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Chimerix Commences CMX001 Open-Label Clinical Study for the Treatment of Patients With Life-Threatening or Serious dsDNA Viral Infections
Date:1/7/2011

Emergency Investigational New Drug applications (EINDs).  At the request of leading physicians, Chimerix has to date provided CMX001 to more than 130 patients under EINDs or foreign equivalent at over 45 medical centers in the United States, Canada, Europe and Israel. CMX001 has been used for the treatment of life-threatening dsDNA infections where either there are no FDA-approved treatments or the patients have failed the available treatments.  Patients treated with CMX001 have had infections from all five classes of dsDNA viruses that infect humans, including AdV, herpes viruses such as CMV, HSV and Epstein Barr virus, polyoma viruses such as BK virus and JC virus, and pox viruses.  Data from these EIND experiences have been recently reported in a number of publications and medical conferences, and are available on the Chimerix website at www.chimerix.com.

Additional information on study objectives, enrollment criteria and patient eligibility for the CMX001-350 study is available at www.clinicaltrials.gov.

About Chimerix

Chimerix is developing novel antiviral therapeutics with the potential to transform patient care in multiple settings, including transplant, oncology, acute care and global health.  

The company's lead candidate, CMX001, is being developed as a potential broad-spectrum antiviral agent for the treatment of life-threatening dsDNA viral diseases.  Clinical studies of CMX001 include an ongoing Phase 2 study of the prevention/control of cytomegalovirus (CMV) in hematopoietic stem cell transplant patients (CMX001-201), a Phase 2 study being initiated for the treatment of adenovirus (AdV) infection in pediatric and adult hematopoietic stem cell transplant patients (CMX001-202), and an Open-Label Study (CMX001-305) for the treatment of any of 12 different dsDNA viral infections, including AdV, herpes viruses such
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