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Chimerix Presents Data Highlighting Burden Of Care Associated With Current Antiviral Therapies In Stem Cell Transplantation
Date:9/21/2012

hile the currently available antiviral agents are associated with significant adverse events, including cytopenias, nephrotoxicity, electrolyte imbalances, and others, it cannot be determined from this retrospective analysis the degree to which a specific antiviral may have contributed to the occurrence or severity of any particular AE.

Unmet Medical and Economic Needs
It is widely accepted that viral infections, including CMV, adenovirus (AdV) and BK virus (BKV) infections, cause significant morbidity and mortality in HSCT recipients.  These data shed light on the unmet medical needs associated with the current standard of care, preemptive therapy, and on the limitations of currently available antiviral agents.

In addition to the impact on morbidity and mortality, preemptive therapy dramatically increases the already significant costs associated with transplantation.  The need for intervention and management of AEs, including hospitalization and the employment of expensive antivirals, antibiotics, antifungals and colony stimulating factors, place additional strains on an already over-burdened health care system.

Data from CMX001 Study 201
The data was presented by Herve Mommeja-Marin, M.D., Vice President of Clinical Research at Chimerix.  According to Dr. Mommeja-Marin,

"There is a clear and unmet medical need for new antiviral compounds with improved safety, efficacy, and health economic profiles.  An ideal antiviral will be sufficiently safe and effective to allow for the prophylactic administration of the drug to all at-risk patients, preventing infection from occurring and avoiding the morbidity, mortality, and costs associated with preemptive therapy." 

In an effort to meet these significant medical and economic needs, Chimerix is developing CMX001, a novel broad-spectrum antiviral with activity against double-stranded DNA (dsDNA) viruses. These viruses
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SOURCE Chimerix, Inc.
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