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Chimerix Reaffirms Its Commitment to CMX001 as a Medical Countermeasure for Smallpox and Broad-Spectrum Antiviral Agent
Date:11/7/2010

eclinical studies.  Administration of a single dose of CMX001 in relevant animal models of lethal smallpox infections after the development of lesions has shown evidence of preventing death.  Smallpox is a double-stranded DNA (dsDNA) virus, as are herpesviruses, papillomaviruses, and polyomaviruses that commonly infect humans.

Beyond its potential use as a medical countermeasure, CMX001 is in Phase 2 human clinical studies in immunocompromised transplant and cancer patients for the treatment of life-threatening viruses.  Over 300 people have received CMX001 to date.  In Chimerix's ongoing placebo-controlled clinical trial programs to evaluate the compound's safety and efficacy, CMX001 has been administered to more than 200 people, including healthy volunteers and patients.  In addition, CMX001 has been administered to more than 100 patients under investigator-held Emergency Investigational New Drug applications (EINDs) for the treatment of a wide range of life-threatening infections caused by dsDNA viruses for which there are either no approved treatments or where patients have failed the available treatment.  To date, CMX001 has been used to treat patients with dsDNA viral infections caused by cytomegalovirus, vaccinia virus, herpesviruses (including herpes simplex virus, Epstein-Barr virus and HHV-6,) human papillomaviruses, JC and BK polyomavirus, and adenovirus.  Demonstration of activity and safety in human disease is likely to play an important role in the evaluation of drug activity and safety for the treatment of smallpox.  

CMX001 may be uniquely effective in the treatment of and protection against smallpox among the estimated 80-90 million Americans whose immune systems are compromised, such as those under treatment for cancer and many chronic diseases or people living with HIV.  

"We believe that it is critically important to show antiviral activity in immunocompromised populations, as they
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SOURCE Chimerix, Inc.
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