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ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohn's Disease
Date:6/12/2008

t candidates through clinical proof-of-concept, at which point GSK will have options to license certain product candidates.

"We're delighted with the progress our team has made in advancing one of our second-generation CCR9 antagonist compounds towards the clinic," said Thomas J. Schall, Ph.D., President and Chief Executive Officer of ChemoCentryx. "This new compound adds to our existing clinical pipeline that already contains three other novel drug candidates, each targeting different chemokine receptors and currently in clinical trials. This growing clinical pipeline, in addition to our robust preclinical and discovery programs, clearly positions ChemoCentryx as an industry leader in chemokine-based therapeutics."

About CCX282-B (Traficet-EN(TM))

Traficet-EN is a small molecule, orally-available drug that is administered in capsule form and which controls the inappropriate immune system response underlying inflammatory bowel disease (IBD) by blocking the CCR9 chemokine receptor. In adults, CCR9 is a highly specific receptor expressed by T cells that migrate selectively to the digestive tract. The trafficking of T cells to the small and large intestine causes persistent inflammation that may result in Crohn's disease or ulcerative colitis - the two principal forms of IBD. In preclinical studies, the compound worked both therapeutically and prophylactically in models of Crohn's disease and ulcerative colitis. In addition to the ongoing PROTECT-1 clinical trial in Crohn's disease and the ongoing Phase II trial in celiac disease, ChemoCentryx has completed five Phase I clinical trials and one four-week Phase II Crohn's disease trial of Traficet-EN, demonstrating that the product candidate is well-tolerated and appropriate for once- or twice-daily oral dosing. Traficet-EN may offer advantages over existing therapeutic approaches for Crohn's disease by potentially offering reduced side effects and convenient oral dosing to patients.

About Cro
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SOURCE ChemoCentryx, Inc.
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