Navigation Links
ChemoCentryx Reports Positive Results and Completion of Phase I Clinical Studies of Novel CCR2 Antagonist, CCX140, at the European Association for the Study of Diabetes (EASD)
Date:9/21/2010

MOUNTAIN VIEW, Calif., Sept. 21 /PRNewswire/ -- ChemoCentryx, Inc., today announced that it reported positive preclinical and Phase I study results at the European Association for the Study of Diabetes (EASD).  CCX140, a novel, orally bioavailable small molecule antagonist of the chemokine receptor CCR2, improved metabolic function while significantly reducing inflammatory macrophages found in adipose tissue in an animal model, and was well tolerated in Phase I clinical trials.  These data were presented today in a poster presentation entitled "CCR2 Antagonist CCX140-B in Phase 2 for Diabetes" in Stockholm, Sweden.  Data from an ongoing Phase II clinical trial in patients with type 2 diabetes mellitus is expected by the end of 2010 or early 2011.  

Results showed that daily treatment with CCX140 significantly improved fasting glucose and ameliorated insulin resistance (HOMA-IR) in obese, diabetic mice over a 28 day treatment period without a corresponding increase in MCP-1 (also called chemokine ligand 2 (CCL2)), the main ligand for CCR2.  Circulating adiponectin levels were significantly reduced in obese, diabetic mice and this was reversed when treated with CCX140.  The metabolic improvements also correlated with a significant reduction in adipose tissue inflammatory macrophage numbers. The preclinical studies were followed by Phase I clinical trials in 88 healthy human subjects.  These Phase I studies comprised single and multiple ascending dose placebo-controlled administration of CCX140 at doses ranging from 0.05 mg to 10 mg per day.  CCX140 was well tolerated in the Phase I trials with a favorable pharmacokinetic profile suitable for 5 to 10 mg once-daily oral treatment.  A Phase II clinical trial in 140 subjects with type 2 diabetes mellitus on stable doses of metformin was initiated earlier this year based on these encouraging preclinical and Phase I clinical results. The Phase II clinical trial is ongoi
'/>"/>

SOURCE ChemoCentryx, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. ChemoCentryx Initiates Clinical Trial of CCR1 Inhibitor CCX354
2. ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohns Disease
3. PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryxs Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference
4. ChemoCentryx Reports Additional New Data from the PROTECT-1 Study Demonstrating Traficet-ENs Effectiveness in Maintaining Remission in Patients with Crohns Disease
5. ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases
6. ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference
7. ChemoCentryx Initiates Phase 2 Clinical Trial of CCX354 for the Treatment of Rheumatoid Arthritis
8. ChemoCentryx Reports that Traficet-EN Maintains Remission in Crohns Disease at the Digestive Disease Week (DDW) 2010 Conference
9. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
10. Spherix Reports Second Quarter Earnings
11. Tapestry Reports Second Quarter 2007 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... , April 24, 2015 In ... establishing employee groups around the world to access ... business hours. While there are many areas to ... must examine which best practices are necessary and ... According to research by benchmarking ...
(Date:4/24/2015)... 24, 2015 Boston Scientific Corporation (NYSE: BSX ... th Annual Healthcare Conference on May 6 in ... executive vice president and chief financial officer, and Susie ... 35-minute question and answer session regarding the company with the ... live webcast of the presentation and question and answer session ...
(Date:4/24/2015)... , April 24, 2015 ... of automated, indication-specific planning tools for radiosurgery/SBRT   ... software applications aimed at enhancing the workflow for ... spine introduced in 2013 - comes full circle ... planning tools. These new Elements enable on-the-fly generation ...
Breaking Medicine Technology:Work Around the Clock: Building Effective Global Capabilities 2Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2
... June 8, 2011 Cellular Dynamics International, Inc. ... Inc ., who will distribute CDI,s iCell® Cardiomyocytes , ... cells (iPSCs), in Japan. This distribution agreement ... Dr. James Thomson and Dr. Shinya Yamanaka ...
... June 8, 2011 Reportlinker.com announces ... is available in its catalogue: ... Global Pipeline Analysis,Competitive Landscape and Market ... http://www.reportlinker.com/p0490348/Hip-Resurfacing-Implants---Global-Pipeline-AnalysisCompetitive-Landscape-and-Market-Forecasts-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic Hip ...
Cached Medicine Technology:iPS Academia Japan, Inc. to Distribute Cellular Dynamics' iCell® Products in Japan 2iPS Academia Japan, Inc. to Distribute Cellular Dynamics' iCell® Products in Japan 3Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 2Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 3Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 4Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 5Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 6Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 7Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 8Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 9Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 10Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 11Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 12Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 13
(Date:4/26/2015)... The grand celebration got off to a festive start with ... Deb then introduced Sandy Valentine, the wife of CCAR’s Executive ... his Walk for Recovery on the Appalachian Trail. ... gratitude to the volunteers via video. Board President Tom Kirk ... CCAR’s mission. Volunteer Manager Conrad Sienkiewicz read the names ...
(Date:4/25/2015)... (PRWEB) April 26, 2015 Diversified ... based integrative healthcare event. The Integrative Healthcare Symposium ... October 23-24, 2015 at the Sheraton Parkway Toronto ... Canada is one of the most anticipated events ... relevant, evidenced-based CME program. The event aims to ...
(Date:4/25/2015)... Washington, D.C. (PRWEB) April 25, 2015 ... for Bangladesh Worker Safety issues the following statement following ... 7.8 earthquake hit Kathmandu, Nepal, resulting in the deaths ... this massive earthquake were felt across Nepal, Bangladesh, India ... to offer my heartfelt condolences to the people of ...
(Date:4/25/2015)... 2015 Carinsurancequotesinfo.com has released a new ... cost auto insurance for flatbed trucks. , ... sometimes other vehicles. They are mainly used for commercial ... released blog post explains that by comparing multiple offers, ... and other commercial vehicles. , It is now possible ...
(Date:4/25/2015)... Caicos Islands, BWI (PRWEB) April 25, 2015 ... (PLS) has celebrated three months of successfully welcoming visitors ... January 5, 2015. , As part of a ... of Providenciales airport was completely redesigned to speed up ... up the process of getting out of the airport ...
Breaking Medicine News(10 mins):Health News:The Connecticut Community for Addiction Recovery (CCAR) honors its volunteers during National Volunteer Recognition Week. 2Health News:Integrative Healthcare Event launching in Canada 2Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2
... Americans will probably have to depend on current anthrax ... year Second-generation vaccines are in the works but not ... ready to go, approved by the FDA.// ,The ... the anthrax vaccine to resume shipping after four years ...
... researchers a protein found in human fat cells may ... type-2 or adult onset diabetes. According to Dr. Lucino ... Medicine in New York , there are molecules produced ... the body and affecting the functions of different organs. ...
... the postmenopausal women enrolled in a national study had undetected ... found that these women are at increased risk of having ... Siris, of Cleavland University College of Surgeons in New Jersy, ... lose a good deal of bone density faster than it ...
... sees the heart as a pump, plain and simple, ... A. Taber, professor of biomedical engineering at Washington University ... and deformations of the heart since the mid-1980s. A ... biomechanical forces may be as important as genetics in ...
... can help older people avert a form of arthritis ... and walking an impossible one.Those who regularly walked or ... to perform activities of daily living. ,According to ... report is the first to demonstrate that exercise can ...
... disease Systemic Lupus Erythematosis has been solved by the ... the University of California, San Diego School of Medicine ... report in a nationa journal say that a gene ... symptoms remarkably similar to human SLE.// ,SLE is ...
Cached Medicine News:Health News:Fat Cell Protein Hits Type-2 Diabetes 2Health News:Low bone mass in Postmenopausal Women 2Health News:Mechanical forces drive early heart development 2Health News:Arthritis risk reduced by exercise 2Health News:Identification of gene 2
Premium Tennis Elbow Support is 2" wide with loop-lock contact closure and is foam-lined for comfort....
... The new "Innovation Joint Technology" elbow ... of medical specialists to help re-establish pain ... Elbow/Forearm Brace has been engineered to provide ... and dynamic rotation forces. Treatment use includes ...
... The new "Innovation Joint Technology" elbow ... of medical specialists to help re-establish pain ... elbow brace is engineered to provide adjustable ... motion limiting and locking mechanisms provide physicians ...
Designed to provide comfortable immobilization of the elbow...
Medicine Products: