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Children's Brain Tumor Foundation's Tissue Bank Consortium May Solve Dire Problem in Pediatric Cancer Research
Date:7/1/2008

ons. Through the multi-institution research program, participating hospitals will agree to collect and analyze tissue samples and share data publicly. A standardized database will be used to collect and centrally record clinical data. Children's Hospital of Philadelphia, Children's Hospital of Pittsburgh and Children's Memorial Hospital in Chicago are participating in the planning study, which will be led by Tom Curran, PhD, Deputy Scientific Director, and Children's Hospital of Philadelphia.

According to Dr. Curran, although pediatric brain tumors can be devastating, their low incidence has created a roadblock for researchers who need a large enough data set to conduct statistically significant analyses. "Everyone in this field believes that research is the key to better treatments, but this is very much a numbers game," explained Dr. Curran. "We need the power of statistics with a large sample set to make a difference."

The consortium will provide the foundation for building that volume. In the project's initial phase, Dr. Curran is planning the procedures to establish consistent tissue collection and analysis from participating hospitals. The second phase will establish the network to collect and analyze the samples, creating a significant volume of uniformly processed tumor material. "Once we have this avenue for collecting and characterizing a large enough sample set, then we can apply very sophisticated genomic research tools to understanding the origin and genetic mutations responsible for pediatric brain tumors, with the hope of uncovering new therapeutic avenues," Dr. Curran said. "Collecting and characterizing the samples is just a beginning. We also would try to collect tumor materials to promulgate in model systems that we can make them available to any investigator who needs them for study."

While overall cancer death rates have been dropping since the early 1990s, children's brain and spinal cord tumors are still the deadliest chil
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SOURCE Children's Brain Tumor Foundation
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