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ChemImage's Raman Chemical Imaging Used for Ingredient-Specific Particle Sizing for Inhalation Product Development
Date:3/18/2010

s such as cascade impaction and HPLC.  Raman Chemical Imaging can provide a more efficient and accurate alternative for these combination products."

This novel approach to characterization of a combination drug product enables the identification of each API via a unique Raman signature and ingredient-specific particle sizing as a result of a chemical image analysis.  This information can be especially useful during product development and formulation, providing valuable information about product quality and performance prior to entering into expensive clinical trials.

Wide-field Raman Chemical Imaging is a method that combines the capabilities of Raman spectroscopy and advanced digital imaging, detailing material morphology and composition with a high degree of specificity in a non-contact, non-destructive manner.  ChemImage provides Raman Chemical Imaging contract services for pharmaceutical customers for characterization of nasal spray suspensions, metered dose inhalers, dry powder inhaler products and many other types of drug delivery systems.  Studies can be performed on a contract basis for ingredient-specific particle size distribution, aggregation studies, polymorph identification, and stability studies as well as content uniformity and controlled release analysis.

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