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Chimerix Updates the World Health Organization and the Global Health Security Initiative on Development of CMX001 as a Broad-Spectrum Therapeutic for Smallpox
Date:11/6/2009

RESEARCH TRIANGLE PARK, N.C., Nov. 6 /PRNewswire/ -- Chimerix, Inc., a biopharmaceutical company advancing orally-available antiviral therapeutics to address life-threatening diseases, presented updates on the development of the company's lead antiviral compound, CMX001, to the World Health Organization (WHO) and the Global Health Security Initiative (GHSI). CMX001 is a broad-spectrum antiviral agent being developed for the treatment of smallpox, as well as other serious viral infections.

Randall Lanier, Ph.D., Director of Virology for Chimerix, spoke at the WHO 11th meeting of the Advisory Committee on Variola Virus Research in Geneva, Switzerland, on Wednesday, November 4, 2009. George Painter, Ph.D., Chimerix's Chief Executive Officer, spoke to the GHSI's Public Health Emergency Medical Countermeasures Workshop on Thursday, November 5, 2009. Dr. Painter's and Dr. Lanier's presentations included updates on the development of CMX001 for both biodefense and commercial uses as a broad-spectrum antiviral against double-stranded DNA viruses, including variola, as well as recent uses of the product under Emergency Investigational New Drug (E-IND) protocols against adenovirus and progressive vaccinia in immune-compromised patients.

Dr. Painter said, with regard to both the WHO and GHSI presentations, "We are quite pleased with the progress of CMX001 and look forward to working with both the U.S. and international public health and transplant communities to continue to move the product toward regulatory approval."

CMX001 combines Chimerix's PIM (phospholipid intramembrane microfluidization) Conjugate Technology with cidofovir, an approved antiviral agent, with the aim of creating a well-tolerated and highly potent new chemical entity with broad-spectrum antiviral activity. CMX001 is initially being developed for both commercial and medical preparedness uses. Chimerix is currently conducting clinical trials of CMX001 for the
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