Navigation Links
Chimerix Signs Worldwide License Agreement With Merck For CMX157, A Novel Candidate For The Treatment Of HIV
Date:7/24/2012

vir against all major HIV subtypes resistant to current therapies, which may allow activity against tenofovir-resistant viruses (e.g., K65R), and against HBV.  CMX157's novel structure results in decreased circulating levels of tenofovir, lowering systemic exposure and thereby reducing the potential for renal side effects.  CMX157 has completed a Phase 1 clinical trial in healthy volunteers, demonstrating a favorable safety, tolerability and drug distribution profile. 

About Chimerix
Led by an experienced antiviral drug development team, Chimerix is developing novel oral antiviral therapeutics with the potential to improve quality of life for patients in multiple settings, including transplant, oncology, acute care and global health.  The company's proprietary lipid technology has given rise to two clinical stage compounds, CMX001 and CMX157, which have demonstrated the potential for enhanced activity, bioavailability and safety compared to currently approved drugs. 

Chimerix's lead compound, CMX001, is a broad spectrum lipid acyclic nucleoside phosphonate that inhibits double-stranded DNA (dsDNA) viruses including cytomegalovirus (CMV), adenovirus, BK virus, herpes simplex virus and variola (smallpox).  CMX001 has completed Phase 2 clinical development for the prophylaxis of CMV and is in Phase 2 development for the preemption and treatment of adenovirus infection in hematopoietic stem cell transplant (HSCT) recipients.  To date, more than 750 patients have been dosed with CMX001 in controlled clinical trials and open-label treatment protocols.  Antiviral activity from completed and ongoing studies, coupled with the lack of myelotoxicity and nephrotoxicity that are associated with currently available therapies, indicate that CMX001 has the potential to improve outcomes for stem cell and solid organ transplant recipients.  Chimerix has completed an End of Phase 2 meeting with the FDA for CMX001 and is
'/>"/>

SOURCE Chimerix, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Chimerix Announces BK Virus Data In Late-Breaking Poster Session At The 24th International Congress Of The Transplantation Society
2. Chimerixs Broad Spectrum Antiviral Therapeutic, CMX001, Demonstrates Potential To Mitigate BK Virus Associated End-Organ Disease In Clinical Study
3. AtheroNova Signs Agreement for Development of Clinical Trial Supplies
4. Southern Research Signs Agreement with Apath, LLC to Conduct Preclinical Studies with Virus-Based HCV Screenings
5. VWR International, LLC Signs Agreement to Acquire basan Germany GmbH
6. Haemonetics Signs Definitive Agreement To Acquire Hemerus Medical, LLC
7. Haemonetics Signs Definitive Agreement to Acquire Pall Corporations Blood Collection, Filtration and Processing Product Lines For $551 Million
8. H. D. Smith Signs Three Year Prime Vendor Agreement with PharmacyGPO Buying Group
9. Bacterin International Signs Its Third National GPO Contract with Novation
10. MusclePharm Signs Pro Baseball Rookie Phenom Bryce Harper As Sponsored Athlete
11. Masimo Signs Pronto-7™ Distribution Deal with Henry Schein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... , May 21, 2015  Cardica, Inc. (Nasdaq: ... employee Greg Watson , the company,s vice president of ... the company,s common stock, at a per share exercise price ... The stock option was granted pursuant to Cardica, Inc.,s Inducement ... in May 2015 under Rule 5653(c)(4) of the Nasdaq Global ...
(Date:5/21/2015)... , May 21, 2015 The ... statement regarding the Medicare Part D offsets included ... Cures initiative: "If the 21st Century Cures ... from America,s premier health program – Medicare – ... may yield down the road. "Leveraging ...
(Date:5/21/2015)... 21, 2015 ... Zwecks Leistungsvergleich zur Expertise und zum ... verwiesen, in denen uneingeschränkt betriebsfähige Systeme, ... ein Aegate-Land: beispielsweise BELGIEN   ... von Arzneimittelfälschungen (FMD) handelt es sich ...
Breaking Medicine Technology:Cardica Announces New Employment Inducement Grant 2EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 2EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 3
(Date:5/24/2015)... NC (PRWEB) May 24, 2015 Scientists ... a paper on air quality compliance issues that may ... American workers. Surviving Mesothelioma has just posted an article ... now. , The group found airborne asbestos levels ... data collected between 1984 and 2011. , “Asbestos compliance ...
(Date:5/24/2015)... May 24, 2015 Medicx Media ... Media strategy executive Jay Krihak as its head ... to ramp up its expertise and leadership position ... Pharmaceutical and Health sectors. , Krihak is an ... Most recently, Krihak led sales planning teams for ...
(Date:5/23/2015)... Dr. David Benvenuti, an experienced plastic surgeon ... new article to his website that takes an ... explained in the fascinating blog, he has recently had ... , Known as “gauging,” the technique involves placing larger and ... said will eventually stretch the holes out to incredible sizes. ...
(Date:5/23/2015)... Chicago, IL (PRWEB) May 23, 2015 A ... of medical equipment from hospitals, surgery centers and other medical ... will be sold including endoscopy, lab, radiology, surgery, anesthesia, exam ... place Wednesday, May 27 and Thursday, May 28 starting at ... warehouse located at 1400 N. 25th Avenue, Melrose Park, IL ...
(Date:5/22/2015)... OR (PRWEB) May 22, 2015 Pioneer ... remains at the forefront of designing with reclaimed wood, ... Design in Los Angeles, California. Their newest offerings, Vat ... bring much-anticipated surface and color to America's largest design ... our exhibit at each show, anxious to see and ...
Breaking Medicine News(10 mins):Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2Health News:Over 5,200 Lots of Medical Equipment Will Be Sold by Live Auction 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3
... Partnership Develops First-Ever Toolkits to Address ,The ... in America Today, SACRAMENTO, Calif., March 26 ... activities, the California Association of,Health Plans (CAHP) and ... up to encourage physicians to discuss healthier,lifestyles with ...
... up healthier than those rejected, study says , , WEDNESDAY, ... a child,s problems forming relationships and being accepted by ... depression than vice versa, particularly during the transition from ... researchers at the universities of Vermont and Minnesota, found ...
... the earliest days of brain development, the brains first cells ... of cells that eventually evolves into the various cells of ... that, in mice, is critical for these stem cells to ... , The finding offers insight into the first steps ...
... Emageon Inc.,(Nasdaq: EMAG ), a leader ... and healthcare networks, announced today that its,HeartSuite(TM) ... award for,Cardiology PACS*. HeartSuite is Emageon,s comprehensive ... cardiovascular information,management, hemodynamic monitoring, advanced visualization and ...
... The,Children,s Hospital of Philadelphia (CHOP) support the comprehensive,evidence-based ... Driver,Study Commission. If adopted into policy, these recommendations ... teens: motor vehicle crash injury., "The commission,s ... research in the field of teen driving," said ...
... March 26 Toxikon Corporation will host,their ... April 17 at their,headquarters in Bedford, Massachusetts., ... As safety-testing guidelines continue to be updated ... testing requirements,appropriate for their product. With new ...
Cached Medicine News:Health News:California Association of Health Plans & California Medical Association Foundation Team Up to Combat Obesity 2Health News:California Association of Health Plans & California Medical Association Foundation Team Up to Combat Obesity 3Health News:California Association of Health Plans & California Medical Association Foundation Team Up to Combat Obesity 4Health News:Social Problems in Youth Contribute to Anxiety, Depression 2Health News:Key factor in brain development revealed, offers insight into disorder 2Health News:Key factor in brain development revealed, offers insight into disorder 3Health News:Emageon Receives 'Best in KLAS' Cardiology PACS Award 2Health News:Teen Driving Experts at The Children's Hospital of Philadelphia Support New Recommendations From the New Jersey Teen Driver Study Commission 2Health News:Teen Driving Experts at The Children's Hospital of Philadelphia Support New Recommendations From the New Jersey Teen Driver Study Commission 3
6 mm wide tip. Gentle tapered blade. Designated most popular model or size....
4 mm wide tip. Designated most popular model or size....
Double-ended. 3 mm x 5 mm curette end and 3 mm spatula end....
Double-ended. 6 mm x 9 mm and 6 mm x 11 mm tips....
Medicine Products: