Navigation Links
Children's Hospital Receives Six-Year Federal Contract to Study Antibiotic Use in Children With Urinary Tract Infections

--Will Shorter Treatments Reduce Drug Resistance?--

PHILADELPHIA, Sept. 10 /PRNewswire-USNewswire/ -- In the largest study of its kind, pediatric researchers at The Children's Hospital of Philadelphia have received a federal contract for a project to determine the most beneficial method of using antibiotics to treat urinary tract infections (UTIs) in children.

The award, announced September 2 by the National Institute of Allergy and Infectious Diseases (NIAID), aims to answer key questions about the best use of antimicrobial drugs against UTIs, the most common disorder of the kidneys and urinary tract in early childhood. UTIs are highly treatable, but an infection that goes untreated may lead to serious kidney damage.

Because widespread antibiotic use has allowed bacteria to evolve strains that are resistant to common drugs, the new study will investigate whether using antibiotics over a shorter period than the standard 10 days is an effective treatment, while reducing the risk of drug resistance.

The initial award is for $1.5 million, with total funding of $13.8 million available over the project's six-year duration if clinical trial milestones are met. Theoklis Zaoutis, M.D., M.S.C.E., an infectious diseases specialist at the Center for Pediatric Clinical Effectiveness at The Children's Hospital of Philadelphia, is the principal investigator of the NIAID study. The clinical trial will enroll 700 children at two centers -- the Children's Hospital of Philadelphia and the Children's Hospital of Pittsburgh.

It will be the largest clinical trial to compare a short course versus the standard course of antimicrobial treatments for UTIs in children, said Zaoutis.

"Our goals will be to determine the optimal duration of antimicrobial treatment for UTIs," added Zaoutis. "This information will allow doctors to improve pediatric care while reducing unnecessary use of these drugs." After an initial period to prepare the trial, Zaoutis expects to begin enrolling children in 2010.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit

    CONTACT: John Ascenzi
    Phone: (267) 426-6055

SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. MedImmunes Motavizumab Reduced RSV Hospitalizations by 83 Percent Among High-Risk Native American, Full-Term Infants in Placebo-Controlled Phase 3 study
2. Gilbert Hospital Continues Cutting Edge Treatments
3. Siemens Preclinical Imaging System Helps The Methodist Hospital in Houston Further Its Research Mission
4. New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias
5. AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study
6. INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients
7. Cardinal Health Releases New Tool to Combat MRSA Infections in Hospitals
8. Hospital to Hold MRSA Briefing for Media and Community Leaders
9. Arizona Heart Hospital Reaches Settlement Regarding Clinical Research Matter
10. Providence Hospital Study Finds Communication System Leads to Faster Heart Attack Treatment
11. Allegheny General Hospital Performs First Liver Transplant
Post Your Comments:
(Date:11/29/2015)... , Nov. 29, 2015   Royal Philips  ... driven radiology solutions at the 2015 Radiological Society of ... 4 at McCormick Place in Chicago ... will experience the company,s broad portfolio of integrated Diagnostic ... solutions to increase clinical performance, improve workflow and create ...
(Date:11/29/2015)... 29, 2015   National Decision Support Company (NDSC) ... base, including notable statewide implementations. As a result, ... ACR Select, more than 1 million times per ... ACR Select provides real-time feedback on the most ... has been implemented at over 100 healthcare systems ...
(Date:11/27/2015)... Nov. 27, 2015  Lannett Company, Inc. (NYSE: ... completed the acquisition of Kremers Urban Pharmaceuticals Inc. ... global biopharmaceuticals company UCB S.A. (Euronext: UCB). ... has acquired KU from UCB for total consideration ... including a customary working capital adjustment, a deduction ...
Breaking Medicine Technology:
(Date:11/30/2015)... Juan, Puerto Rico (PRWEB) , ... November 30, 2015 , ... ... an active part of the San Juan Beauty Show held on November 8th and ... event was attended by media personalities, hair artists, renowned beauticians and top of the ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... their strategic partnership at the Radiological Society of North America (RSNA) 2015 ... global providers of cutting-edge dictation and speech-enabled documentation software, announced their partnership ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... announces the Unstoppable Swappables, a household invention that provides an economical and easy ... a year and is growing at 2.6%," says Scott Cooper, CEO and Creative ...
(Date:11/29/2015)... Clarkston, Metamora, Michigan (PRWEB) , ... ... ... Excellence is once again accredited by the American Institute of Ultrasound in ... that allows practices to demonstrate that they meet or exceed nationally recognized ...
(Date:11/29/2015)... ... 2015 , ... Khanna Vision Institute based in Los Angeles, announced that Dr. ... 2015. Peer Certification by the Board is done so the public knows that the ... obtained after the completion of three years of training or Residency in Ophthalmology. This ...
Breaking Medicine News(10 mins):