bladder and Kidney End-Organ Damage," was presented at the 24th International Congress of the Transplantation Society in Berlin, Germany.

BKV infection is commonly observed post solid organ transplant (SOT) and is associated with renal dysfunction and potential kidney graft loss.  BKV is also known to cause hemorrhagic cystitis (a painful inflammatory bladder condition) in HSCT recipients, but the incidence and impact of BKV infection on bladder or kidney dysfunction in this patient population have been less well characterized.  Herve Mommeja-Marin, MD, Vice President of Clinical Research at Chimerix, presented the BKV data from the Phase 2 Study CMX001-201, which had as its primary objective the evaluation of CMX001 versus placebo for the prevention of cytomegalovirus (CMV) infection in 230 HSCT recipients.  Phase 2 results presented elsewhere have shown that CMX001, at various doses, was active and well-tolerated in the prevention of CMV infection or disease.   

The observations from Study 201 represent the largest retrospective analysis of BKV-associated signs and symptoms collected in a randomized, placebo-controlled trial reported to date.  In Study 201, which evaluated only HSCT recipients, there was a high incidence of BKV infection: BKV was measurable in the urine samples of 55% (126/230) of subjects at some time during the study period.  Of these subjects, 80% (101/126) were positive
'/>"/>

SOURCE Chimerix, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. The Biomedical Device Industry in America: Challenges at Home and Abroad
2. Polish Medicine Attracts Patients From Abroad - Not Only During EURO 2012
3. Effie Toshav Joins Fenwick - Broadens Life Sciences Service Platform
4. Broad Patent Protection Granted for iBio Immunomodulator
5. Netsmarts Focus on Innovation to Help Health and Human Service Providers Span the Spectrum of Care in the Healthcare 3.0 Environment
6. Generics in the Antivirals Market to 2018 - Launch of Generic Combivir and Patent Expiry of Sustiva, Kaletra and Epivir-HBV will Drive Volume Growth
7. Study Results Demonstrate Analytical Treatment Interruption to Assess Antiviral Activity of Argoss Arcelis™ Personalized Immunotherapy for Treatment of HIV Patients, AGS-004, Is Acceptable Strategy for At Least 16 Weeks
8. Cancer Cell Article Demonstrates First Definitive Evidence for Targeting of Pol I as New Approach to Cancer Therapy
9. LIVE VIA SATELLITE: Physician Demonstrates New Medical Technology to Combat Back Pain without Major Surgery
10. Six-Year Follow-Up Data for SPRYCEL®? (dasatinib) 100 mg Once Daily Demonstrates 71 Percent Overall Survival in Patients with Chronic-Phase Chronic Myeloid Leukaemia Resistant or Intolerant to Imatinib
11. Polaris Group Lead Therapeutic Candidate ADI-PEG 20 Demonstrates Potential Anticancer Activity in Various Metastatic Sarcomas and Bladder Cancers That Are Deficient in Key Metabolic Protein, and Enhanced Effects with Combination Therapy in Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)...  El Camino Hospital, a leader in the use ... Leaf Patient Monitoring system to help prevent hospital-acquired pressure ... susceptible to bed sores. The decision was ... the system, which showed dramatic improvement in compliance with ... the one of the most effect ways to prevent ...
(Date:7/30/2014)... PITTSBURGH , July 30, 2014   ... Markets Groups Inc.: OTC Pink: UPZS), a Delaware ... a distribution agreement with Larasan Pharmaceutical Corporation ("Larasan"), a ... products.  According to the agreement, US-based Larasan will ... gourmet 6" frozen pizza through Larasan,s vast distribution ...
(Date:7/30/2014)... SANTA CLARA, Calif. , July 30, 2014 /PRNewswire/ ... innovation economy, released a study today that ... venture-backed biopharma and medical device companies.  According to the ... healthcare saw the biggest potential returns since SVB started ... the year of the IPO.  Built on solid healthcare ...
Breaking Medicine Technology:El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3
...  IRIDEX Corporation (Nasdaq: IRIX ) announced ... of IRIDEX, MicroPulse laser therapy.  The study examined ... central serous chorioretinopathy (CSC).(1) The study concluded tissue-sparing ... for CSC, also known as CSR, an eye ...
... Texas, Jan. 25, 2012 UNT Health Science Center ... Myron (Mike) Jacobson, Ph.D., as the founding dean of ... search we were very pleased to recruit a renowned ... academic leader in pharmacy education, and a successful entrepreneur ...
Cached Medicine Technology:IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 2IRIDEX MicroPulse™ Laser Therapy Enhances Visual Function in Patients with Central Serous Chorioretinopathy (CSC) 3UNT System Names Jacobson Founding Dean of College of Pharmacy 2UNT System Names Jacobson Founding Dean of College of Pharmacy 3
(Date:7/31/2014)... 2014 FORT LAUDERDALE, FLORIDA – ... leading US Joint Commission Accredited teleradiology and telemedicine ... technologically advanced consumer storage and sharing platform for ... providing valued members the use of its Cloud-based ... already offered by SecondOpinions.com®. , Wide-spread radiologic ...
(Date:7/31/2014)... Lauderale, FL (PRWEB) July 31, 2014 ... accepting referrals of insurance patients seeking massage therapy in ... company provides an option for Licensed Massage Therapists who ... refer these patients to BWT. Should a patient request ... the referral, BWT can then contract the therapist to ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 What’s ... practice provider? Community Health Center of Snohomish answers ... Pediatricians vs. Family Doctors ”. Many adults can ... available to them. Community Health Center hopes to ... and differences between the two. , To ...
(Date:7/31/2014)... When it comes to aesthetics and wellness, ... As such, Natalie Sharp's Pure Vitality Rx ... new, more focused direction and to provide the latest ... Pure Vitality Rx is Oyster Bay's premier aesthetic, anti-aging ... of services primarily dedicated to women. Services include injectables ...
(Date:7/31/2014)... Some pain relief medications can be as ... Every day, 46 people in the U.S. die from ... people are admitted to an emergency room because of opioid ... the dangers of prescription and over-the-counter painkillers and is calling ... more to make these drugs safer. , The full report, ...
Breaking Medicine News(10 mins):Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 2Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 3Health News:Body Well Therapy Invites Massage Therapists Nationwide to "Bring Your Own Insurance Clients" 2Health News:Body Well Therapy Invites Massage Therapists Nationwide to "Bring Your Own Insurance Clients" 3Health News:Community Health Center of Snohomish County Reveals the Differences Between Pediatricians and Family Practice Providers 2Health News:Natalie Sharp's Pure Vitality Rx Upgrade - Partnership With Shangri-La Spa and Website Facelift! 2Health News:Consumer Reports Warns Against the Risks of Prescription and Over-The-Counter Painkillers 2Health News:Consumer Reports Warns Against the Risks of Prescription and Over-The-Counter Painkillers 3
... , FARMINGDALE, N.Y., Sept. 2 Misonix, ... invasive ultrasonic medical device technology, which in Europe is used ... health conditions, today announced the restructuring and expansion of its ... created; one for sales and service of the Sonablate(R) 500 ...
... Fox Chase Cancer Center has received an $8 million ... the National Institutes of Health (NCRR/NIH) to expand their ... will support advanced research into the fundamental biological processes ... new treatments. The funds for the grant were made ...
... the total mortality rate from unintentional injury increased in the ... increases were seen in some subgroups analyzed by age, race, ... Hopkins Bloomberg School of Public Health,s Center for Injury Research ... and 64 years old experienced a 230 percent increase in ...
... - Researchers are developing computer models to comb through ... or insurance claims data to automatically classify them based ... to identify the most important causes of injuries so ... of injuries in society," said Mark Lehto, an associate ...
... Washington Post study, approximately 20% of U.S. soldiers returning ... are a substantial number with post-traumatic stress disorder (PTSD), ... has become unacceptable to Army commanders and the soldiers, ... University, however, doctors will now be able to forecast ...
... ... , ... -- Spend one hour with Delaine Anderson, and it,s clear she does not shrink from life,s ... in different parts of the country before that. She even lived seven years in Greece, where ...
Cached Medicine News:Health News:Misonix Restructures and Expands Sales Organization in Europe 2Health News:Misonix Restructures and Expands Sales Organization in Europe 3Health News:Misonix Restructures and Expands Sales Organization in Europe 4Health News:Fox Chase Cancer Center receives $8 million NIH grant to expand laboratory animal research facility 2Health News:Deaths from unintentional injuries increase for many groups 2Health News:New computer models aim to classify, help reduce injury accidents 2Health News:Keeping the suicidal soldier alive 2Health News:Twitter Users Can Follow in Real Time as Local Woman Receives Cyberknife Treatment for Lung Cancer 2Health News:Twitter Users Can Follow in Real Time as Local Woman Receives Cyberknife Treatment for Lung Cancer 3Health News:Twitter Users Can Follow in Real Time as Local Woman Receives Cyberknife Treatment for Lung Cancer 4
... single-use instruments on the market., Available in standard ... Surgery. , Dual action tips provide maximum ... points to reduce the chance of alternative burn ... eliminates gapping at connection and the need for ...
Disposable sheath for use with 5mm AEM Laparoscopic Instruments ....
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
Medicine Products: