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Chimerix Announces Presentation of Final Data from CMX001 Phase 2 Trial in Prophylaxis of Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients
Date:1/25/2012

RESEARCH TRIANGLE PARK, N.C., Jan. 25, 2012 /PRNewswire/ -- Chimerix, Inc., a biotechnology company developing novel antiviral therapeutics, today announced that final data from CMX001 Study 201, a Phase 2 study evaluating CMX001 for the prevention of cytomegalovirus (CMV), has been accepted for oral presentation at the BMT Tandem Meetings on February 1-5, 2012, in San Diego, California.  CMX001 is a broad spectrum, Lipid-Antiviral-Conjugate completing Phase 2 clinical development for the prevention of CMV in hematopoietic cell transplant (HCT) recipients.  In total, three abstracts related to CMX001 have been accepted for presentation at the 2012 BMT Tandem Meetings, the combined annual meetings of the Center for International Blood and Marrow Transplant Research (CIBMTR) and the American Society of Blood and Marrow Transplantation (ASBMT).

Francisco Marty, MD, Assistant Professor of Medicine at Brigham and Women's Hospital's Division of Infectious Disease and a lead investigator in Chimerix's CMX001 Phase 2 CMV study, will present the data during the "Best Abstracts Plenary Session" at 4:45 pm on Friday, February 3 in the Elizabeth Ballroom at the Manchester Grand Hyatt in San Diego.  The presentation, entitled "CMX001 for Prevention and Control of CMV Infection in CMV-Seropositive Allogeneic Stem Cell Transplant Recipients: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Trial of Safety, Tolerability and Antiviral Activity," will highlight safety and efficacy results from the Phase 2 trial in 230 hematopoietic cell transplant recipients.  

"Existing therapies for the prophylaxis and treatment of viral infections, including CMV, in the transplant recipient population are limited by their lack of broad spectrum efficacy and major side effects, notably nephrotoxicity and myelosuppression," said Wendy P. Painter, MD, MPH, Chimerix's Chief Medical Officer.  "The prevalence of the disease and the limita
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