Navigation Links
Chimerix Commences CMX001 Open-Label Clinical Study for the Treatment of Patients With Life-Threatening or Serious dsDNA Viral Infections
Date:1/7/2011

s, including the more than 130 Emergency INDs requested by leading investigators," said Wendy Painter, M.D., M.P.H., Chief Medical Officer of Chimerix.  "The demand for CMX001 to treat life-threatening infections continues to grow among the clinical community, and we are extremely proud to provide CMX001 under this open-label study."

CMX001-350 Open-Label Study Design

The primary objective of the multicenter open-label study of CMX001 is to provide CMX001 to patients with immediately life-threatening or serious disease caused by any of 12 different viral infections resulting from dsDNA viruses. The open-label study is expected to enroll 200 infected adult and pediatric patients.  Critically-ill patients expected to enroll in this study in the highest numbers include immunocompromised patients suffering from a variety of dsDNA infections, particularly patients undergoing solid organ transplant or hematopoietic stem cell transplant.  However, the study is intended for any patient with a serious dsDNA viral disease for whom no satisfactory alternate therapy is available and who does not qualify for other CMX001 clinical studies.(1)

The study will evaluate the safety, tolerability and antiviral activity of CMX001.  Researchers will also evaluate the activity of CMX001 through changes in clinical signs and symptoms of infection.  Patients will receive CMX001 orally twice weekly for up to three months, and treatment may be extended for up to six months depending on the patient's clinical response.  Antiviral activity will be measured by changes in viral burden from baseline in an individual patient's condition and across all patients with a given dsDNA virus.  Drug pharmacokinetics and any potential signs of drug resistance will also be assessed.

The clinical design parameters of the CMX001-350 study were based in large part on Chimerix's experiences providing CMX001 to patients under investigator-held
'/>"/>

SOURCE Chimerix, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Chimerix Initiates a Multi-dose Clinical Trial of the Companys Lead Compound, CMX001, for the Treatment for Smallpox Infection
2. Chimerix Updates the World Health Organization and the Global Health Security Initiative on Development of CMX001 as a Broad-Spectrum Therapeutic for Smallpox
3. Chimerix to Present at Two Upcoming Investor Conferences
4. Chimerix CEO George Painter, Ph.D., to Speak on Improving Biodefense Product Discovery and Development Strategies at Institute of Medicine Workshop
5. Chimerix Initiates Phase 2 Study of CMX001 in Stem Cell Transplant Recipients Seropositive for Cytomegalovirus
6. Chimerix Appoints Thomas Pitler, Ph.D., Vice President, Business Development
7. Chimerix to Present at 9th Annual BIO Investor Forum
8. Chimerix Reaffirms Its Commitment to CMX001 as a Medical Countermeasure for Smallpox and Broad-Spectrum Antiviral Agent
9. Chimerix to Present at the Lazard Capital Markets 7th Annual Healthcare Conference
10. Chimerixs Antiviral CMX157 Demonstrates Positive Phase 1 Clinical Results With Favorable Pharmacokinetics, Safety and Tolerability
11. Memory Pharmaceuticals Commences Phase 1 Clinical Program for R4996/MEM 63908
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 23, 2014 Sinovac Biotech Ltd. (NASDAQ: ... China , announced today that it has been ... ("Beijing CDC") to be a supplier of the seasonal influenza ... for 2014. The Beijing CDC plans to order ... vaccine this year from four domestic vaccine manufacturers for its ...
(Date:7/23/2014)... , Indien, July 23, 2014 /PRNewswire/ ... additional scope für Arbeiten für Sadara Chemical ... comprehensive Engineering Information System innerhalb des integrierten ... Dieser award of additional scope im Wert ... des zuvor abgeschlossenen Vertrags dar, dessen Wert ...
(Date:7/22/2014)... -- Nektar Therapeutics (Nasdaq: NKTR ) will announce its ... on Thursday, July 31, 2014, after the close of U.S.-based ... officer, will host a conference call to review the results ... (PT). The press release and a live ... a link that is posted on the home page and ...
Breaking Medicine Technology:Sinovac Receives Beijing CDC Tender to Supply Seasonal Flu Vaccine Anflu 2Rolta gewinnt Follow-on Award für Engineering Systems für Sadara, Saudi-Arabien im Wert von mehreren Millionen Dollar 2Rolta gewinnt Follow-on Award für Engineering Systems für Sadara, Saudi-Arabien im Wert von mehreren Millionen Dollar 3Rolta gewinnt Follow-on Award für Engineering Systems für Sadara, Saudi-Arabien im Wert von mehreren Millionen Dollar 4Nektar to Announce Financial Results for the Second Quarter 2014 on Thursday, July 31, 2014, After Close of U.S.-Based Financial Markets 2Nektar to Announce Financial Results for the Second Quarter 2014 on Thursday, July 31, 2014, After Close of U.S.-Based Financial Markets 3
... speech today to the City Club of San Diego, John ... Lilly and Company (NYSE: LLY ), said that the ... vision for biopharmaceutical companies to "reinvent innovation" to make the ... and address unmet medical needs. Lechleiter,s remarks came the ...
... 30 Physicians at St. David,s South Austin Hospital ... Lead-extraction is a complicated procedure to remove leads, or ... or other implanted Cardiac Rhythm Management (CRM) devices. Recent ... a safe and effective way to remove cardiac leads ...
Cached Medicine Technology:Lilly CEO Lechleiter Calls for Repair of the 'Engine of Biopharma Innovation' 2Lilly CEO Lechleiter Calls for Repair of the 'Engine of Biopharma Innovation' 3St. David's South Austin Hospital Leading the Central Texas Region in Laser-Assisted Lead-Extraction Procedures 2St. David's South Austin Hospital Leading the Central Texas Region in Laser-Assisted Lead-Extraction Procedures 3
(Date:7/23/2014)... Boston, MA (PRWEB) July 23, 2014 ... professional medical education to a community of more than ... of Medicine Ultrasound Institute will launch a national continuing ... primary care clinicians about new advancements in ultrasound and ... , Pri-Med and the University of South Carolina School ...
(Date:7/23/2014)... QueenBeeTickets.com is reducing the prices of History of The Eagles ... who are still in the process of looking for concert ... use promo code “DISCOUNT” to get even lower prices than ... of discounted tickets at QueenBeeTickets.com. , The phenomenal band will ... The Eagles concert tickets literally disappearing across the country. The ...
(Date:7/23/2014)... 2014 ISI Telemanagement Solutions, Inc., a ... Infortel Speech Analytics, a new product as part ... Analytics gives users the ability to uncover vital customer ... , as well as chat sessions and social media ... be new, adding speech analytics on to a recording ...
(Date:7/23/2014)... According to the latest market reports compiled ... region, the Northern Virginia real estate market ... quickly throughout the area, and median sale prices have ... Virginia market includes the city of Alexandria, and Arlington, ... Virginia region saw median sale prices increase in some ...
(Date:7/23/2014)... Online medical service provider MeMD has appointed ... Dr. Lorenzo joins the MeMD executive team with over ... a part of this remote treatment model, telemedicine. This is ... in medical school, that someday we could treat people across ... here and it hasn't been that long,” says Dr. Lorenzo. ...
Breaking Medicine News(10 mins):Health News:Pri-Med and the University of South Carolina School of Medicine Launch National Ultrasound Education Initiative for Primary Care Clinicians 2Health News:Pri-Med and the University of South Carolina School of Medicine Launch National Ultrasound Education Initiative for Primary Care Clinicians 3Health News:History of The Eagles Tour Tickets: QueenBeeTickets.com Reduces Prices on Remaining Inventory of Concert Tickets for 2014 Shows 2Health News:ISI Telemanagement Solutions, Inc. Releases Infortel® Speech Analytics 2Health News:ISI Telemanagement Solutions, Inc. Releases Infortel® Speech Analytics 3Health News:Northern Virginia Real Estate Company Pasquali Realty Group Announces Median Sale Price Increased in the Region in June 2014 2Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 2Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 3
... Group, Inc. (Phyhealth) (Pink Sheets: PHYH), a developer of,health ... its board of directors has approved a stock buyback,program ... Common Stock., The shares will be purchased on ... be made at the Company,s discretion and can begin ...
... NEW YORK, Oct. 30 The American Fertility ... educational program,which brings young women together in a ... "dos and don,ts" of preserving fertility. It,s,free, relaxing, ... 20 U.S.,cities and be hosted by leading professionals ...
... Trane CleanEffects(TM) Reduces Dust by Half While Helping to ... Prevent Allergy Symptoms and Asthma Attacks, TYLER, ... Engineering Inc. (EH&E) and professors at the,Harvard School of Public ... reduces dust accumulation in,the home by more than 50 percent ...
... change when clocks are adjusted , , WEDNESDAY, Oct. 29 (HealthDay ... about here, and it may pose problems more serious than ... in the number of heart attacks following the semi-annual one-hour ... "This was the very first study on this topic and ...
... 30 Cardo Medical, a company engaged,in the ... 510k,clearance of its Align 360 Total Knee System. ... commercial release during the second quarter of 2009.,Cardo ... product within,its Align 360 platform which has already ...
... 30 Eclipsemed, Ltd is pleased to announce,availability ... Human Med based in Germany. Body-Jet is the ... safer liposuction option., While traditional liposuction basically ... requiring impact on the fat cell itself.,Body-Jet uses ...
Cached Medicine News:Health News:Phyhealth Announces Stock Buyback Program 2Health News:Phyhealth Announces Stock Buyback Program 3Health News:The American Fertility Association Announces Plan to Help Young Women Preserve Fertility 2Health News:Studies Reveal Every Homeowner's Dream: You Can Dust Less and Have a Healthier, Cleaner Home 2Health News:Studies Reveal Every Homeowner's Dream: You Can Dust Less and Have a Healthier, Cleaner Home 3Health News:Semi-Annual Time Changes May Affect the Heart 2Health News:Semi-Annual Time Changes May Affect the Heart 3Health News:Cardo Medical Announces FDA Clearance of the Align 360 Total Knee System 2Health News:Cardo Medical Announces FDA Clearance of the Align 360 Total Knee System 3Health News:Body-Jet Water-Assisted Liposuction Establishes New Standard for Liposuction and Fat Harvesting 2
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... dials to make it easier and more ... setting of the exam room. Put away ... off throughout the entire process. The Illuminated ... cylinder axis scales that are easier than ...
... The full color LCD screen, ... joystick controls, enable any member ... quick and accurate measurements.,Measurement data ... color screen, and results can ...
... who need punctal occlusion want ... relief. They also want their ... comfortable and as unobtrusive as ... punctal plugs are growing in ...
Medicine Products: